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| 1 | Effectiveness of exercise in hepatic fat mobilization in nonalcoholic fatty liver disease: Systematic review显示文摘AIM: To investigate the efficacy of exercise interventions on hepatic fat mobilization in non-alcoholic fatty liver disease(NAFLD) patients.METHODS: Ovid-Medline, Pub Med, EMBASE and Cochrane database were searched for randomized trials and prospective cohort studies in adults aged ≥ 18 which investigated the effects of at least 8 wk of exercise only or combination with diet on NAFLD from 2010 to 2016. The search terms used to identify articles, in which exercise was clearly described by type, duration, intensity and frequency were: 'NASH', 'NAFLD', 'nonalcoholic steatohepatitis', 'non-alcoholic fatty liver disease', 'fat', 'steatosis', 'diet', 'exercise', 'MR spectroscopy' and 'liver biopsy'. NAFLD diagnosis, as well as the outcome measures, was confirmed by either hydrogen-magnetic resonance spectroscopy(H-MRS) or biopsy. Trials that included dietary interventions along with exercise were accepted if they met all criteria. RESULTS: Eight studies met selection criteria(6 with exercise only, 2 with diet and exercise with a total of 433 adult participants). Training interventions ranged between 8 and 48 wk in duration with a prescribed exercise frequency of 3 to 7 d per week, at intensities between 45% and 75% of VO2 peak. The most commonly used imaging modality was H-MRS and one study utilized biopsy. The effect of intervention on fat mobilization was 30.2% in the exercise only group and 49.8% in diet and exercise group. There was no difference between aerobic and resistance exercise intervention, although only one study compared thetwo interventions. The beneficial effects of exercise on intrahepatic triglyceride(IHTG) were seen even in the absence of significant weight loss. Although combining an exercise program with dietary interventions augmented the reduction in IHTG, as well as improved measures of glucose control and/or insulin sensitivity, exercise only significantly decreased hepatic lipid contents.CONCLUSION: Prescribed exercise in subjects with NAFLD reduces IHTG independent of dietary intervention. Diet and exercise was more effective than exercise alone in reducing IHTG. | Pegah Golabi Cameron T Locklear Patrick Austin Sophie Afdhal Melinda Byrns Lynn Gerber Zobair M Younossi | 2016 | World Journal of Gastroenterology2016，22，27： | 30 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | Stability of silico-ferrite of calcium and aluminum (SFCA) in air-solid solution lim- its between 1240 degrees C and 1390 degrees C and phase relationships within the Fe203-CaO-Al2O2-SiO2 (FCAS) system显示文摘 | Patrick T R C Pownceby M I | 2002 | Metallurgical and Materials Transac- tions B-Process Metallurgy and Materials Processing Sci-ence2002，33，1： | 1 |
| 4 | Preferred risk allocation in target cost contracts in con- struction显示文摘 | Joseph H L Chan Daniel W M Chan Patrick T I Lam | 2011 | Facilities2011，29，1314： | 1 |
| 5 | Measuring system of systems per-formance显示文摘 | Thomas J M Patrick T H | 2012 | International Journal of System of Systems Engi neering2012，3，3： | 1 |
| 6 | 5-Nitro-2-thiophene-aldehyde显示文摘 | Patrick T M Emerson W S | 1952 | J Am Chem Soc1952，74，： | 1 |
| 7 | Sesquiterpenes from clove (Eugenia caryophyllata) as potential antlcarcinogenie agents显示文摘 | Zheng G Q Patrick M K Luke K T L | 1992 | J Natur Pro1992，55，7： | 1 |
| 8 | The impact of pyrro lidine hydroxylation on the conformation of proline containing peptides显示文摘 | CAROL M T RENAUD H PATRICK J B | | 0，，： | 1 |
| 9 | Salmonella Enteritidis Infections,United States,1985-1999显示文摘 | PATRICK M E ADCOCK P M GOMEZ T M | 2004 | Emerg Infect Dis2004，10，1： | 1 |
| 10 | Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene☆显示文摘 | Victor R Gordeuk Angela Caleffi Elena Corradini Francesca Ferrara Russell A Jones Oswaldo Castro Onyinye Onyekwere Rick Kittles Elisa Pignatti Giuliana Montosi Cinzia Garuti Innocent T Gangaidzo Z.A.R Gomo Victor M Moyo Tracey A Rouault Patrick MacPhail A | 2003 | Blood Cells Molecules and Diseases2003，，3： | 1 |
| 11 | SJES14110700138146显示文摘 | Michael Manns Stanislas Pol Ira M Jacobson Patrick Marcellin Stuart C Gordon Cheng-Yuan Peng Ting-Tsung Chang Gregory T Everson Jeong Heo Guido Gerken Boris Yoffe William J Towner Marc Bourliere Sophie Metivier Chi-Jen Chu William Sievert Jean-Pierre Bron | 2014 | The Lancet2014，，9954： | 1 |
| 12 | Stability of Silico Ferrite of Calcium and Aluminum (SFCA) in Air Solid Solution Limits Between 1 240 ℃ and 1 390 ℃ and Phase Relationships Within the Fe2O3-CaO Al2O3 SiO2 (FCAS) System 显示文摘 | Patrick T R C Pownceby M I | 2002 | Metallurgical and Materials Transactions2002，33，： | 1 |
| 13 | Choosingbetween green innovative technologies-hydrothermalprocessing of biowastes显示文摘 | Svanstrom M Patrick T N Froling M | 2007 | Journal of AdvancedOxidation Technologies2007，10，1： | 1 |
| 14 | A Method for Calibrating Deterministic Forecasts of Rare Events显示文摘 | Marsh Patrick T Kain John S Lakshmanan Valliappa Clark Adam J Hitchens Nathan M Hardy Jill | 2012 | EN2012，，2： | 1 |
| 15 | Study of Diarrhea in Critically III Patients显示文摘 | Kelly T W Patrick M R Hillman K M | 1983 | Crit Care Med1983，11，1： | 1 |
| 16 | Tacrolimus phenytoin interaction显示文摘 | Coleman A M | 1996 | The Annals of Pharmacotherapy1996，30，： | 1 |
| 17 | RARβ2 specificity in mediationg RA inhibition of growth of lung cancer-derived cells显示文摘 | Andre T Johane M Patrick AD | 2000 | Lung Cancer2000，28，： | 1 |
| 18 | Factors Influencing Pain Management by Nurses in Emer- gency Departments in Central Africa显示文摘 | Rampanjato R M Florence M Patrick N C Finucane B T | 2007 | Emerg Med J2007，24，7： | 1 |
| 19 | Species-specific PCR-based assays for the detection of Fusarium species and acomparison with the whole seed agar plate method and trichothecene analysis显示文摘 | Derneke T Clear R M Patrick S K | 2005 | International Journal of Food Microbiology2005，103，： | 1 |
| 20 | Resistance of Human Hepatitis Delta Virus RNAs to Dicer Activity显示文摘 | PATRICK P JOHN M T | 2003 | J Virol2003，77，11： | 1 |
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