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| 1 | Implication of the Hedgehog pathway in hepatocellular carcinoma显示文摘The prognosis for patients who are diagnosed with advanced stage hepatocellular carcinoma(HCC)is poor because there are few treatment options.Recent research has focused on the identification of novel molecular entities that can be targeted to inhibit oncogenic signals that are involved in the carcinogenesis,proliferation and progression of HCC.Among all of the pathways that are involved in the development of HCC,Hedgehog(HH)signalling has demonstrated a substantial role in hepatocarcinogenesis and HCC progression.HH plays a physiological role in embryogenesis,through the induction of the differentiation of hepatocytes from endodermal progenitors.The re-activation of the HH pathway in chronic damaged liver is a mechanism of fibrotic degeneration and is implicated in various stages of HCC development.HH activation sustains the subpopulation of immature liver epithelial cells that are involved in the pathogenesis of cirrhosis and HCC,and HH itself is a mediator of the alcohol-derived malignant transformation of liver cells.High levels of expression of HH protein markers in liver tumour tissues are correlated with aggressive histological and biological features and a poor clinical outcome.In vitro and in vivo inhibition models of the HH pathway confirm that HH is essential in maintaining tumour growth,metastasis and a mesenchymal phenotype. | Carminia Maria Della Corte Giuseppe Viscardi Federica Papaccio Giovanna Esposito Giulia Martini Davide Ciardiello Erika Martinelli Fortunato Ciardiello Floriana Morgillo | 2017 | World Journal of Gastroenterology2017，23，24： | 10 |
| 2 | Dental pulp stem ceils, niches, and notch signaling in tooth injury 显示文摘 | Mitsiadis TA Feki A Papaccio G | 2011 | Adv Dent Res2011，23，3： | 1 |
| 3 | Comparison between genetic portraits of osteoblasts derived from primary cultures and osteoblasts obtained from human pulpar stern cells 显示文摘 | Carinci F Papaccio G Laino G | 2008 | Journal of Craniofacial Surgery2008，19，3： | 1 |
| 4 | Early macrophage infiltration in mice treated with low-dose streptozocin decreases islet superoxide dismutase levels:prevention by silica pretreatment显示文摘 | Papaccio G Frascatore S Esposito V | 1991 | Acta Anat (Basel)1991，142，2： | 1 |
| 5 | Early macrophage infiltration in mice treated with low-dose streptozotocin decreases islet superoxide dismutase levels:prevention by silica pretreatment显示文摘 | Papaccio G Frascatore S Esposito V | | 0，，： | 1 |
| 6 | Early macrophage infiltration in mice treated with low-dose streptozocin decreases islet superoxide dismutase levels:prevention by silica pretreat ment显示文摘 | Frascatore S Esposito V | 1991 | Acta Anat(Basel)1991，142，2： | 1 |
| 7 | Prevention of spontaneous autoimmune diabetes in NOD mice by transferring in vitro antigen-pulsed syngeneic dendritic cells显示文摘 | Papaccio G Nicoletti F Pisanti FA | 2000 | Endocrinology2000，141，4： | 1 |
| 8 | Nicotinamide decreases MHC class Ⅱ but not MHC class Ⅰ expression and increases intercellular adhesion molecule-1 structures in non-obese diabetic mouse pancreas显示文摘 | PAPACCIO G AMMENDOLA E PISANTI F A | 1999 | J Endocrinol1999，160，： | 1 |
| 9 | Comparison between genetic portraits of osteoblasts derived from primary cultures and osteoblasts obtained from human pulpar stem cells显示文摘 | Carinci F Papaccio G Laino G | | 0，，03： | 1 |
| 10 | 显示文摘 | PAPACCIO G GRAZIANO A D'AQUINO R | 2005 | Cell Physiol2005，204，1： | 1 |
| 11 | A biphasic role of nuclear transcription factor (NF) -kappaB in the islet beta-cell apoptosis induced by interleukin (IL)-1beta显示文摘 | Papaccio G Graziano A Aquino R | 2005 | J Cell Physiol2005，204，1： | 1 |
| 12 | Macrophages and antioxidant status in the NOD mouse pancreas显示文摘 | Papaccio G De LB Pisanti FA | 1998 | Cell Biochem1998，71，： | 1 |
| 13 | Nicotinamide decreases MHC class Ⅱ but not MHC class Ⅰ expression and increases intercellular adhesion molecule-1 structures in non-obese diabetic mouse pancreas显示文摘 | Papaccio G Ammendola E Pisanti FA | | 0，，03： | 1 |
| 14 | Understanding and Controlling Software Costs 显示文摘 | Boehm B W Papaccio P N | 1988 | IEEE Transaction on Software Engineering1988，14，10： | 1 |
| 15 | Distribution of the amelogenin protein in developing, injured and carious human teeth显示文摘 | Mitsiadis TA Filatova A Papaccio G | 2014 | Front Physiol2014，5，： | 1 |
| 16 | Superoxide dimutase in low-dose-streptozotin-treatedmice,a dynamic time course study显示文摘 | Papaccio G Latronico M Frascatore S | 1991 | Int J$Pancreatol1991，10，： | 1 |
| 17 | Comparison between genetic portraits of osteoblasts derived from primary cultures and osteoblasts obtained from human pulpar stem cells显示文摘 | Carinci F Papaccio G Laino G | 2008 | J Craniofac Surg2008，19，3： | 1 |
| 18 | Dental Pulp Stem Cells: A Promising Tool for Bone Regeneration显示文摘 | Riccardo d’Aquino Gianpaolo Papaccio Gregorio Laino Antonio Graziano | 2008 | Stem Cell Reviews2008，，1： | 1 |
| 19 | Dental pulp stemcells, niches, and notch signaling in tooth injury 显示文摘 | Mitsiadis TA Feki A Papaccio G | 2011 | Adv DentRes2011，23，3： | 1 |
| 20 | Early macrophage infiltration in mice treated with low dose streptozotocin decreases islet superoxide dis mutase levels: Prevention by silica pretreatment 显示文摘 | Papaccio G Fraseatore S Esposito V | 1997 | Acta Anat1997，142，2： | 1 |
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