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10篇 您的检索式：作者名="Paul CW"

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		题名	作者	年代	出处	被引量
	1	Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC.	Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson	2005	World Journal of Gastroenterology2005，11，42：	4
	2	Who Advised the Hong Kong Government? The Politics of Absorption before and after 1997显示文摘	Cheung Anthony BL Paul CW Wong		0，，06：	1
	3	Intake and sources of phyUoquinone (vitamin K1):variation with socio-demographic and lifestyle factors in a national sample of British elderly people显示文摘	Thane CW Paul AA Bates C J	2002	BrJ Nutr2002，87，7：	1
	4	Renal replacement therapy for diabetic end- stage Disease, Data from registries Europe( 1991 -2000 )显示文摘	Paul CW Van D Kitty J	2005	Kidney Int2005，67，4：	1
	5	(2002) Intake and sources of phylloquinone(vitamin K1) variation with socio-demographic and lifestyle factors in a national sample of British Survey of elderly people显示文摘	Thane CW Paul AA Bates CJ	2002	Brit J Nutr2002，87，：	1
	6	Effect of acute dietary standardization on the urinary,plasma,and salivary metabolomic profiles of healthy humans显示文摘	Marianne CW Lorraine B J Paul G Malthouse Helen MR Michael JG		0，，：	1
	7	Intake and sources of phylloquinone (vitamin K1) variation with socio -demographic and lifestyle factorsin a national sample of British Survey of elderly people 显示文摘	Thane CW Paul AA Bates CJ	2002	Br J Nutr2002，87，：	1
	8	Intake and sources of phylloquinone (vitamin K1): variation with socio-demographic and lifestyle factors in a national sample of British elderlypeople显示文摘	Thane CW Paul AA Bates CJ	2002	Br J Nutr2002，87，6：	1
	9	Robust automated tumour seg- mentation on histological and immunohistochemical tissue images显示文摘	Wang CW Fennell D Paul I	2011	PLoS One2011，6，2：	1
	10	Laparoscopic resection of rectosigmoid carcinoma: prospective randomised trial显示文摘	Ka Lau Leung Samuel PY Kwok Steve CW Lam Janet FY Lee Raymond YC Yiu Simon SM Ng Paul BS Lai Wan Yee Lau	2004	2004 (9416)2004，，9416：	1

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