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| 1 | Thymoquinone inhibits the migration of mouse neuroblastoma(Neuro-2a) cells by down-regulating MMP-2 and MMP-9显示文摘Thymoquinone(TQ), an active component derived from the medial plant Nigella sativa, has been used for medical purposes for more than 2 000 years. Recent studies have reported that TQ blocked angiogenesis in animal model and reduced migration, adhesion, and invasion of glioblastoma cells. We have recently shown that TQ could exhibit a potent cytotoxic effect and induce apoptosis in mouse neuroblastoma(Neuro-2a) cells. In the present study, TQ treatment markedly decreased the adhesion and migration of Neuro-2a cells. TQ down-regulated MMP-2 and MMP-9 protein expression and m RNA levels and their activities. Furthermore, TQ significantly down-regulated the protein expression of transcription factor NF-κB(p65) but not significantly altered the expression of N-Myc. Taken together, our data indicated that TQ's inhibitory effect on the migration of Neuro-2a cells was mediated through the suppression of MMP-2 and MMP-9 expression, suggesting that TQ treatment can be a promising therapeutic strategy for human malignant neuroblastoma. | Arumugam Paramasivam Subramanian Raghunandhakumar Jayaseelan Vijayashree Priyadharsini Gopalswamy Jayaraman | 2016 | Chinese Journal of Natural Medicines2016，14，12： | 6 |
| 2 | A Fuzzy Logic Based Supervisory Hierarchical Control Scheme for Real Time Pressure Control显示文摘This paper describes a supervisory hierarchical fuzzy controller (SHFC) for regulating pressure in a real-time pilot pressure control system. The input scaling factor tuning of a direct expert controller is made using the error and process input parameters in a closed loop system in order to obtain better controller performance for set-point change and load disturbances. This on-line tuning method reduces operator involvement and enhances the controller performance to a wide operating range. The hierarchical control scheme consists of an intelligent upper level supervisory fuzzy controller and a lower level direct fuzzy controller. The upper level controller provides a mechanism to the main goal of the system and the lower level controller delivers the solutions to a particular situation. The control algorithm for the proposed scheme has been developed and tested using an ARM7 microcontroller-based embedded target board for a nonlinear pressure process having dead time. To demonstrate the effectiveness, the results of the proposed hierarchical controller, fuzzy controller and conventional proportional-integral (PI) controller are analyzed. The results prove that the SHFC performance is better in terms of stability and robustness than the conventional control methods. | N. Kanagaraj P. Sivashanmugam S. Paramasivam | 2009 | International Journal of Automation and computing2009，6，1： | 6 |
| 3 | Novel insights into m6A modification in circular RNA and implications for immunity显示文摘Chemical modifications play an important role in modifying and regulating the functions of coding and noncoding RNAs.Noncoding RNAs mainly include microRNAs(miRNAs),long noncoding RNAs(lncRNAs),and circular RNAs(circRNAs).A common feature of these noncoding RNAs is that they are all transcribed from the genome and can perform biological functions.Importantly,the stable expression of noncoding RNAs in vivo makes them potential biomarkers for the diagnosis,prognosis,and clinical treatment of cancers and a variety of immunological diseases. | Arumugam Paramasivam Jayaseelan Vijayashree Priyadharsini | 2020 | Cellular & Molecular Immunology2020，17，6： | 5 |
| 4 | Low Pressure DC Glow Discharge Air Plasma Surface Treatment of Polyethylene (PE) Film for Improvement of Adhesive Properties显示文摘The present work deals with the change in surface properties of polyethylene (PE) film using DC low pressure glow discharge air plasma and makes it useful for technical applications. The change in hydrophilicity of the modified PE film surface was investigated by measuring contact angle and surface energy as a function of exposure time. Changes in the morphological and chemical composition of PE films were analyzed by atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS). The improvement in adhesion was studied by measuring T-peel and lap-shear strength. The results show that the wettability and surface energy of the PE film has been improved due to the introduction of oxygen-containing polar groups and an increase in surface roughness. The XPS result clearly shows the increase in concentration of oxygen content and the formation of polar groups on the polymer surface. The AFM observation on PE film shows that the roughness of the surface increased due to plasma treatment. The above morphological and chemical changes enhanced the adhesive properties of the PE film surfaces, which was confirmed by T-peel and lap-shear tests. | Krishnasamy NAVANEETHA PANDIYARAJ Vengatasamy SELVARAJAN Rajendrasing R. DESHMUKH Coimbatore. Paramasivam YOGANAND Suresh BALASUBRAMANIAN Sundaram MARUTHAMUTHU | 2013 | Plasma Science and Technology2013，15，1： | 2 |
| 5 | Ceric ammonium nitrate supported HY-zeolite:An efficient catalyst for the synthesis of 1,8-dioxo-octahydroxanthenes显示文摘Ceric ammonium nitrate(CAN) supported HY-zeolite has been used as an efficient catalyst for the onepot synthesis of 1,8-dioxo-octahydroxanthenes from the readily available 1,3-diketone and aromatic aldehydes under solvent-free conditions.The present methodology is cost-effective in addition to other advantages like high yields of products in shorter reaction time and simple workup procedure without the use of any injurious solvents. | Paramasivam Sivaguru Appaswami Lalitha | 2014 | Chinese Chemical Letters2014，25，2： | 2 |
| 6 | Resistance of fibre concrete slabs to low velocity projectile impact显示文摘 | Ong K C Baxkeerkhan M Paramasivam P | 1999 | Cement & Concrete Composites1999，21，4： | 2 |
| 7 | Implications of m6A modification in autoimmune disorders显示文摘N6-Methyladenosine(m6A)is the most common and abundant modification of RNA molecules,including mRNAs,microRNAs(miRNAs),and long noncoding RNAs(lncRNAs).1 The m6A modification is catalyzed and dynamically regulated by recently discovered enzymes termed“writers”(methyltransferases including METTL3,METTL14,and WTAP),“erasers”(demethylases including FTO and ALKBH5)and“readers”(m6A-binding proteins including YTHDC1,YTHDC2,YTHDF1,YTHDF2,and YTHDF3).These modifications were recently shown to be involved in the regulation of different biological processes. | Arumugam Paramasivam Jayaseelan Vijayashree Priyadharsini Subramanian Raghunandhakumar | 2020 | Cellular & Molecular Immunology2020，17，5： | 2 |
| 8 | Modelling of rectangular RC columns strengthened with FRP 显示文摘 | Maalej M Tanwongsval S Paramasivam P | 2003 | Cement & Concrete Composite2003，，25： | 1 |
| 9 | MoO3 in Self-organized TiO2 Nanotubes for Enhanced Photocatalytic Activity 显示文摘 | Agarwal P Paramasivam I Shrestha N K | 2010 | Chem Asian J2010，5，1： | 1 |
| 10 | Analysis of the influence of grinding aids on the breakage process of calcite in media mills显示文摘 | Nair P Rajendran B Paramasivam R | 1999 | Advanced Powder Technology1999，10，3： | 1 |
| 11 | Ferrocement laminates for strengthening RC T- beams 显示文摘 | Paramasivam P Ong K C G Lim C T E | 1994 | Cement and Concrete Composites1994，16，2： | 1 |
| 12 | Flexural Strengthening of Reinforced Concrete Beams Using Ferrocement Laminate 显示文摘 | Ong K C G Paramasivam Lim C T E | 1992 | Journal of Ferrocement1992，，： | 1 |
| 13 | Determination of fipronil and its major metabolites in vegetables, fruit and soil using QuEChERS and gas chromatography-mass spectrometry显示文摘 | Mariappan Paramasivam S. Chandrasekaran | 2013 | International Journal of Environmental Analytical Chemistry2013，，11： | 1 |
| 14 | Role ofsediment characteristics on natural radiation level of the V aigairiver sediment, Tamilnadu, India显示文摘 | Ramasamy V Paramasivam K Suresh G | 2014 | Journal of EnvironmentalRadioactivity2014，127，： | 1 |
| 15 | Corrosion durability and structural response of functionally-graded concrete beams显示文摘 | MAALEJ M AHMED S F U PARAMASIVAM P | 2003 | Journal of Advanced Concrete Technology2003，1，3： | 1 |
| 16 | Dynamically Recon- figurable Controller for Three-Phase Voltage-Source lnverters 显示文摘 | Pongiannan R K Paramasivam S Yadaiah N | 2011 | IEEE Trans Power Electron2011，26，6： | 1 |
| 17 | Quantitative determination of recently fixed non -exchangeable ammonium in soils显示文摘 | PARAMASIVAM SBG | 2000 | Soil Science Society of America Journal2000，64，5： | 1 |
| 18 | Nitrogen management for highyield and quality of citrus in sandy soils显示文摘 | Alva A K Paramasivam S | 1998 | Soil Sci Soc AmJ1998，62，： | 1 |
| 19 | Prognostic impor- tance of preoperative CA - 125 in International Federation of Gyne- cology and Obstetric stage I epithelial ovarian cancer: an Australian multicenter study显示文摘 | Paramasivam S Tripcony L Crandon A | 2005 | J Clin Oncol2005，23，25： | 1 |
| 20 | Evaluation of the individuality of white rot macro fungus for the decolorization of synthetic dye显示文摘 | Priyanka Pandey Ram Praksh Singh Kailash Nath Singh Paramasivam Manisankar | 2013 | Environmental Science and Pollution Research2013，，1： | 1 |
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