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| 1 | Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs显示文摘Objective:To evaluate in ritro antimicrobial activities of selected 58 ethno-medicinal plant extracts with a view to assess their therapeutic potential.Methods:A total of 58 traditional Chinese medicinal plants were carefully selected based on the literature review and their traditional use.The antimicrobial activities of ethanol extracts of these medicinal plants were tested against fungi(Aspergillus funigaius),yeast(Candida albicans),gram-negative(Acirelobacter haumannii and Pseudornnruis aeruginosa)and gram-positive bacteria(Staphglococcus aureus).The activities were tested at three different concentrations of 1.00,0.10 and 0.01 mg/mL.The data was analysed using Gene data Screener program.Results:The measured antimicrobial activities indicated that out of the 58 plant extracts,15 extracts showed anti-fungal activity and 23 extracts exhibited anti-bacterial activity.Eight plant extracts have exhibited both anti-bacterial and anti-fungal activities.For instance,Eucommia ulmoides,Pohgonum cuspidcrtum,Poria cocas and Uncaria rhineophylla showed activity against both bacterial and fungal strains,indicating their broad spectrum of activity.Conclusions:The results revealed that the ethanol extracts of 30 plants out of the selected 58 possess significant antimicrobial activities.It is interesting to note that the findings from the current study are consistent with the traditional use.A clear correlation has also been found between the antimicrobial activity and the flavonoid content of the plant extracts which is in agreement with the literature.Hence.the results presented here can be used to guide the selection of potential plant species for the isolation and structure elucidation of novel antimicrobial compounds in order to establish the structure-activity relationship.This in turn is expected to lead the way to the discovery of novel antimicrobial agents for therapeutic use. | Lin Zhang Anjaneya S.Ravipati Sundar R Koyyalamudi Sang Chul Jeong Narsimha Reddy John Bartlett Paul T.Smith Mercedes de la Cruz Maria Cndida Monteiro ngeles Melguizo Ester Jimnez Francisca Vicente | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，9： | 23 |
| 2 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 3 | Angiostatin inhibits endothelial MMP-2 and MMP-14 expression: A hypoxia specific mechanism of action显示文摘 | Aneta Radziwon-Balicka Corey Ramer Cesar Moncada de la Rosa Barbara Zielnik-Drabik Paul Jurasz | 2012 | Vascular Pharmacology2012，，： | 2 |
| 4 | SINGLE-01: a randomized, controlled trial comparing the efficacy and depth of insertion of single- and double-balloon enteroscopy by using a novel method to determine insertion depth显示文摘 | Marios Efthymiou Paul V. Desmond Gregor Brown Richard La Nauze Arthur Kaffes Tee Joo Chua Andrew C.F. Taylor | 2012 | Gastrointestinal Endoscopy2012，，5： | 2 |
| 5 | Randomized controlled trial of an internet- based intervention using ran dora digit dial recruitment: the disaster recovery web pro ject 显示文摘 | Ruggiero KJ Resnick HS Paul LA | 2012 | Contemporary Clinical Trials2012，33，1： | 1 |
| 6 | Determination of aristolochic acid in botanicals and dietary supplements by liquid chromatography with ultraviolet detection and by liquid chromatography/mass spectrometry: single laboratory validation confirmation显示文摘 | WILLIAM A Trujillo WENDY R Sorenson PAUL La Luzerne | 2006 | Journal of AOAC International2006，89，4： | 1 |
| 7 | Risk stratification of upper GI bleeding with an esophageal capsule显示文摘 | Sujievvan Chandran Adam Testro Paul Urquhart Richard La Nauze Sim Ong Edward Shelton Hamish Philpott Siddarth Sood Rhys Vaughan William Kemp Gregor Brown Paul Froomes | 2013 | Gastrointestinal Endoscopy2013，，6： | 1 |
| 8 | Executive Insights: Exporting services to Southeast Asia: lessons from Australian knowledge-based service exporters 显示文摘 | Chris Styles Paul G Patterson Vinh Q La | 2005 | Journal of International Marketing2005，13，4： | 1 |
| 9 | The soluble transferrin receptor in dysplastic erythropoiesis in myelodysplastie syndrome显示文摘 | Georgia Metzgeroth Paul La Rose'e Christian Kuhn | 2007 | 79: 8 - 162007，79，： | 1 |
| 10 | Production of a healthy calf by somatic cell nuclear transfer without micromanipulators and carbon dioxide incubators using the Handmade Cloning (HMC) and the Submarine Incubation System (SIS)显示文摘 | Gábor Vajta Paul Bartels Jennifer Joubert Morné de la Rey Robert Treadwell Henrik Callesen | 2004 | Theriogenology2004，，8： | 1 |
| 11 | Schmorl’s nodes显示文摘 | Kwaku A. Kyere Khoi D. Than Anthony C. Wang Shayan U. Rahman Juan M. Valdivia–Valdivia Frank La Marca Paul Park | 2012 | European Spine Journal2012，，： | 1 |
| 12 | Cox-2 expression, PGE 2 and cytokines production are inhibited by endogenously synthesized n -3 PUFAs in inflamed colon of fat-1 mice显示文摘 | Claudia Gravaghi Krista M.D. La Perle Paul Ogrodwski Jing X. Kang Fred Quimby Martin Lipkin Sergio A. Lamprecht | 2011 | The Journal of Nutritional Biochemistry2011，，4： | 1 |
| 13 | Compa-rison of plasma-catalyst and lean NOx catalyst for diesel NOx reduction显示文摘 | John Hoard Paul Laing Lou Balmer M | 2000 | SAE Paper2000，，： | 1 |
| 14 | Revealing CO_(2)-Fixing SAR11 Bacteria in the Ocean by Raman-Based Single-Cell Metabolic Profiling and Genomics显示文摘The majority of marine microbes remain uncultured,which hinders the identification and mining of CO_(2)-fixing genes,pathways,and chassis from the oceans.Here,we investigated CO_(2)-fixing microbes in seawater from the euphotic zone of the Yellow Sea of China by detecting and tracking their ^(13)C-bicarbonate(^(13)C-HCO_(3)^(-))intake via single-cell Raman spectra(SCRS)analysis.The target cells were then isolated by Raman-activated Gravity-driven Encapsulation(RAGE),and their genomes were amplified and sequenced at one-cell resolution.The single-cell metabolism,phenotype and genome are consistent.We identified a notyet-cultured Pelagibacter spp.,which actively assimilates ^(13)C-HCO_(3)^(-),and also possesses most of the genes encoding enzymes of the Calvin-Benson cycle for CO_(2) fixation,a complete gene set for a rhodopsin-based light-harvesting system,and the full genes necessary for carotenoid synthesis.The four proteorhodopsin(PR)genes identified in the Pelagibacter spp.were confirmed by heterologous expression in E.coli.These results suggest that hitherto uncultured Pelagibacter spp.uses light-powered metabolism to contribute to global carbon cycling. | Xiaoyan Jing Yanhai Gong Teng Xu Paul ADavison Craig MacGregor-Chatwin CNeil Hunter La Xu Yu Meng Yuetong Ji Bo Ma Jian Xu Wei E.Huang | 2022 | BioDesign Research2022，，1： | 1 |
| 15 | Suppression of polygalacturonase gene expression in the phytopathogenic fungus Ophiostoma novo-ulmi by RNA interference显示文摘 | Joyce S. Carneiro Paul Y. de la Bastide Meghan Chabot Lindsey Lerch William E. Hintz | 2010 | Fungal Genetics and Biology2010，，5： | 1 |
| 16 | Relationship of physical and functional independence and perceived quality of life of veteran patients with Alzheimer disease显示文摘 | Paul AY Dong YK Jeffrey LA | 2013 | American Journal of Hospice and Palliative Medicine2013，30，5： | 1 |
| 17 | A systems approach to preoperative surgical patie - nt skin preparation 显示文摘 | Seal LA Paul - Cheadle D | 2004 | Am J Infect Control2004，32，2： | 1 |
| 18 | Microtubule Reduction in Alzheimer’s Disease and Aging Is Independent of τ Filament Formation显示文摘 | Adam D. Cash Gjumrakch Aliev Sandra L. Siedlak Akihiko Nunomura Hisashi Fujioka Xiongwei Zhu Arun K. Raina Harry V. Vinters Massimo Tabaton Anne B. Johnson Manuel Paula-Barbosa Jesus Avíla Paul K. Jones Rudy J. Castellani Mark A. Smith George Perry | 2003 | The American Journal of Pathology2003，，5： | 1 |
| 19 | Assembly and Magnetic Bistability of Mn<sub>3</sub>O<sub>4</sub> Nanoparticles Encapsulated in Hollow Carbon Nanofibers显示文摘 | Maria del Carmen Gimenez‐Lopez Alessandro La Torre Michael W. Fay Paul D. Brown Andrei N. Khlobystov | 2013 | Angew Chem Int Ed2013，，7： | 1 |
| 20 | Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis显示文摘 | Ian R van Driel Alan G Baxter Karen L Laurie Tricia D Zwar Nicole L La Gruta Louise M Judd Katrina L Scarff Pablo A Silveira Paul A Gleeson | 2002 | Autoimmunity Reviews2002，，5： | 1 |
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