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| 1 | 中国成人糖尿病、血糖与结直肠癌发病率:针对50万人的前瞻性研究显示文摘背景糖尿病可致结直肠癌(CRC)的发病风险升高。糖尿病病程和非糖尿病患者的血糖与CRC发病风险之间的相关性仍不清楚。方法2004至2008年前瞻性中国Kadoofe Biobank研究从10个不同地区纳入了512 713名受试者。在10年随访期间,在基线无癌症史的510 136名受试者中共记录有3 024例新发CRC病例(1 745例结肠癌,1 716例直肠癌)。应用Cox回归分析对糖尿病(入组前诊断或筛查发现的)或无糖尿病病史者随机血糖(RPG)水平与CRC发病相关性的校正风险比(HR)进行估计。结果基线时,共有5.8%的受试者患有糖尿病。糖尿病患者发生CRC的校正HR为1.18(95%可信区间1.04~1.33),且发生结肠癌与直肠癌的风险相当[1.19(1.01~1.39)比1.14(0.96~1135)]。这些患者发生CRC的HR随糖尿病病程的延长而下降(趋势P值为0.03)。在入组前无糖尿病的受试者中,其RPG水平与CRC发病呈正相关,基线RPG每升高1 mmol/L其发生CRC的校正HR为1.04(1.02~1.05),且发生结肠癌与直肠癌的风险亦相当[1.03(1.01~1.05)比1.04(1.02~1.06)]。在男性中,糖尿病和RPG与CRC发病风险的相关性高于女性,但其差异无统计学意义(异质性检验的P值分别为0.3和0.2)。讨论在中国成年人中,未诊断糖尿病者其糖尿病和升高的血糖水平与CRC发病风险升高相关。 | Yuanjie Pang Christiana Kartsonak yu Guo Yiping Chen Ling Yang Zheng Bian Fiona Bragg Iona Y Millwood Leijia Shen Songgen Zhou Jiben Liu Junshi Chen Liming Li Michael V Holmes Zhengming Ghen 霍永丰(译) | 2019 | 英国医学杂志中文版2019，22，1： | 6 |
| 2 | A comparison of the cytogenetic alterations and global DNA hypomethylation induced by the benzene metabolite, hy- droquinone, with those induced by melphalan and etoposide 显示文摘 | Ji Z Zhang L Pang V | 2010 | Leuke- mia2010，24，： | 1 |
| 3 | The devil and packet trace anonymization显示文摘 | ALLMAN M PAXSON V | 2006 | Computer Communication Review2006，36，1： | 1 |
| 4 | Differential AMPK phosphorylation sites associated with phenylephrine vs antihypertrophic effects of adenosine agonists in neonatal rat ventricular myocytes显示文摘 | Pang T Rajapurohitam V Cook MA | | 0，，： | 1 |
| 5 | Performance of light-frame wood residential construction subjected to earthquakes in regions of moderate seismicity显示文摘 | Ellingwood B R Rosowsky D V Pang W | 2008 | Journal of structural engineering2008，134，8： | 1 |
| 6 | Stable chloroplasts transformation in potato:use of green fluorescent protein as a plastid marker显示文摘 | Kasten D Pang S Z | 1999 | Plant J1999，19，： | 1 |
| 7 | Atlantoaxial rotatory fixation:part 3-a prospective study of the clinical manifestation,diagnosis,management,and outcome of children with alantoaxial rotatory fixation显示文摘 | Pang D Li V | 2005 | Neurosurgery2005，57，5： | 1 |
| 8 | Malformations of cortical development 显示文摘 | Pang T Atefy R Sheen V | 2008 | Neurologist2008，14，3： | 1 |
| 9 | Fast direct GPS P - Code acquisition 显示文摘 | PANG Jing FRANK V G JANUSZ S | 2003 | GPS Solutions2003，，7： | 1 |
| 10 | Is apparent diffusion coeffi- cient associated with clinical risk scores for prostate cancers that are visible on 3-T MR images显示文摘 | Turkbey B Shah V P Pang Y | 2011 | Radiology2011，258，2： | 1 |
| 11 | Evaluation of corneal epithelial healing under contact lens with spectral-domain anterior segment optical coherence tomography (SD-OCT)显示文摘 | Pang CE M V Tan DT | 2011 | Open Ophthalmol J2011，5，： | 1 |
| 12 | Effect of ban- ding or burdizzo castration on plasma testosterone, acute - phase proteins, scrotal circumference, growth, and health of bulls 显示文摘 | Pang W Y Earley B Gath V | 2008 | Livestock Science2008，117，1： | 1 |
| 13 | Effects of atlatoxin and carotenoids on growth performance and immune response in mule ducklings显示文摘 | Cheng Y H Shen T F Pang V F | 2001 | Comparative Biochem Phys C2001，128，1： | 1 |
| 14 | Hydrogeoch emistry and groundwater circulation in the Xi'an geothermal field, China显示文摘 | Qin D J Turner J V Pang Z H | 2005 | Geothermics2005，34，： | 1 |
| 15 | Stable chloroplast transformation in potato: use of green fluorescent protein as a plasmid marker显示文摘 | Sidorov V A Kasten D Pang S Z | 1999 | The Plant Journal1999，19，2： | 1 |
| 16 | Effects of aflatoxin and carotenoids on growth performance and immune response in mule ducklings 显示文摘 | CHENG Y H SHEN T F PANG V F | 2001 | Comparative Biochemistry and Physiology ( Part C) : Toxicology & Pharmacology2001，128，1： | 1 |
| 17 | Malformations of cortical development显示文摘 | Pang T Atefy R Sheen V | 2008 | Neurologist2008，14，3： | 1 |
| 18 | Malformations of cortical develop- ment 显示文摘 | Pang T Atefy R Sheen V | 2008 | Neurologist2008，14，3： | 1 |
| 19 | Atlantoaxial rotatory fixation: part 3: a pros- pective study of the clinical manifestation, diagnosis, management, and outcome of children with alantoaxial rotatory fixation 显示文摘 | Pang D Li V | 2005 | Neurosurgery2005，57，5： | 1 |
| 20 | Pseudoscleroderma secondary to phytomenadione (vitamin K1) injections: Texier's disease显示文摘 | Pang BK Munro V Kossard S | 1996 | Australas J Dermatol1996，37，1： | 1 |
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