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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | New microsatellite markers for the snow crab Chionoecetes opilio (Brachyura:Majidae) 显示文摘 | Puebla O Parent E Svigny J | 2003 | Molecular Ecology Notes2003，3，4： | 1 |
| 3 | Interverte-bral disk disease in dogs with signs of back pain alone:25cases(1986-1993)显示文摘 | Sukhiani H R Parent J M Atilola M A O | 1996 | Journal of the American Veterinary Medi-cal Association1996，209，： | 1 |
| 4 | 肺动脉高压启动治疗后血流动力学指标的预后价值显示文摘血流动力学指标,如心脏指数和右心房压力(right atrial pressure,RAP)与患者确诊肺动脉高压时的生存率持续相关。近期研究表明,肺动脉顺应性(pulmon aryarterial compliance,Pea)也可能预测肺动脉高压的预后。而在治疗开始之后测定的血流动力学指标对预后的价值还未确定。 | 黄洁 叶鹏 Weatherald J Boucly A Chemla D Savale L Peng M Jevnikar M Ja?s X Taniguchi Y O'Connell C Parent F Sattler C Hervé P Simonneau G Montani D Humbert M Adir Y Sitbon O | 2017 | 中华高血压杂志2017，25，11： | 1 |
| 5 | Using the variance structure of the conditional autoregressive spatial specification to model knowledge spillovers 显示文摘 | Parent O LeSage J P | 2008 | Journal of Applied E- conometrics2008，23，2： | 1 |
| 6 | Saturator analysis for an evaporative gas turbine cycle显示文摘 | PARENTE J O S TRAVERSO A MASSARDO A F | 2003 | Applied Thermal Engineering2003，23，10： | 1 |
| 7 | Determinants of knowledge produc- tion and their effects on regional economic growth 显示文摘 | Parent O LeSage J P | 2012 | Journal of Regional Science2012，52，： | 1 |
| 8 | Bayesian analysis of knowledge spiUovers in European regions 显示文摘 | PARENT O RIOU S | 2005 | Journal of Regional Science2005，，45： | 1 |
| 9 | Using the variance structure of the conditional autoregressive spatial specification to model knowledge spillovers 显示文摘 | Parent O LeSage J P | 2008 | Journal of Applied E- conometrics2008，23，2： | 1 |
| 10 | Tuber-wall catalytic reactor cooled by an annular heat pipe显示文摘 | Parent Y O Caram H S Coughlin R W | 1983 | AIChE Journal1983，29，3： | 1 |
| 11 | Documenting the staff perceptions of open ward family room units显示文摘 | Domanico R Davis D K Coleman NICU design versus single 30 (5) : 34 dilemma: Parent and F Davis B O | 2010 | Journal of Perinatology2010，3351，： | 1 |
| 12 | Long term imatinib treatment in pulmonary arterial hypertension 显示文摘 | Souza R Sitbon O Parent F | 2006 | Thorax2006，61，8： | 1 |
| 13 | Randomized controlled trial of recombinant alpha-2a-interferon for chronic hepatitis C显示文摘 | David D. Douglas MD Dr. Jorge Rakela MD Hsiang Ju Lin DSc F. Blaine Hollinger MD Howard F. Taswell MD Albert J. Czaja MD John B. Gross MD Monte L. Anderson MD Kevin Parent MD C. Richard Fleming MD John R. Cangemi MD Peter C. O’Brien PhD Pauline E. Powis R | 1993 | Digestive Diseases and Sciences1993，，4： | 1 |
| 14 | Char- acterization of Staphylococcus aureus isolates from buffalo, bo vine, ovine, and caprine milk samples collected in Rio de Janeiro State,Brazil 显示文摘 | Aires-de-Sousa M Parente C E Vieira-da-Motta O | 2007 | Appl Environ Microbiol2007，73，12： | 1 |
| 15 | Tuber-wall catalytic reactor cooled by an annular heat pipe显示文摘 | Parent Y O Caram H S Coughlin R W | 1983 | AICHE Journal1983，29，3： | 1 |
| 16 | Anti-icing and de-icing techniques for wind turbines:Critical review显示文摘 | PARENT O ILINCA A | 2011 | Cold Regions Science and Technology2011，65，1： | 1 |
| 17 | Saturator analysis for an evaporative gas turbine cycle显示文摘 | PARENTE J O S TRAVERSO A MASSARDO A F | 2003 | Applied thermal engineering2003，23，： | 1 |
| 18 | Behaviour of acid secretion,gastrin release,serum pepsinogen I,and gastric emptying of liquids over six months from eradication of helicobacter pylori in duodenal ulcer patients显示文摘 | Parente F1 Maconi G Sangaletti O | 1995 | Cut1995，，37： | 1 |
| 19 | The eatablishment of neisseria meningitides serogroup W135 of the clonal complex ET - 37/ST - 11 as an epidemic clone and the persistence of serogroup A isolates in Burkina Faso 显示文摘 | NJANPOP - LAFOURCADE B M PARENT DU CHATELET I SANOU O | 2005 | Microbes Infect2005，7，4： | 1 |
| 20 | Improvement of stress tolerance of wheat and barley by modulation of expression of DREB/ CBF factors 显示文摘 | Morran S Eini O Pyvovarenko T Parent B Singb R Ismagul A Eliby S Shirley N Langridge P Lopato S | 2011 | Plant Biotechnology Journal2011，9，2： | 1 |
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