4篇
您的检索式：作者名="Patrick Gunther"
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| 1 | 活性炭在吸附猪体内呕吐毒素(DON)上的功效显示文摘为了评估霉菌毒素吸附剂在动物体内的功效,根据欧洲的相关指南应该测量其特定的毒物代谢动力学参数。出于此目的,研究人员着重介绍了猪吸收模型的吸收动力学。在该模型中,试验猪单独或与活性碳(用作霉菌毒素的粘合剂)一起口服大丸粒霉菌毒素——呕吐毒素(DON)。在单独喂给呕吐毒素后,可从猪的血液中检测到了高水平的呕吐毒素,并用房室模型(compartmental model)计算霉菌毒素在体内的动力学参数。活性炭能够彻底防止呕吐毒素的吸收,因为呕吐毒素与活性碳同时喂给猪后,未能从猪体内检测到该毒素。 | 邵建忠 潘雪男 Mathias Devreese Gunther Antonissen Patrick De Backer Siska Croubels | 2015 | 国外畜牧学(猪与禽)2015，0，5： | 6 |
| 2 | GOBO projection for 3D measurements at highest frame rates: a performance analysis显示文摘Aperiodic sinusoidal patterns that are cast by a GOBO(GOes Before Optics)projector are a powerful tool for optically measuring the surface topography of moving or deforming objects with very high speed and accuracy.We optimised the first experimental setup that we were able to measure inflating car airbags at frame rates of more than 50 kHz while achieving a 3D point standard deviation of~500μm.Here,we theoretically investigate the method of GOBO projection of aperiodic sinusoidal fringes.In a simulation-based performance analysis,we examine the parameters that influence the accuracy of the measurement result and identify an optimal pattern design that yields the highest measurement accuracy.We compare the results with those that were obtained via GOBO projection of phase-shifted sinusoidal fringes.Finally,we experimentally verify the theoretical findings.We show that the proposed technique has several advantages over conventional fringe projection techniques,as the easy-to-build and cost-effective GOBO projector can provide a high radiant flux,allows high frame rates,and can be used over a wide spectral range. | Stefan Heist Patrick Dietrich Martin Landmann Peter Kühmstedt Gunther Notni Andreas Tünnermann | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 3 | The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin显示文摘 | Susanne V Schmidt Wolfgang Krebs Thomas Ulas Jia Xue Kevin BalBer Patrick Gunther Anna-Lena Hardt Hartmut Schultze Jil Sander Kathrin Klee Heidi Theis Michael Kraut Marc Beyer Joachim L Schultze | 2016 | Cell Research2016，26，2： | 1 |
| 4 | RIG-I immunotherapy overcomes radioresistance in p53-positive malignant melanoma显示文摘Radiotherapy induces DNA damage,resulting in cell cycle arrest and activation of cell-intrinsic death pathways.However,the radioresistance of some tumour entities such as malignant melanoma limits its clinical application.The innate immune sensing receptor retinoic acid-inducible gene I(RIG-I)is ubiquitously expressed and upon activation triggers an immunogenic form of cell death in a variety of tumour cell types including melanoma.To date,the potential of RIG-I ligands to overcome radioresistance of tumour cells has not been investigated.Here,we demonstrate that RIG-I activation enhanced the extent and immunogenicity of irradiation-induced tumour cell death in human and murine melanoma cells in vitro and improved survival in the murine B16 melanoma model in vivo.Transcriptome analysis pointed to a central role for p53,which was confirmed using p53^(-/-)B16 cells.In vivo,the additional effect of RIG-I in combination with irradiation on tumour growth was absent in mice carrying p53^(-/-)B16 tumours,while the antitumoural response to RIG-I stimulation alone was maintained.Our results identify p53 as a pivotal checkpoint that is triggered by RIG-I resulting in enhanced irradiation-induced tumour cell death.Thus,the combined administration of RIG-I ligands and radiotherapy is a promising approach to treating radioresistant tumours with a functional p53 pathway,such as melanoma. | Silke Lambing Yu Pan Tan Paraskevi Vasileiadou Stefan Holdenrieder Patrick Müller Christian Hagen Stephan Garbe Rayk Behrendt Martin Schlee Jasper G.van den Boorn Eva Bartok Marcel Renn Gunther Hartmann | 2023 | Journal of Molecular Cell Biology2023，15，1： | 0 |
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