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| 1 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 2 | A rapid physical-chemical method for the determination of readily biodegradable soluble COD in municipal wastewater显示文摘 | Paul Pitt | 1993 | Wat Res1993，27，1： | 1 |
| 3 | A rapid physical-chemical method for the determination of readily biodegradable soluble COD in municipal wastewater显示文摘 | David Jenkins Paul Pitt | 1993 | Wat Res1993，27，1： | 1 |
| 4 | Recombinant C fragment of botulinum neurotoxin B serotype (rBoNTB (H C )) immune response and protection in the rhesus monkey显示文摘 | James Boles Michael West Vicki Montgomery Ralph Tammariello M. Louise M. Pitt Paul Gibbs Leonard Smith Ross D. LeClaire | 2006 | Toxicon2006，，8： | 1 |
| 5 | Generation of protective immunity by inactivated recombinant staphylococcal enterotoxin B vaccine in nonhuman primates and identification of correlates of immunity显示文摘 | James W Boles M.Louise M. Pitt Ross D LeClaire Paul H Gibbs Edna Torres Beverly Dyas Robert G Ulrich Sina Bavari | 2003 | Clinical Immunology2003，，1： | 1 |
| 6 | The Seattle Heart Failure Model: Prediction of Survival in Heart Failure显示文摘 | Wayne C. Levy Dariush Mozaffarian David T. Linker Santosh C. Sutradhar Stefan D. Anker Anne B. Cropp Inder Anand Aldo Maggioni Paul Burton Mark D. Sullivan Bertram Pitt Philip A. Poole-Wilson Douglas L. Mann Milton Packer | 2006 | Circulation2006，，11： | 1 |
| 7 | Angiotensin II receptor antagonists in heart failure: Rationale and design of the evaluation of losartan in the elderly (ELITE) trial显示文摘 | Bertram Pitt MD Paul Chang Pieter B. M. WW. M. Timmermans | 1995 | Cardiovascular Drugs and Therapy1995，，5： | 1 |
| 8 | Impact of guideline adherence and race on asthma control in children显示文摘Background Asthma control in African Americans(AA)is considered more difficult to achieve than in Caucasian Americans(CA).The aim of this study was to compare asthma control over time among AA and CA children w hose asthma is managed per NAEPP(EPR-3)guidelines.Methods This was a one-year prospective study of children referred by their primary care physicians for better asthma care in a specialty asthma clinic.All children received asthma care per NAEPP guidelines.Results were compared between CA and AA children at baseline and then at three-month intervals for one year.Results Of the 345 children,ages 2-17 years(mean=6.2±4),220(63.8%)were CA and 125(36.2%)were AA.There were no significant differences in demographics other than greater pet ownership in CA families.At baseline,AA children had significantly more visits to the Emergency Department for acute asthma symptoms(mean=2.3±3)compared to CA(1.4±23,P=0.003).There were no other significant differences in acute care utilization,asthma symptoms(mean days/month),or mean asthma control test(ACT)scores at base line.Within 3-6 months,in both groups,mean ACT scores,asthma symptoms and acute care utilization significantly improved(P<0.05 for all)and change over time in both groups was comparable except for a significantly greater decrease in ED visits in AA children compared to CA children(P=002).Conclusion Overall,improvement in asthma control during longitudinal assessment was similar between AA and CA children because of consistent use of NAEPP asthma care guidelines. | Shahid I.Sheikh Nancy A.Ryan-Wenger Judy Pitts Rodney Britt Jr Grace Paul Lisa Ulrich | 2021 | World Journal of Pediatrics2021，17，5： | 0 |
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