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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention显示文摘 | Pascalle S Monraats Yue Fang Douwe Pons Nuno MM Pires Huibert AP Pols Aeilko H Zwinderman Moniek PM de Maat Pieter AF Doevendans Robbert J deWinter René A Tio Johannes Waltenberger Rune R Frants Paul HA Quax Arnoud van der Laarse Ernst E van der Wall Andr | 2010 | Expert Opinion on Therapeutic Targets2010，，： | 1 |
| 3 | Physiology of local reninangiotensin systems显示文摘 | Paul M Mehr AP Kreutz R | 2006 | Physiol Rev2006，86，3： | 1 |
| 4 | Physiology of local renin-angiotensin systems 显示文摘 | Paul M Mehr AP Kreutz R | 2006 | Physiol Rev2006，86，10： | 1 |
| 5 | Perceived information security, financial liability and consumer trust in electronic commerce transactions显示文摘 | Ramnath KC Paul AP | 2002 | Logistics Information Management2002，15，56： | 1 |
| 6 | Avian and pandemic influenza: an overview显示文摘 | Gregory AP Robert MJ Paul VT | 2007 | Vaccine2007，25，6： | 1 |
| 7 | Comparison of the protective activities generated by two survival proteins:Bcl-2 and Hsp27 in L929 murine fibroblasts exposed to menadione or staurosporine显示文摘 | Paul C Arrigo AP | 2000 | Exp Gerontol2000，35，67： | 1 |
| 8 | Physiology of local reninangiotensin systems显示文摘 | Paul M Mehr AP Kreutz R | 2006 | Physiol Rev2006，86，： | 1 |
| 9 | Suitability of self-collected vaginal samples for Cervical Cancer screening in periutban villages in Andhra Pradesh, India 显示文摘 | Sowjanya AP Paul P Vedantham H | 2009 | Cancer Epidemiol Biomarkers Prev2009，18，5： | 1 |
| 10 | Scar assessment tools:implications for current research 显示文摘 | Paul PM Angeles AP Kreis RW | 2002 | Plast Reconstr Surg2002，109，3： | 1 |
| 11 | Small stress proteins : modulation of intracellular redox state and protection against oxidative stress 显示文摘 | Arrigo AP Paul C Ducasse C | 2002 | Prog Mol Subcell Biol2002，28，： | 1 |
| 12 | Cytotoxic effects induced by oxidative stress in cultured mammalian cells and protection provided by HSP27 expression 显示文摘 | Arrigo AP Firdaus W J Mellier G Moulin M Paul C Diaz-latoud C | 2005 | Methods2005，35，2： | 1 |
| 13 | Small stress proteins:modulation of intracellular redox state and protection against oxidative stress显示文摘 | Arrigo AP Paul C Ducasse C | 2002 | Prog Mol Subcell Biol2002，28，： | 1 |
| 14 | Amphiregulin causes functional downregulation of adherens junctions in psoriasis显示文摘 | Eunkyung C Paul WC Charles AP | 2005 | J Invest Dermatol2005，124，6： | 1 |
| 15 | Folic acid:neurochemistry,metabolism and relationship to depression显示文摘 | Paul RT McDonnell AP Kelly CB | 2004 | Hum Psychopharmacol2004，19，7： | 1 |
| 16 | Primary angiosan'oma of the lung 显示文摘 | Sameer AP Paul NF Jack LW | 2005 | Annals of Diagnostic Pathology2005，5，9： | 1 |
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