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| 1 | Review:DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis显示文摘Tissue homeostasis requires a carefully-orchestrated balance between cell proliferation, cellular senescence and cell death. Cells proliferate through a cell cycle that is tightly regulated by cyclin-dependent kinase activities. Cellular senescence is a safeguard program limiting the proliferative competence of cells in living organisms. Apoptosis eliminates unwanted cells by the coordinated activity of gene products that regulate and effect cell death. The intimate link between the cell cycle, cellular senes- cence, apoptosis regulation, cancer development and tumor responses to cancer treatment has become eminently apparent. Extensive research on tumor suppressor genes, oncogenes, the cell cycle and apoptosis regulatory genes has revealed how the DNA damage-sensing and -signaling pathways, referred to as the DNA-damage response network, are tied to cell proliferation, cell-cycle arrest, cellular senescence and apoptosis. DNA-damage responses are complex, involving “sensor” proteins that sense the damage, and transmit signals to “transducer” proteins, which, in turn, convey the signals to numerous “effector” proteins implicated in specific cellular pathways, including DNA repair mechanisms, cell-cycle checkpoints, cellular senescence and apoptosis. The Bcl-2 family of proteins stands among the most crucial regulators of apoptosis and performs vital functions in deciding whether a cell will live or die after cancer chemotherapy and irradiation. In addition, several studies have now revealed that members of the Bcl-2 family also interface with the cell cycle, DNA repair/recombination and cellular senescence, effects that are generally distinct from their function in apoptosis. In this review, we report progress in understanding the molecular networks that regulate cell-cycle checkpoints, cellular senescence and apoptosis after DNA damage, and discuss the influence of some Bcl-2 family members on cell-cycle checkpoint regulation. | SCHMITT Estelle PAQUET Claudie BEAUCHEMIN Myriam BERTRAND Richard | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，6： | 17 |
| 2 | Differential effects of interleukin-15 (IL-15) and IL-2 on human neutrophils:modulation of phagocytosis,cytoskeleton rearrangement,gene expression,and apoptosis by IL-15显示文摘 | Girard D Paquet ME Paquin R | 1996 | Blood1996，88，8： | 2 |
| 3 | Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1显示文摘 | Dolkun Rahmutula Gregory M. Marcus Emily E. Wilson Chun-Hua Ding Yuanyuan Xiao Agnes C. Paquet Rebecca Barbeau Andrea J. Barczak David J. Erle Jeffrey E. Olgin | 2013 | Cardiovascular Research2013，，4： | 2 |
| 4 | Major outer membrane proteins of Brucella spp.: past, present and future显示文摘 | Axel Cloeckaert Nieves Vizca??no Jean-Yves Paquet Raúl A Bowden Philip H Elzer | 2002 | Veterinary Microbiology2002，，1： | 2 |
| 5 | Mass vaccination campaign with a two - dose oral cholera vaccine in a refugee camp显示文摘 | Legros D Paquet C Perea W | 1999 | Bull of WHO1999，77，10： | 1 |
| 6 | The beneficial toxicity paradox of antimicrobials in leg ulcer healing impaired by a polymicrobial flora:a proof-of-concept study显示文摘 | FUMAL I BRANHAM C PAQUET P | 2002 | Dermatology2002，204，： | 1 |
| 7 | Mutational analysis of the CYP2B2 phenobarbital response unit and inhibitory effect of the constitutive androstane receptor on phenobarbital responsiveness显示文摘 | Paquet Y Trottier E Beaudet M J | 2000 | J Biol Chem2000，275，38： | 1 |
| 8 | Major out ermembrane proteins of Brucella spp:past,present and future显示文摘 | Cloeckaert A Vizcaino N Paquet J Y | | 0，，14： | 1 |
| 9 | Cordocentesis for rapid karyo- type, 421 consecutive cases 显示文摘 | Donner C Rypens F Paquet V | 1995 | Fetal Diagn Ther1995，10，： | 1 |
| 10 | E-government & Government On-line in Canada:Partnerships,People & Prospects显示文摘 | JUILLET L PAQUET G | 2001 | Government Information Quarterly2001，18，2： | 1 |
| 11 | UNC93B1 delivers nucleotide-sensing Toll-like receptors to endolysosomes显示文摘 | Kim YM Brinkmann MM Paquet ME | 2008 | Nature2008，452，7184： | 1 |
| 12 | Gene expression profiling of the human maternal-fetal interface reveals dramatic changes between midgestation and term 显示文摘 | Winn V D Haimov K R Paquet A C | 2007 | Endocrinology2007，148，3： | 1 |
| 13 | A structural/statistical feature based vector for handwritten character recognition 显示文摘 | Heutte L Paquet T Moreau J V | 1998 | Pattern Recognition Letters1998，19，7： | 1 |
| 14 | Cell type-sepcific mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells 显示文摘 | Fan HY Liu Z Paquet M | 2009 | Cancer Res2009，69，16： | 1 |
| 15 | The value of sleep deprivation as a diagnostic tool in adult sleepwalkers 显示文摘 | Joncas S Zadra A Paquet J | 2002 | Neurology2002，58，： | 1 |
| 16 | Dominant- negative c-jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome release 显示文摘 | Whitfield J Neame S J Paquet L el al | 2001 | Neuron2001，29，3： | 1 |
| 17 | Endoscopic sclerosis and esophageal balloon tamponade in acute hemorrhage from esophagogastric varices: a prospective controlled randomized trial 显示文摘 | PAQUET KJ FEUSSNER H | 1985 | Hepatology1985，5，4： | 1 |
| 18 | Effect of the 585 nm flashlamp- pumped pulsed dye laser for the treatment of keloids显示文摘 | Paquet P Hermanns JF Pierard GE | 2001 | Dermatol Surg2001，27，2： | 1 |
| 19 | E-governance and Government On-line in Canada: Partnerships, People and Prospects显示文摘 | Allen B A Juillet L Paquet G | 2001 | Government Information Quarterly2001，18，2： | 1 |
| 20 | Kinematic Evaluation of two snow - shovel designs显示文摘 | Chia- te Huang Victor Paquet | 2002 | International Journal of Industrial Ergonomics2002，29，： | 1 |
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