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| 1 | 他汀、高密度脂蛋白胆固醇与冠状动脉粥样硬化消退显示文摘背景:他汀类药物可以降低低密度脂蛋白胆固醇(low—density lipoprotein cholesterol,LDL—C)水平并减缓冠状动脉粥样硬化的进展。然而,对于他汀类药物所致高密度脂蛋白胆固醇(high—density lipoprotein cholesterol,HDL—C)变化与疾病进展的关系,目前仍无相关数据描述。目的:了解LDL—C和HDL—C水平变化与动脉粥样硬化的相互关系。设计、地点及患者:对4项前瞻性随机试验(1999~2005年在美国、北美、欧洲和澳大利亚进行)的原始数据进行事后分析。其中1455例经血管造影证实的冠心病患者在接受他汀治疗(18个月或24个月)时进行了系列血管内超声扫描。所有超声分析均在相同的核心实验室中进行。主要观测指标:脂蛋白水平变化与冠状动脉粥样斑块体积的相互关系。结果:他汀治疗期间,LDL—C平均(SD)水平从124.0(38.3)mg,/dL(3.2[0.99]mmol/L)降至87.5(28.8)mg,/dL(2.3[0.75]mmol/L)(下降23.5%;P〈0.001),HDL—C水平从42.5(11.0)mg/dL(1.1[0.28]mmol/L)升至45.1(11.4)mg/dL(1.2[0.29]mmol/L)(上升7.5%;P〈0.001)。LDL—C与HDL—C比值从平均(SD)3.0(1.1)降至2.1(0.9)(下降26.7%;P〈0.001)。这些变化同时伴随平均(SD)百分粥样斑块体积的增加(从39.7%[9.8%]增至40.1%[9.7%])(增加0.5%[3.9%];P=0.001)以及平均(SD)总粥样斑块体积的减小(2.4[23.6]mm^3;P〈0.001)。在单变量分析中,LDL—C、总胆固醇、非HDL胆固醇、载脂蛋白B以及载脂蛋白B与载脂蛋白A-1比值平均水平和治疗引起的变化与动脉粥样硬化进展速率显著相关,而治疗所致HDL—C变化则与动脉粥样斑块体积负相关。在多变量分析中,平均LDL—C水平(β系数,0.11[95%可信区间,0.07~0.15])以及HDL—C升高(β系数,-0.26[95%可信区间,-0.41--0.10])依然为动脉粥样硬化消退的独立预测因子。动脉硬化显著消退(动脉粥样斑块体积减少≥5%)见于治疗期间LDL—C水平低于均值(87.5mg/dL)和HDL—C升高百分比大于均值(7.5%;P〈0.001)的患者。临床事件的发生未见显著差异。结论:在LDL—C显著降低以及HDL上升〉7.5%时,他汀治疗与冠状动脉粥样硬化消退相关。这些结果提示他汀治疗的获益源自致动脉粥样硬化脂蛋白的降低以及HDL.C的升高。尽管血脂水平的这些变化与动脉粥样硬化消退相关,但是后者是否可以转化为临床事件的显著减少,并改善临床预后仍有待进一步研究确定。 | Stephen J. Nicholls, MBBS, PhD E. Murat Tuzcu, MD IIke Sipahi, MD Adam W. Grasso, MD Paul Schoenhagen, MD Tingfei Hu, MS Kathy Wolski, MPH Tim Crowe, BS Milind Y. Desai, MD Stanley L. Hazen, MD, PhD Samir R. Kapadia, MD Steven E. Nissen, MD 李呈亿(译) | 2007 | 美国医学会杂志(中文版)2007，26，3： | 48 |
| 2 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 3 | Thermal Enhancement of New Chemotherapeutic Agents at Moderate Hyperthermia显示文摘 | Faheez Mohamed MBChB MRCS Pierre Marchettini MD O. Anthony Stuart BS M. Urano MD Paul H. Sugarbaker MD FACS FRCS | 2003 | Annals of Surgical Oncology2003，，4： | 3 |
| 4 | Safety monitoring of the coliseum technique for heated intraoperative intraperitoneal chemotherapy with mitomycin C显示文摘 | O. Anthony Stuart BS Arvil D. Stephens BS Laura Welch MD Paul H. Sugarbaker MD | 2002 | Annals of Surgical Oncology2002，，2： | 2 |
| 5 | The biology of NKT cells 显示文摘 | Albert B Paul BS Luc T | 2007 | Annu Rev ImmunoL2007，25，： | 1 |
| 6 | Levels of Expression of P-Selectin, E-Selectin, and Intercellular Adhesion Molecule-1 in Coronary Atherectomy Specimens from Patients With Stable and Unstable Angina Pectoris显示文摘 | Alan N Tenaglia MD Andrew J Buda MD Robert G Wilkins MD Michael K Barron MD Paul R Jeffords BS Khoa Vo BS Maureen O Jordan BS Barry A Kusnick MD David J Lefer PhD | 1997 | The American Journal of Cardiology1997，，6： | 1 |
| 7 | Purification and che-mical modifications of hemoglobin in developing hemoglobin based oxygen carriers显示文摘 | Chad R Haney BS Paul W | 2000 | Advanced Drug Delivery Reviews2000，40，3： | 1 |
| 8 | New markers of inflammation and endothelial cell activation显示文摘 | Paul E Szmitko BS Wang CH | 2003 | Circulation2003，108，19： | 1 |
| 9 | Errors in orthognathic surgery planning: the effect of inaccurate study model orientation显示文摘 | Barbenel JC Paul PE Khambay BS | 2010 | Int J Oral Maxillofac Surg2010，39，11： | 1 |
| 10 | Subcortical gray matter N-acetylaspartate eduction in two cases of vascular dementia显示文摘 | Douraied BS Paul MW Guy-victor O | 2003 | J Clin Imaging2003，27，6： | 1 |
| 11 | Lymphocytic (microscopic) colitis显示文摘 | Dr. Francis M. Giardiello MD Audrey J. Lazenby MD Theodore M. Bayless MD Edward J. Levine MD Wilma B. Bias PhD Paul W. Ladenson MD David F. Hutcheon MD Nancy L. Derevjanik BS John H. Yardley MD | 1989 | Digestive Diseases and Sciences1989，，11： | 1 |
| 12 | Endothelin-1:Apotent vascular peptide显示文摘 | Valcrie BS Paul MV | 1991 | Pharmacol Toxico1991，69，： | 1 |
| 13 | Beta-defensins and LL-37 in bronchoalveolar lavage fluid of patients with cystic fibrosis显示文摘 | Chen CI Schaller BS Paul KP | 2004 | J Cyst Fibros2004，3，1： | 1 |
| 14 | The interaction of UVA and UVB in the produc-tion of threshold erythema显示文摘 | Paul BS Parrish JA | 1982 | J Invest Dermatol1982，78，5： | 1 |
| 15 | Combined PET/CT imaging in oncology impact on patient management显示文摘 | Paul G Kluetz BS Carolyn CM | 2000 | Clin Positronimag2000，3，6： | 1 |
| 16 | A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression显示文摘 | Carlos AZ Jaskaran BS Paul JC | 2006 | Arch Gen Psychiatry2006，63，： | 1 |
| 17 | Snake bite and stroke: Our experience of two cases显示文摘 | Paul G Paul BS Puri S | 2014 | Indian J Crit Care Meal2014，18，4： | 1 |
| 18 | Histopathologic Characteristics, Recurrence Patterns, and Survival of 129 Patients With Desmoplastic Melanoma显示文摘 | Katherine E. Posther MD M. Angelica Selim MD Paul J. Mosca MD PhD Wilma E. Stanley BS Jeffrey L. Johnson MS Douglas S. Tyler MD Hilliard F. Seigler MD | 2006 | Annals of Surgical Oncology2006，，5： | 1 |
| 19 | Physician surveys to assess customary care in medical malpractice cases显示文摘 | Dr. Arthur Hartz MD PhD Joshua Lucas BS Timothy Cramm MD Michael Green JD Suzanne Bentler MS John Ely MD MSPH Steven Wolfe MD Paul James MD | 2002 | Journal of General Internal Medicine2002，，7： | 1 |
| 20 | The big finger: the second tofourth digit ratio is a predictor of sporting ability in women 显示文摘 | Paul SN Kato BS Hunkin JL | 2006 | Br JSports Med2006，40，12： | 1 |
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