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| 1 | Family and twin studies in inflammatory bowel disease显示文摘在不同家庭组以内检验煽动性的肠疾病(IBD ) 的继承的研究是在 IBD 的遗传的最近的分子的进展的基础。在 Crohn 的疾病(CD ) 的导出的可遗传性比在许多另外的复杂疾病高。IBD 的风险在受不了 ulcerative (UC ) 的一个职业人员乐队的一个 CD 职业人员乐队,而是一度的亲戚的一度的亲戚是最高的,更远的亲戚也在增加的风险。在 IBD 的疾病词语索引率在复合家庭并且在三大欧洲成双的研究被检验了。 | Leena Halme Paulina Paavola-Sakki Ulla Turunen Maarit Lappalainen Martti Frkkil Kimmo Kontula | 2006 | World Journal of Gastroenterology2006，12，23： | 8 |
| 2 | 滇池中溶藻细菌的分离鉴定及其溶藻效应显示文摘【背景】藻类水华或赤潮在世界范围内频发,带来各种危害,亟需找到有效途径控制水华或赤潮。溶藻细菌具有杀死藻类控制藻类生物量的能力,可以作为防治水华和赤潮的有效工具。【目的】分离并鉴定滇池中的铜绿微囊藻(Microcystisaeruginosa)及其溶藻细菌,对溶藻菌作用于铜绿微囊藻的溶藻效应进行研究,初步了解其溶藻特性与溶藻机制。【方法】采用LB平板稀释涂布,再经多次划线分离纯化细菌,测定16SrRNA基因序列以鉴定细菌种类;采用毛细管分离的方法分离铜绿微囊藻,并测定其cpcBA基因序列以鉴定蓝藻种类;采用热乙醇法提取叶绿素a,从而计算溶藻效率;基于过氧化氢酶(CAT)、还原型谷胱甘肽(GSH)和丙二醛(MDA)探究藻细胞在溶藻菌处理下的抗氧化系统响应。【结果】共分离获得11株微囊藻和17株针对铜绿微囊藻的高效溶藻菌。选取其中一株生长速度最快的铜绿微囊藻DCM4和一株溶藻效果最好的溶藻菌Sp37 (Bacillus siamensis)进行后续研究。Sp37对DCM4的4 d溶藻率达到92.4%±1.5%,且对微囊藻属的水华微囊藻(M. flos-aquae)和惠氏微囊藻(M.wesenbergii)均有溶藻效果,而对绿藻没有溶藻效果。Sp37的原菌液和无菌滤液对DCM4的4d溶藻率分别为86.8%±4.3%和81.1%±2.2%,两者没有显著差异(P>0.05)。Sp37菌体对DCM4的溶藻率为25.4%±7.3%。Sp37无菌滤液经不同温度和pH处理之后的溶藻率与未经处理的无菌滤液的溶藻率无明显差异。Sp37无菌滤液处理藻细胞会使藻细胞的CAT、GSH和MDA含量发生变化。【结论】菌株Sp37对铜绿微囊藻DCM4具有高效的溶藻作用,而且对微囊藻属具有一定的溶藻特异性。Sp37是通过分泌胞外物质间接溶藻,且溶藻物质具有热稳定性和酸碱稳定性。Sp37无菌滤液处理藻细胞会触发藻细胞抗氧化系统,并且会损伤藻细胞膜。Sp37无菌滤液很可能是通过对藻细胞造成氧化胁迫,最终导致藻细胞死亡的。 | 王琪 Paulina Simon 刘锦钰 迟玉新 代先祝 杜红霞 张晓辉 五十岚泰夫 杨彩云 罗锋 | 2018 | 微生物学通报2018，45，12： | 8 |
| 3 | Comprehensive Approach for Porous Materials Analysis Using a Dedicated Preprocessing Tool for Mass and Heat Transfer Modeling显示文摘The paper presents a comprehensive, newly developed software – poROSE(poROus materials examination SoftwarE) for the qualitative and quantitative assessment of porous materials and analysis methodologies developed by the authors as a solution for emerging challenges. A low porosity rock sample was analyzed and thanks to the developed and implemented methodologies in poROSE software, the main geometrical properties were calculated. A tool was also used in preprocessing part of the computational analysis to prepare a geometrical representation of the porous material. The basic functions as elimination of blind pores in the geometrical model were completed and the geometrical model was exported for CFD software. As a result, it was possible to carry out calculations of the basic properties of the analyzed porous material sample. The developed tool allows to carry out quantitative and qualitative analysis to determine the most important properties characterized porous materials. In presented tool the input data can be images from X-ray computed tomography(CT), scanning electron microscope(SEM) or focused ion beam with scanning electron microscope(FIB-SEM) in grey level. A geometric model developed in the proper format can be used as an input to modeling mass, momentum and heat transfer, as well as, in strength or thermo-strength analysis of any porous materials. In this example, thermal analysis was carried out on the skeleton of rock sample. Moreover, thermal conductivity was estimated using empirical equations. | MADEJSKI Pawel KRAKOWSKA Paulina HABRAT Magdalena PUSKARCZYK Edyta JEDRYCHOWSKI Mariusz | 2018 | Journal of Thermal Science2018，27，5： | 7 |
| 4 | Helicobacter Pylori Infection and Lung Cancer: New Insights and Future Challenges显示文摘Helicobacter pylori(H. pylori) is the causative agent of chronic gastritis and peptic ulcer diseases and is an important risk factor for the development functional dyspepsia, peptic ulceration, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. H. pylori has very high rates of infection in human populations, and it is estimated that over 50% of the world population is infected. Recently, certain extra-gastric manifestations, linked to H. pylori infection, have been widely investigated. Noteworthy, a growing body of evidences supports an association between H. pylori infection with lung cancer. The present review intend to highlight not only the most recent evidences supporting this association, but also some missed points, which must be considered to validate this emerging association. | Ileana GONZALEZ Paulina ARAYA Armando ROJAS | 2018 | 中国肺癌杂志2018，21，9： | 7 |
| 5 | 改进的石墨烯基材料用作菜籽油转酯化反应制生物柴油的有效催化剂(英文)显示文摘本文研究了不同石墨烯基材料用作转酯化反应制备生物柴油催化剂的性能.将磺酸基或磷酸盐基嫁接到热还原的氧化石墨烯表面,制备了固体酸石墨烯基样品.并采用扫描电镜、X射线衍射、热重分析、X射线光电子能谱、N2吸附-脱附法、电位滴定法、元素分析以及红外光谱法对所制样品进行了全面表征.将所制样品用于130 oC带压力的条件下菜籽油与甲醇转酯化反应中,并将其催化活性与商用的多相酸催化剂Amberlyst-15的进行了比较.结果表明,所有改进的样品在转酯化反应中均表现出催化活性,但各样品上生物柴油产率差别较大.其中以苯二氮磺酸基功能化的热还原氧化石墨烯样品上脂肪酸甲酯产率最高,反应6 h后达70%,也明显高于商用催化剂Amberlyst-15.该样品也表现出良好的重复使用性能. | Justina Gaidukevic Jurgis Barkauskas Anna Malaika Paulina Rechnia-Goracy Aleksandra Mozdzynska Vitalija Jasulaitiene Mieczyslaw Kozlowski | 2018 | Chinese Journal of Catalysis2018，39，10： | 6 |
| 6 | Ethanolic extracts of babandotan leaves(Ageratum conyzoides L.)prevents inflammation and proteoglycan degradation by inhibiting TNF-αand MMP-9 on osteoarthritis rats induced by monosodium iodoacetate显示文摘Objective:To analyze the effects of Ageratum conyzoides L.on the monosodium iodoacetate induced osteoarthritis rats.Methods:Thin layer chromatography was performed to analyze the constituents of the babandotan extract leaves.White male Sprague-Dawley rats used in this study were divided into 6 groups:normal control and negative control groups,both given0.5%carboxymethyl cellulose;the positive control group that was given glucosamine and chondroitin suspension(486 mg/200 g B.W.);the 3 dose variation extract groups including dose 1,2,and 3 that were given 40,80,and 160 mg/200 g B.W.respectively on day 29 until50.All the groups were induced with 0.05 mL monosodium iodoacetate(20 mg/mL)on day1,except normal control induced by saline.Measurement of edema volume of rat knees was performed on day 0,8,15,22,29,43,and 50.Hematology data was measured at day 1,29and 50.Serum was collected at day 50 to evaluate TNF-α and MMP-9 by ELISA.Cartilage histopathology was evaluated by staining with H&E and Safranin-o-fast green staining on day 50.Results:The babandotan leaves extract dose 2(80 mg/200 g B.W.)and dose 3(160mg/200 g B.W.)could decrease the edema volume,increase the area and thickness of articular cartilage,and increase proteoglycan level.Particularly,dose 3(160 mg/200 g B.W.)of extract babandotan leaves were able to significantly decrease the number of leukocytes,lymphocytes and udem volume,and decrease TNF alpha and MMP-9 levels.Conclusions:Babandotan leaves extract can recover inflammation and cartilages degradation by inhibiting TNF-αin inflammation processes and MMP-9 in the collagenase reaction in the cartilages. | Anton Bahtiar Mutiara Nurazizah Tirza Roselina Anita Paulina Tambunan Ade Arsianti | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，3： | 6 |
| 7 | H2O2诱导ARPE-19细胞损伤模型的建立及蓝莓花青素的保护作用显示文摘目的建立H_2O_2诱导视网膜色素上皮细胞ARPE^(-1)9(acute retinal pigment epithelial^(-1)9)细胞损伤模型,研究蓝莓花青素对细胞的保护作用。方法采用MTT法测定细胞存活率,免疫荧光法测定细胞活性氧(reactive oxygen species,ROS)水平。以浓度0~3 200μmol·L^(-1)的H_2O_2为诱导剂,刺激细胞2、6、24 h,用1、5、10 mg·L^(-1)花青素提取物(blueberry anthocyanin extract,BAE)预处理细胞6、24 h,比较对细胞的保护作用,确定H_2O_2的浓度及诱导时间。通过ARPE^(-1)9细胞损伤模型的建立,研究蓝莓花青素对细胞的保护作用。结果以800μmol·L^(-1)H_2O_2刺激2 h为条件,建立ARPE^(-1)9细胞损伤模型,细胞存活率为63.69%。5 mg·L^(-1)蓝莓花青素提取物、锦葵色素(malvidin,Mv)及其葡萄糖苷(malvidin-3-glucoside,Mv-3-glc)和半乳糖苷(malvidin-3-galactoside,Mv-3-gal)预处理6 h后,细胞存活率明显提高(P<0.01),分别达到86.57%、115.72%、98.15%、127.97%;细胞中ROS水平明显下降(P<0.05),依次减少52.38%、95.38%、77.55%、116.09%。结论蓝莓花青素可以有效抑制H_2O_2诱导产生的视网膜细胞氧化损伤,其中主成分锦葵色素及其糖苷发挥重要作用。 | 吴寒 HUTABARAT Ruth Paulina 黄午阳 | 2018 | 中国药理学通报2018，34，2： | 5 |
| 8 | Nutritional therapy for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most frequent primary liver cancer and presents together with cirrhosis in most cases.In addition to commonly recognized risk factors for HCC development,such as hepatitis B virus/hepatitis C virus infection,age and alcohol/tobacco consumption,there are nutritional risk factors also related to HCC development including high intake of saturated fats derived from red meat,type of cooking(generation of heterocyclic amines)and contamination of foods with aflatoxins.On the contrary,protective nutritional factors include diets rich in fiber,fruits and vegetables,n-3 polyunsaturated fatty acids and coffee.While the patient is being evaluated for staging and treatment of HCC,special attention should be paid to nutritional support,including proper nutritional assessment and therapy by a multidisciplinary team.It must be considered that these patients usually develop HCC on top of long-lasting cirrhosis,and therefore they could present with severe malnutrition.Cirrhosisrelated complications should be properly addressed and considered for nutritional care.In addition to traditional methods,functional testing,phase angle and computed tomography scan derived skeletal muscle index-L3 are among the most useful tools for nutritional assessment.Nutritional therapy should be centered on providing enough energy and protein to manage the increased requirements of both cirrhosis and cancer.Supplementation with branched-chain amino acids is also recommended as it improves response to treatment,nutritional status and survival,and finally physical exercise must be encouraged and adapted to individual needs. | Astrid Ruiz-Margáin Berenice M Román-Calleja Paulina Moreno-Guillén JoséA González-Regueiro DeyaniraKúsulas-Delint Alejandro Campos-Murguía Nayelli C Flores-García Ricardo Ulises Macías-Rodríguez | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 4 |
| 9 | Impact of Helicobacter pylori on the healing process of the gastric barrier显示文摘AIM To determine the impact of selected well defined Helicobacter pylori(H. pylori) antigens on gastric barrier cell turnover.METHODS In this study,using two cellular models of gastric epithelial cells and fibroblasts,we have focused on exploring the effects of well defined H. pylori soluble components such as glycine acid extract antigenic complex(GE),subunit A of urease(Ure A),cytotoxin associated gene A protein(Cag A) and lipopolysaccharide(LPS) on cell turnover by comparing the wound healing capacity of the cells in terms of their proliferative and metabolic activity as well as cell cycle distribution. Toxic effects of H. pylori components have been assessed in an association with damage to cell nuclei and inhibition of signal transducer and activator of transcription 3(STAT3) phosphorylation. RESULTS We showed that H. pylori GE,Cag A and Ure A promoted regeneration of epithelial cells and fibroblasts,which is necessary for effective tissue healing. However,in vivo increased proliferative activity of these cells may constitute an increased risk of gastric neoplasia. In contrast,H. pylori LPS showed a dose-dependent influence on the process of wound healing. At a low concentration(1 ng/m L) H. pylori LPS accelerated of healing epithelial cells,which was linked to significantly enhanced cell proliferation and MTT reduction as well as lack of alterations in cell cycle and downregulation of epidermal growth factor(EGF) production as well as cell nuclei destruction. By comparison,H. pylori LPS at a high concentration(25 ng/m L) inhibited the process of wound repair,which was related to diminished proliferative activity of the cells,cell cycle arrest,destruction of cell nuclei and downregulation of the EGF/STAT3 signalling pathway.CONCLUSION In vivo H. pylori LPS driven effects might lead to the maintenance of chronic inflammatory response and pathological disorders on the level of the gastric mucosal barrier. | Eliza Mnich Magdalena Kowalewicz-Kulbat Paulina Sicińska Krzysztof Hinc Michal Obuchowski Adrian Gajewski Anthony P Moran Magdalena Chmiela | 2016 | World Journal of Gastroenterology2016，22，33： | 4 |
| 10 | Plant Growth-Promoting Traits in Rhizobacteria of Heavy Metal-Resistant Plants and Their Effects on Brassica nigra Seed Germination显示文摘Phytoremediation is an emerging technology that uses plants and their associated microbes to clean up pollutants from the soil, water, and air. In order to select the plant growth-promoting rhizobacteria(PGPR) for phytoremediation of heavy metal contamination, 60 bacterial strains were isolated from the rhizosphere of two endemic plants, Prosopis laevigata and Spharealcea angustifolia, in a heavy metal-contaminated zone in Mexico. These rhizobacterial strains were characterized for the growth at different pH and salinity, extracellular enzyme production, solubilization of phosphate, heavy metal resistance, and plant growth-promoting(PGP) traits, including production of siderophores and indol-3-acetic acid(IAA). Overall, the obtained rhizobacteria presented multiple PGP traits. These rhizobacteria were also resistant to high levels of heavy metals(including As as a metalloid)(up to 480 mmol L(-1)As(V), 24 mmol L(-1)Pb(Ⅱ), 21 mmol L(-1)Cu(Ⅱ), and 4.5 mmol L(-1)Zn(Ⅱ)). Seven rhizobacterial strains with the best PGP traits were identified as members of Alcaligenes, Bacillus, Curtobacterium, and Microbacterium, and were selected for further bioassay.The inoculation of Brassica nigra seeds with Microbacterium sp. CE3R2, Microbacterium sp. NE1R5, Curtobacterium sp. NM1R1,and Microbacterium sp. NM3E9 facilitated the root development; they significantly improved the B. nigra seed germination and root growth in the presence of heavy metals such as 2.2 mmol L(-1)Zn(Ⅱ). The rhizobacterial strains isolated in the present study had the potential to be used as efficient bioinoculants in phytorremediation of soils contaminated with multiple heavy metals. | Brenda ROMN-PONCE Diana Miryel REZA-VZQUEZ Sonia GUTIRREZ-PAREDES María de Jesús DE HARO-CRUZ Jessica MALDONADO-HERNNDEZ Yanely BAHENA-OSORIO Paulina ESTRADA-DE LOS SANTOS En Tao WANG María Soledad VSQUEZ-MURRIETA | 2017 | Pedosphere2017，27，3： | 4 |
| 11 | 脐带间充质干细胞在细胞治疗中的应用潜能显示文摘人脐带间充质干细胞是近年人们从胎儿脐带华尔通氏胶部位分离得到的基质细胞,具有一定干细胞特性,已证实有多向分化潜能和可塑性。脐带间充质干细胞来源丰富,培养方法简单,增殖能力旺盛,排异反应低,无伦理道德争议,可望成为自体与同种异体移植及细胞替代治疗的理想细胞来源。 | 褚晓倩 王丽 Paulina Duya 边育红 | 2012 | 长春中医药大学学报2012，28，3： | 3 |
| 12 | 中药天然产物为γδT细胞肿瘤免疫治疗提供了新思路显示文摘γδT细胞作为一群性质独特的固有免疫细胞,γδT细胞在肿瘤免疫中的作用受到越来越多关注。研究发现,γδT细胞在肿瘤免疫中发挥促瘤和抑瘤双向作用,γδT细胞抗肿瘤治疗应用于临床取得了令人鼓舞的进步,尤其是近年来研究人员提出γδT细胞外泌体和CAR-γδT细胞过继免疫治疗等新思路。然而γδT细胞扩增率不高、靶向性不强、肿瘤微环境限制γδT治疗效果等问题亟待突破,天然药物有望在改善机体免疫状态、促进γδT细胞的增殖活化及诱导γδT细胞分化等方面起到的积极作用。本文总结γδT在肿瘤免疫治疗方面的研究进展和亟待解决的问题,并提出天然药物为γδT细胞肿瘤免疫治疗提供新思路。 | Paulina Atieno Duya 陈银潇 白立鼎 李兆栋 李佳颖 柴润东 边育红 赵舒武 | 2022 | Acupuncture and Herbal Medicine2022，2，2： | 3 |
| 13 | Outcomes of critically ill cancer patients with Acinetobacter baumannii infection显示文摘AIM: To describe the intensive care unit(ICU) outcomes of critically ill cancer patients with Acinetobacter baumannii(AB) infection.METHODS: This was an observational study that included 23 consecutive cancer patients who acquired AB infections during their stay at ICU of the National Cancer Institute of Mexico(INCan), located in Mexico City. Data collection took place between January 2011, and December 2012. Patients who had AB infections before ICU admission, and infections that occurred during the first 2 d of ICU stay were excluded. Data were obtained by reviewing the electronic health record of each patient. This investigation was approved by the Scientific and Ethics Committees at INCan. Because of its observational nature, informed consent of the patients was not required.RESULTS: Throughout the study period, a total of 494 critically ill patients with cancer were admitted to the ICU of the INCan, 23(4.6%) of whom developed AB infections. Sixteen(60.9%) of these patients had hematologic malignancies. Most frequent reasons for ICU admission were severe sepsis or septic shock(56.2%) and postoperative care(21.7%). The respiratory tract was the most frequent site of AB infection(91.3%). The most common organ dysfunction observed in our group of patients were the respiratory(100%), cardiovascular(100%), hepatic(73.9%) and renal dysfunction(65.2%). The ICU mortality of patients with 3 or less organ system dysfunctions was 11.7%(2/17) compared with 66.6%(4/6) for the group of patients with 4 or more organ system dysfunctions(P = 0.021). Multivariate analysis identified blood lactate levels(BLL) as the only variable independently associated with inICU death(OR = 2.59, 95%CI: 1.04-6.43, P = 0.040). ICU and hospital mortality rates were 26.1% and 43.5%, respectively.CONCLUSION: The mortality rate in critically ill patients with both HM, and AB infections who are admitted to the ICU is high. The variable most associated with increased mortality was a BLL ≥ 2.6 mmol/L in the first day of stay in the ICU. | Silvio A ?amendys-Silva Paulina Correa-García Francisco J García-Guillén María O González-Herrera Américo Pérez-Alonso Julia Texcocano-Becerra Angel Herrera-Gómez Patricia Cornejo-Juárez Abelardo Meneses-García | 2015 | World Journal of Critical Care Medicine2015，4，3： | 3 |
| 14 | Perovskite type lanthanum manganite:Morpho-structural analysis and electrical investigations显示文摘Perovskite-type oxides of LaMnO_3 were synthesized by means of the sol-gel method, in the presence of citric acid as gelling agent. The precursors used were Mn(NO_3)_2·H_2O, La_2O_3, and NaOH,mixed in the stoichiometric ratio to obtain perovskite materials. The obtained gel was heat-treated at 400, 600 and 800 ℃ respectively, for 6 h. X-ray diffraction and FT-IR spectroscopy were used to analyze the phase transformation as a function of temperature, and the Rietveld refinement was used in order to characterize the materials obtained structurally. The average crystallite size of the products was calculated from XRD data and the average particle size was measured from the TEM micrographs. At 600 ℃, the synthesized compound is well-crystallized, showcases a perovskite structure(Pm-3m space group), and exhibits uniform and homogeneous hexagonally-shaped particles, with sizes in the 20-50 nm range.Complex impedance measurements in the 20-2 × 10~6 Hz frequency range were carried out at different temperatures(26-115 ℃), and the electrical conduction mechanism is discussed. | Paula Sfirloaga Maria Poienar Iosif Malaescu Antoanetta Lungu Paulina Vlazan | 2018 | Journal of Rare Earths2018，36，5： | 3 |
| 15 | Bile duct injuries during laparoscopic cholecystectomy: primary and long-term results from a single institution显示文摘 | Jukka Karvonen Risto Gullichsen Simo Laine Paulina Salminen Juha M. Gr?nroos | 2007 | Surgical Endoscopy2007，，7： | 2 |
| 16 | Increased expression of PELP1 in human sperm is correlated with decreased semen quality显示文摘 | Izabela Skibinska Miroslaw Andrusiewicz Michal Soin Magdalena Jendraszak Paulina Urbaniak Piotr Jedrzejczak Malgorzata Kotwicka | 2018 | Asian Journal of Andrology2018，20，5： | 2 |
| 17 | Defective epithelial barrier in chronic rhinosinusitis: The regulation of tight junctions by IFN-γ and IL-4显示文摘 | Michael B. Soyka Paulina Wawrzyniak Thomas Eiwegger David Holzmann Angela Treis Kerstin Wanke Jeannette I. Kast Cezmi A. Akdis | 2012 | The Journal of Allergy and Clinical Immunology2012，，5： | 2 |
| 18 | Endoscopic management of colonic perforations: clips versus suturing closure (with videos)显示文摘 | Sergey V. Kantsevoy Marianne Bitner Gulara Hajiyeva Paulina M. Mirovski Michael E. Cox Thomas Swope Kelly Alexander Nora Meenaghan J. Lawrence Fitzpatrick Vadim Gushchin | 2015 | Gastrointestinal Endoscopy2015，，： | 2 |
| 19 | Biomimetic polymerization of aniline using hematin supported on halloysite nanotubes显示文摘 | TIERRABLANCA Elisa ROMERO-GARC(I)A Jorge ROMAN Paulina | | 0，，1： | 1 |
| 20 | Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer?s disease显示文摘 | Paulina V. Arriagada John H. Growdon E. Tessa Hedley-Whyte Bradley T. Hyman | 1992 | Neurology1992，，3： | 1 |
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