|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hydroxytryptamine transporter gene-linked polymorphic region(5HTTLPR)is associated with delusions in Alzheimer’s disease显示文摘Background:Serotoninergic pathways underlying delusion symptoms in Alzheimer’s disease(AD)have not been fully clarified.5-Hydroxytryptamine transporter gene-linked polymorphic region(5-HTTLPR)is a variable number tandem repeats in the promoter region of serotonin transporter encoding-gene affecting transcription.Methods:We investigated the association of 5-HTTLPR with delusions in a total of 257 consecutive patients clinically diagnosed as AD according to the National Institute on Aging-Alzheimer’s Association criteria.All participants underwent a comprehensive evaluation with a standardized comprehensive geriatric assessment and Neuropsychiatric Inventory.Results:Delusion symptoms were observed in 171 patients(66.54%).In respect to AD patients without delusions,AD patients with delusions showed a low prevalence of S-plus carriers(5-HTTLPR-L/S+5-HTTLPR-S/S genotypes)[p<0.001;odds ratio(OR)=0.240,95% confidence interval(CI)=0.121–0.471].Logistic regression analysis adjusted for the apolipoprotein E polymorphism showed that in AD patients with delusions the presence of an 5-HTTLPR-S allele may reduce disease duration(p=0.005;OR=0.680,95% CI=0.522–0.886)and increase aberrant motor activity(p=0.013;OR=2.257,95% CI=1.195–4.260).The present findings suggested that 5-HTTLPR might be associated with delusions in AD.S-plus carriers might be associated with protective effect against delusions in AD.Conclusions:More studies on wider samples of high selected demented patients are needed to confirm our results.However,the present findings suggested that a genetic factor related to serotonin metabolism might exert a protective role on the clinical expression of neuropsychiatric clusters in AD with important implications regarding mechanisms underlying delusions and their possible treatment across the AD and dementia spectrum. | Grazia D’Onofrio Francesco Panza Daniele Sancarlo Michele Lauriola Mariangela P.Dagostino Giulia Paroni Madia Lozupone Antonio Mangiacotti Paola Bisceglia Carolina Gravina Maria Urbano Filomena Addante Francesco Paris Leandro Cascavilla Antonio Greco Davide Seripa | 2019 | Translational Neurodegeneration2019，8，1： | 2 |
| 2 | Validation of real-time three-dimensional echocardiography for quantifying left ventricular volumes in the presence of a left ventricular aneurysm: in vitro and in vivo studies显示文摘 | Jian Xin Qin Michael Jones Takahiro Shiota Neil L Greenberg Hiroyuki Tsujino Michael S Firstenberg Pankaj C Gupta Arthur D Zetts Yong Xu Jing Ping Sun Lisa A Cardon Jill A Odabashian Scott D Flamm Richard D White Julio A Panza James D Thomas | 2000 | Journal of the American College of Cardiology2000，，3： | 1 |
| 3 | Higher total cholesterol, cognitive decline, and dementia 显示文摘 | Panza F Solfrizzi V D' Introno A | 2009 | Neuro- biol Aging2009，30，4： | 1 |
| 4 | Alcohol intake in the elderly affects risk of cognitive decline and dementia显示文摘 | Panza F Frisardi V Seripa D | 2012 | Am J Alzheimers Dis Other Demen2012，27，5： | 1 |
| 5 | Lipid metabolism in cognitive decline and dementia显示文摘 | Panza F D'Introno A Colacicco AM | | 0，，： | 1 |
| 6 | Lipid metabolism in cognitive decline and dementia 显示文摘 | Panza F D'Introno A Colacicco AM | 2006 | Brain Res Rev2006，51，2： | 1 |
| 7 | Current epidemiology of mild cognitive impairment and other pre-dementia syndromes 显示文摘 | Panza F D'Introno A Colacicco AM | 2005 | Am J Geriatr Psychiatry2005，13，8： | 1 |
| 8 | Leptin increases HER2 pro- tein levels through a STAT3-mediated up-regulation of Hsp90 in breast cancer cells显示文摘 | Giordano C Vizza D Panza S | 2013 | Mol Oncol2013，7，3： | 1 |
| 9 | Lipid metabolism in cognitive decline and dementia显示文摘 | Panza F D'Introno A Colacicco AM | | 0，，： | 1 |
| 10 | Age-related hearing impairment and frailty in Alzheimer's disease: interconnected associations and mechanisms 显示文摘 | Panza F Solfrizzi V Seripa D | 2015 | Frontiers in Aging Neuroscience2015，7，： | 1 |
| 11 | Lipoproteins, vascular-related genetic factors, and human longevity 显示文摘 | Panza F D'introno A Capurso C | 2007 | Rejuvenation Res2007，10，4： | 1 |
| 12 | Diet,cholesterol metabolism,and Alzheimer′s disease:Apolipoprotein E as a possible link?显示文摘 | Panza F Capurso C D′Introno A | 2006 | J Am Geriatr Soc2006，54，12： | 1 |
| 13 | The Genetics of theHuman APOE Polymorphism显示文摘 | Seripa D DOnofrio G Panza F | 2011 | Rejuvenation Res2011，14，： | 1 |
| 14 | Heavy chain myosin 9-related disease (MYH9 -RD):neutrophil inclusions of myosin-9 as a pathognomonic sign of the disorder显示文摘 | Savoia A De Rocco D Panza E | 2010 | Thromb Haemost2010，103，4： | 1 |
| 15 | Alcohol Drinking,Cognitive Functions in Older Age,Predementia,and Dementia Syndromes显示文摘 | Panza F Capurso C D'Introno A | | 0，，01： | 1 |
| 16 | Auditory brainstem response in thyroid diseases before and after therapy显示文摘 | Lorenzo L D Foggia L Panza N | 1995 | Horm Res1995，43，5： | 1 |
| 17 | Shape Analysis of isoseismals based on empirical and synthetic data 显示文摘 | Molchan G Kronrod T Panza D | 2002 | Pure and Appl Geophys2002，159，6： | 1 |
| 18 | Shape of empirical and synthetic isoseismals: comparison for Italian M 6 earthquakes显示文摘 | Molchan G Krortrod T Panza D | 2004 | Pure and Appl Geophys2004，161，4： | 1 |
| 19 | Apolipoprotein E genotypes in hospitalized elderly patients with vascular dementia显示文摘 | Orsitto G Seripa D Panza F | 2007 | Dement Geriatr Cogn Disord2007，23，： | 1 |
| 20 | Lipoprotein (a), apolipoprotein E genotype, and risk of Alzheimer's disease 显示文摘 | Solfrizzi V Panza F D'Introno A | 2002 | J Neurol Neurosurg Psychiatry2002，72，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员