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| 1 | Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells显示文摘瞄准:为了调查 Src, JAK2 和 phosphatidylinositol 3-kinase (PI3K ) 小径是否涉及人的结肠的瘤房间的增长,由扩大 glycine 的促胃液素导致了(G-gly ) ,先锋在 ated 促胃液素中并且到成熟阐明在响应这肽的这三家族 ases 之间的分子的相互作用。方法:用人的结肠的瘤,房间作为一个模型衬里 HCT116,我们首先测量了 PI3K, p60-Src 和 JAK2 的激活响应 G-gly 由在试管内激酶试金。然后,我们由 MTT 测试在 G-gly-induced 房间增长调查了这些家族 ases 的参与。结果:G-gly,刺激在 HCT116 导致了 p60-Src, JAK2 和 PI3K 激活。不同小径涉及房间导致了由的人的结肠癌的增长 G-gly。而且,我们发现 Src 和 JAK2 对由这肽的 PI3K 规定必要。然而,我们没发现在二酷氨酸家族 ases 之间的任何串音。结论:我们的结果建议 p60-Src/PI3K 和 JAK2/PI3K 小径独立地行动调停人的结肠的瘤房间上的 G-gly 增生的的效果。 | Audrey Ferrand Aline Kowalski-Chauvel Claudine Bertrand Daniel Fourmy Marlene Dufresne Catherine Seva Julie Pannequin | 2006 | World Journal of Gastroenterology2006，12，12： | 2 |
| 2 | The Wnt target Jagged1 mediates the activation of Notch signaling by progastrin in human colorectal cancer cells显示文摘 | Pannequin J Bonnans C Delaunay N | 2009 | Cancer Res2009，69，15： | 1 |
| 3 | Sox9 regulates cell pro?liferation and is required for Paneth cell differentiation in the in?testinal epithelium显示文摘 | Bastide P Darido C Pannequin J et a1 | 2007 | J Cell Bio!2007，，78： | 1 |
| 4 | Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium显示文摘 | Bastide P Darido C Pannequin J | 2007 | J Cell Biol2007，178，4： | 1 |
| 5 | Defective Cln-7 regulation by Tcf-4 and Sox-9 disrupts the polarity and increases the tumorigenicity of colorectal cancer cells显示文摘 | Darido C Buchert M Pannequin J | | 0，，： | 1 |
| 6 | The wnt target jag-ged-1 mediates the activation of notch signaling by progastrin inhuman colorectal cancer cells 显示文摘 | Pannequin J Bonnans C Delaunay N | 2009 | Cancer Res2009，69，15： | 1 |
| 7 | Defective claudin-7 regu-lation by Tcf-4 and Sox-9 disrupts the polarity and increases the tu-morigenicity of colorectal cancer cells显示文摘 | Darido C Buchert M Pannequin J | 2008 | Cancer Res2008，68，11： | 1 |
| 8 | Glycine-extended gastrin stimulates cell proliferation and migration through a Rho- and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway 显示文摘 | He H Pannequin J Tantiongco JP | 2005 | Am J Physiol Gastrointest Liver Physiol2005，289，3： | 1 |
| 9 | The long road to colo-rectal cancer therapy:Searching for the right signals显示文摘 | Hollande F Pannequin J Joubert D | 2010 | Drug Resist Updat2010，13，12： | 1 |
| 10 | The long road to colorectal cancer therapy:searching for the right signals显示文摘 | Hollande F Pannequin J Joubert D | 2010 | Drug Resist Updat2010，13，122： | 1 |
| 11 | β-Catenin/Tcf-4 Inhibition after Progastrin Targeting Reduces Growth and Drives Differentiation of Intestinal 显示文摘 | Pannequin J Delaunay N Buchert M | 2007 | Gastroenterology2007，133，5： | 1 |
| 12 | The Wnt target jagged-1 mediates the activation of notch signaling by progas trin in human colorectal cancer cells显示文摘 | Pannequin J Bonnans C Delaunay N | 2009 | Cancer Res2009，69，15： | 1 |
| 13 | Defective claudin-7 regula-tion by Tcf-4 and Sox-9 disrupts the polarity and increases the tu-morigenicity of colorectal cancer cells显示文摘 | Darido C Buchert M Pannequin J | 2008 | Cancer Res2008，68，11： | 1 |
| 14 | Defective Claudin-7 regulation by Tcf-4 and Sox-9 disrupts the po- larity and increases the tumorigenicity of colorectal cancer cells显示文摘 | Darido C Buchert M Pannequin J | 2008 | Cancer Res2008，68，11： | 1 |
| 15 | The wnt target jagged-1 mediates the activation of notch signaling by progastrin in hu-man colorectal cancer cells 显示文摘 | Pannequin J Bonnans C Delaunay N | 2009 | Cancer Res2009，69，60： | 1 |
| 16 | Sox 9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium显示文摘 | Bastide P Darido C Pannequin J | 2007 | J Cell Biol2007，178，4： | 1 |
| 17 | The Wnt target jagged-1 mediates the activation of notch signaling by progastrin in human colorectal cancer cells显示文摘 | Pannequin J Bonnans C Delaunay N | 2009 | Cancer Res2009，69，15： | 1 |
| 18 | How an All-or-Nothing insurance behaviour challenges economic policies:an experimental approach显示文摘Based on experimental data,this paper confirms,in a controlled environment,converging theoretical and empirical results that,when individuals insure,they choose to insure themselves with a full cover.This insurance behaviour creates an opportunity for the public authority to drive people to enter the insurance market where they would buy full insurance.This paper also sheds light on the risks of an opportunistic insurers’behaviour.This heuristic challenges the efficiency of separating contracts designed to address adverse selection issues.Indeed,a strong preference for full contracts may encourage low-risk individuals to turn to(full)contracts designed for high-risk individuals,yielding advantageous selection opportunities for insurers.However,if this heuristic strengthens the high-risks’reluctance for partial insurance,it may increase the efficiency of the separating contracts,and the lowrisk individuals suffer less from adverse selection. | Anne Corcos François Pannequin Claude Montmarquette | 2021 | Economic and Political Studies2021，9，1： | 0 |
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