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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 3 | Morbidity and mortality during the first two years of life among uninfected children born to human immunodeficiency virus type 1-infected women: the women and infants transmission study显示文摘 | Paul ME Chantry CJ Read JS | 2005 | Pediatr Infect Dis J2005，24，1： | 1 |
| 4 | Leg and trunk length at 43 years in relation to childhood health, diet and family circu- mstances ;evidence from the1946 national birth cohort 显示文摘 | Wadsworth ME Hardy RJ Paul AA | 2002 | Int J Epidemiol2002，31，2： | 1 |
| 5 | Salmonella carrier state in chicken: comparison of expression of immune response genes between susceptible and resistant animals显示文摘 | Jean-Rémy Sadeyen Jér?me Trotereau Philippe Velge José Marly Catherine Beaumont Paul A. Barrow Nat Bumstead Anne-Christine Lalmanach | 2004 | Microbes and Infection2004，，14： | 1 |
| 6 | Acoustic radiation force impulse: a new ultrasonographic technology for the widespread noninvasive diagnosis of liver fibrosis显示文摘 | Jér?me Boursier Gael Isselin Isabelle Fouchard-Hubert Frédéric Oberti Nina Dib Jér?me Lebigot Sandrine Bertrais Yves Gallois Paul Calès Christophe Aubé | 2010 | European Journal of Gastroenterology & Hepatology2010，，9： | 1 |
| 7 | Beyond the stuco tower:design,development,and dissemination of the SPARK physical education programs显示文摘 | Me Kenzie L James F Sallis Paul Rosengard | 2009 | Quest2009，61，： | 1 |
| 8 | Microbubble Ultrasound Constrast in the Assessment of Hepatic Artery Patency Following Liver Transplantation:Role in Reducing Frequency of Hepatic Artery Arteriography显示文摘 | Paul SS Ashley SS Stephen ME | 2004 | Eur Radiol2004，14，1： | 1 |
| 9 | Results for a series of 697 AVMs treated by gamma knife : influence of angiographic features on the obliteration rate 显示文摘 | Paul L Casasco A Kusak ME | 2014 | Neurosurgery2014，75，5： | 1 |
| 10 | Comparison of CD8+ T cell subsets in HIV infected rapid progressor children versus non - rapid progressor children显示文摘 | Paul ME Shearer WT Kozinetz CA | 2001 | J Allergy Clin Immunol2001，108，2： | 1 |
| 11 | Risk factors for in utero and intrapartum transmission of HIV显示文摘 | Magder LS Mofenson L Paul ME | 2005 | J Acquir Immune Defic Syndr2005，38，1： | 1 |
| 12 | Man-in-the-Barrel syndrome in a nncomatose patient:a case report显示文摘 | Paul GO maury RE Lawrence ME | 1991 | Arch Phy Med rehabll1991，72，： | 1 |
| 13 | Risk factors of in utero and intrapartum transmission of HIV显示文摘 | Magder LS Mofenson L Paul ME | 2005 | J Acquir Immune Defic Syndr2005，38，1： | 1 |
| 14 | Endoscopic ultrasound guided fine-needle aspiration and 18FDG-positron emission tomography in the evaluation of patients with non-small cell lung cancer显示文摘 | CRAANEN ME COMANS EF PAUL MA | 2007 | Interact Cardiovasc Thorac Surg2007，6，4： | 1 |
| 15 | Chest trauma-current morbidity and mortality显示文摘 | Dougall AM Paul ME Finley RT | | 0，，07： | 1 |
| 16 | Is having polycystic ovary syndrome a predictor of poor psycho- logical function including anxiety and depression 显示文摘 | DeeksAA Gibson-Helm ME Paul E eta1 | 2011 | Hum Reprod2011，26，6： | 1 |
| 17 | MRI characteristics of neuromyelitis optica spectrum disorder: An international update显示文摘 | Ho Jin Kim Friedemann Paul Marco A. Lana-Peixoto Silvia Tenembaum Nasrin Asgari Jacqueline Palace Eric C. Klawiter Douglas K. Sato Jér?me de Seze Jens Wuerfel Brenda L. Banwell Pablo Villoslada Albert Saiz Kazuo Fujihara Su-Hyun Kim | 2015 | Neurology2015，，11： | 1 |
| 18 | Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive显示文摘 | Jér?me Boursier Victor de Ledinghen Jean‐Pierre Zarski Isabelle Fouchard‐Hubert Yves Gallois Frédéric Oberti Paul Calès | 2011 | Hepatology2011，，1： | 1 |
| 19 | Comparison of CD8 (+) T-cell subsets in HIV-irffected rapid progressor children versus non-rapid progressor children显示文摘 | Paul ME Shearer WT Kozinetz CA | 2001 | J Al- lergy Clin Immunol2001，108，2： | 1 |
| 20 | ls having polycystic o- vary syndrome a predictor of poor psychological function including anxiety and depression显示文摘 | Deeks AA Gibson - Helm ME Paul E | 2011 | Hum Repred2011，6，： | 1 |
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