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| 1 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 2 | Comparative analysis of open and laparoscopic colectomy for malignancy in a developing country显示文摘AIM: To compare the short-term, including oncologic, outcomes of open vs laparoscopic colectomy for cancer in a developing country. METHODS: The records of patients who underwent elective open and laparoscopic colectomies for cancer at the University Hospital of the West Indies between January 2005 and December 2010 were retrospectively reviewed. Demographic(age, gender, Charlson comorbidity index score), peri-operative, post-operative and oncologic data were collected for each patient. Specific oncologic variables included lymph node yield, pathologic stage, grade, proximal, distal and circumferential margin involvement. Fisher's exact, Mann-Whitney, and binary logistic regression tests were used for analysis. Significance level was set atP < 0.05. RESULTS: There were 87 cases for open colectomy(OC) and 17 cases for laparoscopic colectomy(LC). Demographics did not significantly differ between OC and LC groups. Intra-operative blood loss and postoperative analgesic requirements did not significantly differ between groups. There was a trend towards longer operating times in OC group and shorter hospital stay in the LC group. Lymph node yield(14 vs 14, P = 0.619), proximal(10 cm vs 7 cm, P = 0.353) and distal(8 cm vs 8 cm, P = 0.57) resection margin distance and circumferential margin involvement(9 vs 0, P = 0.348) did not significantly differ between groups. Thirty-day morbidity was equivalent between groups(22 vs 6, P = 0.774). There were 6 deaths within 30 d of initial procedure, all in the OC group(6.9%). CONCLUSION: Laparoscopic colectomy in a developing country is oncologically safe and represents a option for colonic malignancies in these regions. Such data encourage the continued laparoscopic development. | Pierre-Anthony Leake Kristen Pitzul Patrick O Roberts Joseph M Plummer | 2013 | World Journal of Gastrointestinal Surgery2013，5，11： | 8 |
| 3 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 4 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 5 | Broad-Spectrum mildew resistance in Arabidopsis thaliana mediated by RPW8 显示文摘 | Xiao Shunyuan Simon E Calis O Patrick E Li Tianxian Coleman M | 2001 | Science2001，291，5： | 1 |
| 6 | Role of the p53 tumor suppressor gene in Cell cycle arrest and radiosensitivity of Burkitt's lymphoma eell lines显示文摘 | Patrick M O'Connor Jackman J | 1993 | Cancer Res1993，53，： | 1 |
| 7 | Prony' s method: an efficient tool for the analysis of earth fault currents in Petersen-coil-protected networks显示文摘 | Chaari O Patrick B Michel M | 1995 | IEEE Trans on Power Delivery1995，10，3： | 1 |
| 8 | Multiple independent emer- gences of type 2 vaccine-derived polioviruses during a large outbreak in northern Nigeria显示文摘 | Burns C C Shaw J Jorba J Bukbuk D Adu F Gumede N Pate M A Abanida E A Gasasira A Iber J Chen Q Vincent A Chenoweth P Henderson E Wannemuehler K Naeem A Umarni R N Nishimura Y Shimizu H Baba M Adeniji A Williams A J Kil- patrick D R Oberste M S Wassilak S G Tomori O Pallansch M A Kew O | 2013 | J Virol2013，87，9： | 1 |
| 9 | Effect of the wa ter acidifier 810 SAVORTM on post weaning pig performance 显示文摘 | Morrow W E M Hansen J A Patrick O Q | 1995 | Swine Health and Production1995，3，4： | 1 |
| 10 | Oxygen sensor based on the fluorescence quenching of a ruthenium complex immobilized in a jbiocompatible poly ( ethylene glycol ) hydrogel 显示文摘 | PATRICK D O' Neal MELEDEO M Adam JUSTIN R Davis | 2004 | IEEE Sensor Journal2004，，4： | 1 |
| 11 | A multi-agent systems app- roach to distributed bayesian information fusion显示文摘 | Gregor P Patrick O Marinus M etal | 2010 | Information Fusion2010，，11： | 1 |
| 12 | Method for detecting classes of microcystins by combination of protein phosphatase inhibition assay and ELISA:comparison with LC-MS显示文摘 | Douglas O M Patrick H Jan S | 2005 | Toxicon2005，45，： | 1 |
| 13 | Schepers use of chloro- phyll fluorescence assessments to differentiate corn hy- brid response to variable water conditions显示文摘 | Patrick M O'Neill John F | 2006 | Crop Sci2006，46，： | 1 |
| 14 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O’Connor Rodica Pop-Bus | 2010 | 2010 (9739)2010，，9739： | 1 |
| 15 | Diagnostic and prognostic value of circulating D-Dimer in patients with acute aortic dissection显示文摘 | Patrick O Antoine F Olivier M | 2006 | Crit Care Med2006，34，15： | 1 |
| 16 | Method for detecting classes of microcystins by combination of protein phosphatase inhibition assay and ELISA: Comparison with LC-MS显示文摘 | Douglas O M Patrick H Jan S | 2005 | Toxicon2005，45，2： | 1 |
| 17 | The formation of ammonia in air-blown gasification: Does char-derived NO act as a precursor 显示文摘 | AMURE O HANSON S CLOKE M PATRICK J W | 2003 | Fuel2003，82，17： | 1 |
| 18 | A Procedure for Regional Lake Water Clarity Assessment Using Landsat Multispectral Data显示文摘 | Steven M K Patrick L B Leif G O | 2002 | Remote Sensing of Environment2002，82，： | 1 |
| 19 | Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility显示文摘 | Julius G Patrick S Daniel F G Thorarinn B Arnaldur G Bjarni A A Kristrun R B Droplaug N M Gudbjorg O Margret J | 2009 | Nature Genetics2009，41，10： | 1 |
| 20 | Sequential administration of camptothecin and etoposide circumvents the antagonistic cytotoxicity of simultaneous drug administration in slowly growing human colon carcinoma HT-29 cells显示文摘 | Richard Bertrand Patrick M O'Connor Donna Kerrigan | 1992 | European Journal of Cancer1992，28，4： | 1 |
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