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| 1 | Endoscopic ultrasound elastography strain histograms in the evaluation of patients with pancreatic masses显示文摘AIM: To investigate the accuracy of the strain histogram endoscopic ultrasound(EUS)-based method for the diagnostic differentiation of patients with pancreatic masses. METHODS: In a prospective single center study, 149 patients were analyzed, 105 with pancreatic masses and 44 controls. Elastography images were recorded using commercially available ultrasound equipment in combination with EUS linear probes. Strain histograms(SHs) were calculated by machine integrated software in regions of interest and mean values of the strain histograms were expressed as Mode 1(over the mass) and Mode 2(over an adjacent part of pancreatic tissue, representing the reference area). The ratio between Mode 2 and Mode 1 was calculated later, representing a new variable, the strain histogram ratio. After the final diagnosis was established, two groups of patients were formed: a pancreatic cancer group with positive cytology achieved by fine needle aspiration puncture or histology after surgery(58 patients), and a massforming pancreatitis group with negative cytology and follow-up after 3 and 6 mo(47 patients). All statistical analyses were conducted in SPSS 14.0(SPSS Inc., Chicago, IL, United States).RESULTS: Results were obtained with software for strain histograms with reversed hue scale(0 represents the hardest tissue structure and 255 the softest). Based on the receiver operating characteristics(ROC) curve coordinates, the cut-off point for Mode 1 was set at the value of 86. Values under the cut-off point indicated the presence of pancreatic malignancy. Mode 1 reached 100% sensitivity and 45% specificity with overall accuracy of 66%(95%CI: 61%-66%) in detection of pancreatic malignant tumors among the patients with pancreatic masses. The positive and negative predictive values were 54% and 100%, respectively. The cut-off for the new calculated variable, the SH ratio, was set at the value 1.153 based on the ROC curve coordinates. Values equal or above the cut-off value were indicative of pancreatic malignancy. The SH ratio reached 98% sensitivity, 50% specificity and an overall accuracy of 69%(95%CI: 63%-70%). The positive and negative predictive values were 92% and 100%, respectively.CONCLUSION: SH showed high sensitivity in pancreatic malignant tumor detection but disappointingly low specificity. Slight improvements in specificity and accuracy were achieved using the SH ratio. | Dalibor Opa?i? Nadan Rustemovi? Mirjana Kalauz Pave Marko? Zvonimir Ostoji? Matea Majerovi? Iva Ledinsky Ana Vi?nji? Juraj Krznari? Milorad Opa?i? | 2015 | World Journal of Gastroenterology2015，21，13： | 3 |
| 2 | The role of insulin-like growth factor 2 and its receptors in human tumors显示文摘 | PAVELIC K BUKOVI(C)D PAVELI(C) J | 2002 | Mol Med2002，8，12： | 1 |
| 3 | Processing of yellow pea by germination, microwave treatment and drying显示文摘 | Pave K Alexandra R Andrea H | 2001 | In- novative Food Science and Technologies2001，2，2： | 1 |
| 4 | Codon catalog usage and the genome hypothesis 显示文摘 | Grantham R Gautier C Gouy M Mercier R Pave A | 1980 | Nucleic Acids Research1980，8，1： | 1 |
| 5 | The complete gabor-fisher classifier for robust face recognition 显示文摘 | Vitomir ?truc Nikola Pave?ic' | 2010 | EURASIP Journal on Advances in Signal Processing2010，2010，1： | 1 |
| 6 | The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes显示文摘 | PAVING HH LEHNERT H BROCHNER-MORTENSEN J | 2001 | N Engl J Med2001，345，12： | 1 |
| 7 | Chromosome variant lqh- and its influence on the 3D organization of chromosome 1 heterochromatin in interphase nucleus of patients with endometriosis 显示文摘 | Mikelsaar R Paves H Org K | 2014 | J Genet2014，93，1： | 1 |
| 8 | The role of insulin-like growth factor 2 and its receptors in human tumors显示文摘 | PAVELIC K BUKOVI(C) D PAVELI(C) J | 2002 | Mol Med2002，8，12： | 1 |
| 9 | Neurotrophins as in vitro growth cone guidance molecules for embryonic sensory neurons显示文摘 | Paves H Saarma M | 1997 | Cell Tissue Res1997，290，2： | 1 |
| 10 | 查看详情显示文摘 | Maloj(c)i(c) G Piantanida I Marini(c) M (Z)ini(c) M Marjanovi(c) M Kralj M Paveli(c) K Schneider H | | 0，，： | 1 |
| 11 | Variations in Doctor Effort:Evidence from Paraguay显示文摘 | Jishnu Das Thomas Pave Sohnesen | 2007 | Health Affairs2007，26，3： | 1 |
| 12 | Aspirin Has Antitumor Effects via Expression of Calpain Gene in Cervical Cancer Cells显示文摘 | Sang Koo Lee Min Seon Park Myeong Jin Nam Kre?imir Paveli? | 2008 | Journal of Oncology2008，，： | 1 |
| 13 | Biological and therapeutic effects of ortho-silicic acid and some ortho-silicic acid-releasing compounds:new perspectives for therapy显示文摘 | Jurki c'LM Cepanec I Paveli c'SK | 2013 | Nutr Metab(Lond)2013，10，1： | 1 |
| 14 | Loss of heterozygosity testing using real-time PCR analysis of single nucleotide polymorphisms显示文摘 | Tamara ?a?ev Mladen Joki? Radan Spaventi Kre?imir Paveli? Sanja Kapitanovi? | 2006 | Journal of Cancer Research and Clinical Oncology2006，，3： | 1 |
| 15 | Simulating the Interaction between a Society and a Renewable Resource显示文摘 | Bousquet B F C Cambier C Mullon P Morand J Quensiere and A Pave | 1993 | Journal of Biological Systems1993，，1： | 1 |
| 16 | PTCH gene altered in dentigerous cysts显示文摘 | Paveli B Levanat S Crni I | 2001 | J Oral Pathol Med2001，30，9： | 1 |
| 17 | Biological & physiological aspects of action of insulin-like growth factor peptide family显示文摘 | Paveli(c) J Matijevi(c) T Knezevi(c) J | 2007 | The Indian Jounal of Medical Research2007，125，4： | 1 |
| 18 | Responses of mango trees to reduced irrigationregimes 显示文摘 | Pave] E W de Villiers A J | 2004 | hcta Horticulturae2004，646，： | 1 |
| 19 | The Association between Corporate Social-Responsibility and Financial Performance:The Paradox of Social Cost显示文摘 | Pave M J Krausz | 1996 | Journal of Business Ethics1996，15，： | 1 |
| 20 | Liposomal gels for vaginal drug delivery显示文摘 | Pavelié Z Skalko-Basnet N Schubert RI | 2001 | Int J Pharm2001，219，12： | 1 |
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