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| 1 | Distribution of hepatitis B virus genotypes:Phylogenetic analysis and virological characteristics of Genotype C circulating among HBV carriers in Kolkata,Eastern India显示文摘AIM: To evaluate the genotype distribution of hepatitis B virus (HBV) in Eastern India and to clarify the phyloge- netic origin and virological characteristics of the recently identifi ed genotype C in this region. METHODS: Genotype determination, T1762/A1764 mutation in the basal core promoter (BCP) and A1896 mutation in the precore region of 230 subjects were de- termined by restriction fragment length polymorphism method (RFLP) and the result was confi rmed by direct sequencing. RESULTS: The predominant genotypes D (HBV/D) and A (HBV/A) were detected in 131/230 (57%) and 57/230 (25%) samples. In addition, genotype C (HBV/C) was detected in 42/230 (18%) isolates. Surface gene region was sequenced from 45 isolates (27 HBV/C, 9 HBV/A and 9 HBV/D). Phylogenetic analysis revealed that all of the HBV/C sequences clustered with South East Asian subgenotype (HBV/Cs). The sequence data showed re- markable similarity with a Thai strain (AF068756) (99.5% ± 0.4% nucleotide identities) in 90% of the genotype C strains analyzed. T1762/A1764 mutation in BCP re- gion, associated with high ALT was signifi cantly higher in HBeAg negative isolates than HBeAg positive isolates. Frequency of A1896 mutation leading to HBeAg negativ- ity was low.CONCLUSION: The present study reports the genotypic distribution and the characteristics of partial genome sequences of HBV/C isolates from Eastern India. Low genetic diversity and confi nement of HBV/C in Eastern India possibly indicate a recent, limited, spread in this region. Genotype C with T1762/A1764 mutation has been reported to increase the risk for hepatocellular car- cinoma; therefore genotype C carriers in Eastern India should be carefully monitored. | Arup Banerjee Sibnarayan Datta Partha K Chandra Susanta Roychowdhury Chinmoy Kumar Panda Runu Chakravarty | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 2 | 简易转速测量系统设计显示文摘介绍了一种基于定时器的转速测量系统的设计与开发。使用直流电动机的转轴来测量其转速,定时器IC 555用于不稳定模式。使用数字存储示波器(DSO)测量的定时器输出波形的频率几乎与转轴的转速成线性比例,而这个转速又与外部输入电压水平的变化成线性关系,由此得到了定时器输出波形频率与转速之间的线性关系。该系统的主要优点是线性输入-输出,体积小,便于携带且成本低。 | Akash Kumar Anindya Debnath Antar Banik Kabirul Islam Mondal Partha Pratim Biswas Rik Bhattacharyya T K Maiti | 2020 | Journal of Measurement Science and Instrumentation2020，11，2： | 2 |
| 3 | Hepatocellular carcinoma xenograft supports HCV replication:A mouse model for evaluating antivirals显示文摘AIM: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.METHODS: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice. We showed that the S3-GFP replicon cell line formed human HCC xenografts in SCID mice. Cells were isolated from subcutaneous tumors and then serially passaged multiple times in SCID mice by culturing in growth medium supplemented with G-418. The mouse-adapted S3-GFP replicon cells were implanted subcutaneously and also into the liver of SCID mice via intrasplenic infusion to study the replication of HCV in the HCC xenografts. The tumor model was validated for antiviral testing after intraperitoneal injection of interferon-α (IFN-α). RESULTS: A highly tumorigenic S3-GFP replicon cell line was developed that formed subcutaneous tumors within 2 wk and diffuse liver metastasis within 4 wk in SCID mice. Replication of HCV in the subcutaneous and liver tumors was confirmed by cell colony assay, detection of the viral RNA by ribonuclease protection assay and real-time quantitative reverse transcription polymerase chain reaction. High-level replication of HCV sub-genomic RNA in the tumor could be visualized by GFP expression using fluorescence microscopy. IFN-α cleared HCV RNA replication in the subcutaneous tumors within 2 wk and 4 wk in the liver tumor model. CONCLUSION: A non-infectious mouse model allows us to study replication of HCV in subcutaneous and metastatic liver tumors. Clearance of HCV by IFN-α supports use of this model to test other anti-HCV drugs. | Sidhartha Hazari Henry J Hefler Partha K Chandra Bret Poat Feyza Gunduz Tara Ooms Tong Wu Luis A Balart Srikanta Dash | 2011 | World Journal of Gastroenterology2011，17，3： | 2 |
| 4 | Microbially induced flocculation and flotation for pyrite separation from oxide gangue minerals显示文摘 | Partha Patra Natarajan K A | 2003 | Miner Eng2003，16，： | 1 |
| 5 | Microbially induced flocculation and flotation for separation of chalcopyrite from quartz and calcite显示文摘 | Partha Patra Natarajan K A | 2004 | Miner Process2004，74，： | 1 |
| 6 | Microbially induced flocculation and flotation of pyrite and sphalerite显示文摘 | Partha Patra Natarajan K A | 2004 | Colloids and Surfaces:B2004，36，： | 1 |
| 7 | The spectrum of thy- roid disorders in systemic Lupus erythematosus 显示文摘 | Kundan K ALakes K Partha S | 2010 | Rheuma- toL Int2010，25，： | 1 |
| 8 | Microbially induced flocculation and flotation for separation chalcopyrite from quartz and calcite显示文摘 | PARTHA P NATARAJAN K A | 2004 | International Journal of Mineral Processing2004，74，14： | 1 |
| 9 | Microbially induced flotation and t:locculation of pyrite and sphalerite显示文摘 | PARTHA P NATARAJAN K A | 2004 | Colloids and Surfaces : Biointerfaces2004，36，2： | 1 |
| 10 | Evaluation of the general motors based car- following models and a proposed fuzzy inference model 显示文摘 | Partha C Shinya K | 1999 | Transportation Research Part C1999，7，： | 1 |
| 11 | Clouding behaviour in surfactant systems显示文摘 | Partha M Susanta K P Sukalyan D | 2011 | Advances in Colloid and Interface Science2011，162，12： | 1 |
| 12 | Modeling of electrical discharge machining process using back propagation neural network and multi-objective optimization using non- dominating sorting genetic algorithm-II显示文摘 | Debabrata Mandal Surjya K Pal Partha Saha | 2007 | Journal of Materials Processing Technology2007，，186： | 1 |
| 13 | The specificity of pro- tection against cationic antimicrobial peptides by lactoferrin binding protein B 显示文摘 | Morgenthau A Partha S K Adamiak P | 2014 | Biometals2014，27，5： | 1 |
| 14 | Role of mineral specificbacterial proteins in selective flocculation and flotation显示文摘 | Partha Patra K A Natarajan | 2008 | Int J Miner Process2008，，88： | 1 |
| 15 | The posterior reversible encepha- lopathy syndrome 显示文摘 | Sanjay K M Partha P C | 2008 | Indian J Pediatr2008，75，9： | 1 |
| 16 | Microbially induced flocculation and flotation for separation of chalcopyrite from quartz and calcite显示文摘 | Partha P Natarajan K A | 2004 | International Journal of Mineral Processing2004，74，： | 1 |
| 17 | Modeling of electrical discharge machining process using back propagation neural network and multi-objective optimization using non-dominating sorting genetic algorithm-Ⅱ显示文摘 | Debabrata Mandal Surjya K Pal Partha Saha | 2007 | Journal of Materials Processing Technology2007，186，： | 1 |
| 18 | Genetical studies on roots in bread wheat显示文摘 | Partha D A S Ali M N Sarkar H K | 2004 | Journal of Interacademicia2004，8，2： | 1 |
| 19 | Placement of wind and solar based DGs in distribution system for power loss minimiza- tion and voltage stability improvement 显示文摘 | Partha K C K Chanda | 2013 | International Journal of Electrical Power and Energy Systems2013，53，： | 1 |
| 20 | Effect of Nb and Cr incorporation on the structural and magnetic properties of rapidly quenched FeCoSiB microwires 显示文摘 | Partha S Roy R K Mitra A | 2012 | J Magn Magn Mater2012，324，： | 1 |
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