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| 1 | Genotypes and viral variants in chronic hepatitis B: A review of epidemiology and clinical relevance显示文摘The Hepatitis B Virus(HBV) has a worldwide distribu-tion and is endemic in many populations. It is constantly evolving and 10 genotypic strains have been identified with varying prevalences in different geographic regions. Numerous stable mutations in the core gene and in the su-rface gene of the HBV have also been identified in untreated HBV populations. The genotypes and viral variants have been associated with certain clinical featu-res of HBV related liver disease and Hepatocellu-lar carcinoma. For example Genotype C is associated withlater hepatitis B e antigen(HBe Ag) seroconversion, and more advanced liver disease. Genotype A is associated with a greater risk of progression to chronicity in adu-lt acqu-ired HBV infections. Genotype D is particu-larly associated with the precore mu-tation and HBe Ag negative chronic hepatitis B(CHB). The genotypes prevalent in parts of West Africa, Central and Sou-th America, E, F and H respectively, are less well stu-died. Viral variants especially the Basal Core Promotor mutation is associated with increased risk of fibrosis and cancer of the liver. Althou-gh not cu-rrently part of rou-tine clinical care, evalu-ation of genotype and viral variants may provide u-sefu-l adju-nctive information in predicting risk abou-t liver related morbidity in patients with CHB. | Catherine MN Croagh Paul V Desmond Sally J Bell | 2015 | World Journal of Hepatology2015，7，3： | 24 |
| 2 | Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of pa- tients with advanced breast cancer: a phase 11, randomized, open-label trial 显示文摘 | Robert NJ Saleh MN Paul D | 2011 | Clin Breast Cancer2011，11，2： | 1 |
| 3 | Sunitinib plus pacli- taxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: a phase IlI, randomized, open-label trial显示文摘 | Robert NJ Saleh MN Paul D | 2011 | Clin Breast Cancer2011，11，2： | 1 |
| 4 | A- bility of MBP or RBP signal peptides to influence folding and in vitro translocation of wild-type and hybrid precursors显示文摘 | ROSEMOND J C SHARON MN M S PAUL H R | 1994 | FEBS Letters1994，349，2： | 1 |
| 5 | A study on interferon-gamma(IFN-gamma)response by Tcells stimulated by hepatitis B virus core antigen显示文摘 | Paul S Tabassum S Islam MN | 2004 | Bangladesh Med Res Counc Bull2004，30，： | 1 |
| 6 | Interferon-gamma (IFN-gamma) response to different hepatitis B virus antigens in hepatitis B virus infection 显示文摘 | Paul S Tabassum S Islam MN | 2004 | Bangladesh Med Res Counc Bull2004，30，2： | 1 |
| 7 | Review of facilitated approaches to vascular anastomosis surgery显示文摘 | Paul MN Werker Moshe K | 1997 | Ann Thorac Surg1997，63，： | 1 |
| 8 | Long-term results of local excision for rectal cancer显示文摘 | Philip BP Garrett MN Paul B | 2002 | Ann Surg2002，236，4： | 1 |
| 9 | Sunitinib plus paclitaxel ver- sus bevaeizumab plus paclitaxel for first - line treatment of pa- tients with advanced breast cancer: a phase III, randomized, open -label trial显示文摘 | Robert N J Saleh MN Paul D | 2010 | Cancer2010，136，18： | 1 |
| 10 | PET and SPECT imaging in psychiatry disorders显示文摘 | Robert Z Jeffrey MN Paul V | 2007 | Can J Psychiatry2007，52，3： | 1 |
| 11 | Approach and considerations regarding the patient with spinal injury显示文摘 | Paul LC Adrian MN | 2005 | Care Injured2005，36，1： | 1 |
| 12 | Upper tract tumour after radical cystectomy for transitional cell carcinoma of the bladder:incidence and risk factors显示文摘 | Paul DS Pablo G Alan MN | 2004 | BJU Int2004，94，6： | 1 |
| 13 | Synergistic proinflammatory re- sponses induced by polymicrobial colonization of epithelial surfaces 显示文摘 | Ratner AJ' Lysenko ES Paul MN | 2005 | Proc Natl Acad Sci USA2005，102，9： | 1 |
| 14 | Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: a phase Ill , randomized, open-label trial显示文摘 | Robert NJ Saleh MN Paul D | 2011 | Clin Breast Cancer2011，11，2： | 1 |
| 15 | Sunitinib plus paclitaxelversus bevacizumab plus paclitaxel for first-line treatment ofpatients with advancedbreast cancer: a phase IH,randomized,open-label trial 显示文摘 | Robert NJ Saleh MN Paul D | 2011 | Clin Breast Cancer2011，11，2： | 1 |
| 16 | Interferon-gamma (IFN-gamma) response to different hepatitis B virusantigens in hepatitis B virus infection显示文摘 | Paul S Tabassum S Islam MN | 2004 | Bangladesh Med Res Counc Bull2004，30，： | 1 |
| 17 | Sunitinib plus paclitaxel versus be- vacizumab plus paelitaxel for first-line treatment of patients with advanced breast cancer:a phase HI ,randomized,open-label trial 显示文摘 | Robert NJ Saleh MN Paul D | 2011 | Clin Breast Cancer2011，11，2： | 1 |
| 18 | Soy protein containing isoflavones does not decrease colorectal epithelial cell proliferation in a randomized controlled triall 显示文摘 | Kenneth FA Paul DL Katherine MN | 2005 | America Journal Chnic Nutrition2005，82，： | 1 |
| 19 | Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced b~ast cancer : a phase III, randomized, open-label trial显示文摘 | Robert NJ Saleh MN Paul D | 2011 | Clin Breast Cancer2011，11，2： | 1 |
| 20 | Long-term results of local excision for rectal cancer显示文摘 | Philip BP Garrett MN Paul B | 2002 | Ann Surg2002，236，4： | 1 |
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