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| 1 | Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD)is a condition in which excess fat accumulates in the liver of a patient with no history of alcohol abuse or other causes for secondary hepatic steatosis.The pathogenesis of NAFLD and nonalcoholic steatohepatitis(NASH)has not been fully elucidated.The'two-hit'hypothesis is probably a too simplified model to elaborate complex pathogenetic events occurring in patients with NASH.It should be better regarded as a multiple step process,with accumulation of liver fat being the first step,followed by the development of necroinflammation and fibrosis.Adipose tissue,which has emerged as anendocrine organ with a key role in energy homeostasis,is responsive to both central and peripheral metabolic signals and is itself capable of secreting a number of proteins.These adipocyte-specific or enriched proteins,termed adipokines,have been shown to have a variety of local,peripheral,and central effects.In the current review,we explore the role of adipocytokines and proinflammatory cytokines in the pathogenesis of NAFLD.We particularly focus on adiponectin,leptin and ghrelin,with a brief mention of resistin,visfatin and retinol-binding protein 4 among adipokines,and tumor necrosis factor-α,interleukin(IL)-6,IL-1,and briefly IL-18 among proinflammatory cytokines.We update their role in NAFLD,as elucidated in experimental models and clinical practice. | Sanja Stojsavljevi? Marija Gomer?i? Pal?i? Lucija Virovi? Juki? Lea Smir?i? Duvnjak Marko Duvnjak | 2014 | World Journal of Gastroenterology2014，20，48： | 42 |
| 2 | Scoring systems for peptic ulcer bleeding: which one to use?显示文摘AIM To compare the Glasgow-Blatchford score(GBS), Rockall score(RS) and Baylor bleeding score(BBS) in predicting clinical outcomes and need for interventions in patients with bleeding peptic ulcers. METHODS Between January 2008 and December 2013, 1012consecutive patients admitted with peptic ulcer bleeding(PUB) were prospectively followed. The pre-endoscopic RS, BBS and GBS, as well as the post-endoscopic diagnostic scores(RS and BBS) were calculated for all patients according to their urgent upper endoscopy findings. Area under the receiver-operating characteristics(AUROC) curves were calculated for the prediction of lethal outcome, rebleeding, needs for blood transfusion and/or surgical intervention, and the optimal cutoff values were evaluated.RESULTS PUB accounted for 41.9% of all upper gastrointestinal tract bleeding, 5.2% patients died and 5.4% patients underwent surgery. By comparing the AUROC curves of the aforementioned pre-endoscopic scores, the RS best predicted lethal outcome(AUROC 0.82 vs 0.67 vs0.63, respectively), but the GBS best predicted need for hospital-based intervention or 30-d mortality(AUROC0.84 vs 0.57 vs 0.64), rebleeding(AUROC 0.75 vs 0.61 vs 0.53), need for blood transfusion(AUROC 0.83 vs0.63 vs 0.58) and surgical intervention(0.82 vs 0.63 vs 0.52) The post-endoscopic RS was also better than the post-endoscopic BBS in predicting lethal outcome(AUROC 0.82 vs 0.69, respectively).CONCLUSION The RS is the best predictor of mortality and the GBS is the best predictor of rebleeding, need for blood transfusion and/or surgical intervention in patients with PUB. There is no one 'perfect score' and we suggest that these two tests be used concomitantly. | Ivan Budimir Sanja Stojsavljevic Neven Barsic Alen Biscanin Gorana Mirosevic Sven Bohnec Lora Stanka Kirigin Tajana Pavic Neven Ljubicic | 2017 | World Journal of Gastroenterology2017，23，41： | 6 |
| 3 | 盐酸溶液中双氧水浸出黄铜矿(英文)显示文摘本文旨在研究以双氧水为强氧化剂的黄铜矿精矿的盐酸浸出过程。研究搅拌速度、固液比、温度、HCl和H_2O_2浓度等浸出参数对金属浸出率的影响。室温下,用3.0 mol/L H_2O_2和0.5 mol/L HCl溶液与黄铜矿反应180 min后,获得33%的最大铜浸出率。结果表明,在反应的前60 min,铜的浸出率增大;此后,由于双氧水的快速催化分解,铜浸出率基本上保持不变。此外,固液比对铜的浸出率影响显著,而且在最稀的悬浮液中(即固液比1:100)铜的浸出率最高。溶出过程可用一级动力学方程描述,表观活化能为19.6 kJ/mol,表明溶出过程受扩散控制,对于HCl和H_2O_2的反应级数分别为0.30和0.53。浸出渣的XRD和SEM/EDS分析结果表明,矿物表面生成单质硫,抑制浸出率的提高。 | Sanja J.PETROVIC Grozdanka D.BOGDANOVIC Milan M.ANTONIJEVIC | 2018 | Transactions of Nonferrous Metals Society of China2018，28，7： | 6 |
| 4 | CFD simulation of single-phase flow in flotation cells:Effect of impeller blade shape,clearance,and Reynolds number显示文摘A series of numerical simulations of turbulent single-phase flows are performed to understand the flow and mixing characteristics in a laboratory scale flotation tank.Four impeller blade shapes covering a wide range of surface areas and lip lengths are considered to highlight and contrast the flow behavior predicted in the impeller stream.The mean flow close to the impeller is fully characterized by considering velocity components along the axial direction at different radial locations.Normalized results suggest the development of a comparatively stronger axial velocity component for a blade design with the smallest lip length,called big-tip impeller here.Normalized turbulent kinetic energy profiles close to the impeller reveal the existence of an asymmetric trailing vortex pair.The highest turbulence kinetic energy dissipation rates are observed close to the impeller blades and stator walls where the radial jet strikes the stator walls periodically.Furthermore,liquid phase mixing in the flotation cell is studied using transient scalar tracing simulations providing mixing time data.Finally,pumping capacity and efficiency of different impeller designs are calculated based on which the impeller blade design with a rectangular blade design is found to perform most efficiently. | Manjunath Basavarajappa Sanja Miskovic | 2019 | International Journal of Mining Science and Technology2019，29，5： | 5 |
| 5 | Problems in screening colorectal cancer in the elderly显示文摘AIM: To explore the problems in the screening of colorectal carcinoma in the elderly.METHODS: Three models of colorectal cancer prevention were examined: standard screening, active check-up of suspected cases and summons to have endoscopic checkup for previously diagnosed colorectal polyps. The study was performed among three groups of elderly individuals:Group 1 (167 cases), hospitalized asymptomatic individuals without symptoms in large intestines. Group 2 (612 cases):old individuals at home for the aged, out of which 32 showed symptoms of colon disorders; Group 3 (44 cases): elderly people with diagnosed polyps. As a result of 1788rectosigmoidoscopies, we identified 61 individuals with polyps, out of which 44 patients were over 65 years old.However, only 9 of these 44 individuals agreed to have the endoscopy performed again.RESULTS: One cancer and 13 polyps were detected in Group 1, and two polyps in Group 2. However, it should be noted that only eleven individuals from Group 2 agreed to have the endoscopy. In Group 3, there were no relapses of the polyps among the nine individuals who came back for the endoscopy.CONCLUSION: Poor understanding of the screening procedures is one of the greatest problems in early detection of the cancer in the aged. Paradoxically, the cooperation is better with hospitalized patients, than with 'successfully old'persons. | DavidoviM.Mladen Milosevic P.Dragoslav Zdravkovic Sanja Bojic Bozidar Djurica Snezana | 2003 | World Journal of Gastroenterology2003，9，10： | 4 |
| 6 | Vascularization and osteogenesis in ectopically implanted bone tissue-engineered constructs with endothelial and osteogenic differentiated adipose-derived stem cells显示文摘BACKGROUND A major problem in the healing of bone defects is insufficient or absent blood supply within the defect.To overcome this challenging problem,a plethora of approaches within bone tissue engineering have been developed recently.Bearing in mind that the interplay of various diffusible factors released by endothelial cells(ECs)and osteoblasts(OBs)have a pivotal role in bone growth and regeneration and that adjacent ECs and OBs also communicate directly through gap junctions,we set the focus on the simultaneous application of these cell types together with platelet-rich plasma(PRP)as a growth factor reservoir within ectopic bone tissue engineering constructs.AIM To vascularize and examine osteogenesis in bone tissue engineering constructs enriched with PRP and adipose-derived stem cells(ASCs)induced into ECs and OBs.METHODS ASCs isolated from adipose tissue,induced in vitro into ECs,OBs or just expanded were used for implant construction as followed:BPEO,endothelial and osteogenic differentiated ASCs with PRP and bone mineral matrix;BPUI,uninduced ASCs with PRP and bone mineral matrix;BC(control),only bone mineral matrix.At 1,2,4 and 8 wk after subcutaneous implantation in mice,implants were extracted and endothelial-related and bone-related gene expression were analyzed,while histological analyses were performed after 2 and 8 wk.RESULTS The percentage of vascularization was significantly higher in BC compared to BPUI and BPEO constructs 2 and 8 wk after implantation.BC had the lowest endothelial-related gene expression,weaker osteocalcin immunoexpression and Spp1 expression compared to BPUI and BPEO.Endothelial-related gene expression and osteocalcin immunoexpression were higher in BPUI compared to BC and BPEO.BPEO had a higher percentage of vascularization compared to BPUI and the highest CD31 immunoexpression among examined constructs.Except Vwf,endothelial-related gene expression in BPEO had a later onset and was upregulated and well-balanced during in vivo incubation that induced late onset of Spp1 expression and pronounced osteocalcin immunoexpression at 2 and 8 wk.Tissue regression was noticed in BPEO constructs after 8 wk.CONCLUSION Ectopically implanted BPEO constructs had a favorable impact on vascularization and osteogenesis,but tissue regression imposed the need for discovering a more optimal EC/OB ratio prior to considerations for clinical applications. | Jelena G Najdanović Vladimir J Cvetković Sanja T Stojanović MarijaĐVukelić-Nikolić Jelena MŽivković Stevo J Najman | 2021 | World Journal of Stem Cells2021，13，1： | 3 |
| 7 | Dynamics of steam accumulation显示文摘 | Vladimir D. Stevanovic Blazenka Maslovaric Sanja Prica | 2012 | Applied Thermal Engineering2012，，： | 3 |
| 8 | Primary retroperitoneal mucinous cystadenoma:A case report显示文摘Primary retroperitoneal mucinous cystic tumors are extremely rare.These tumors can be classified as a primary retroperitoneal mucinous cystadenoma with or without borderline malignancy or primary retroperitoneal mucinous cystadenocarcinoma.The most common of these is primary retroperitoneal mucinous cystadenoma,which almost always occurs in female patients;only ten cases have been reported in males.The most common clinical findings for this tumor type include nonspecific abdominal pain and a palpable abdominal mass.A definitive diagnosis is usually obtained from histopathology after surgical excision.Here,we report the case of a 60-year-old female patient who complained of abdominal pain that had been present for 3 mo and presented with a palpable abdominal mass.Multidetector computed tomography scanning revealed a large,unilocular cystic mass in the left retroperitoneal space.Surgical intervention was performed and the tumor was completely removed.Histopathologic examination confirmed that the tumor was a primary retroperitoneal mucinous cystadenoma.Two years after surgery,the patient remains disease free. | Srbislav Knezevic Igor Ignjatovic Snezana Lukic Slavko Matic Vladimir Dugalic Djordje Knezevic Marjan Micev Sanja Dragasevic | 2015 | World Journal of Gastroenterology2015，21，17： | 3 |
| 9 | Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice显示文摘 | Prakash G. Chandak Sascha Obrowsky Branislav Radovic Prakash Doddapattar Elma Aflaki Adelheid Kratzer Lalit S. Doshi Silvia Povoden Helmut Ahammer Gerald Hoefler Sanja Levak-Frank Dagmar Kratky | 2011 | BBA - Molecular and Cell Biology of Lipids2011，，12： | 3 |
| 10 | Analysis of the in vitro degradation and the in vivo tissue response to bi-layered 3D-printed scaffolds combining PLA and biphasic PLA/bioglass components--Guidance of the inflammatory response as basis for osteochondral regeneration显示文摘The aim of the present study was the in vitro and in vivo analysis of a bi-layered 3D-printed scaffold combining a PLA layer and a biphasic PLA/bioglass G5 layer for regeneration of osteochondral defects in vivo Focus of the in vitro analysis was on the(molecular)weight loss and the morphological and mechanical variations after immersion in SBF.The in vivo study focused on analysis of the tissue reactions and differences in the implant bed vascularization using an established subcutaneous implantation model in CD-1 mice and established histological and histomorphometrical methods.Both scaffold parts kept their structural integrity,while changes in morphology were observed,especially for the PLA/G5 scaffold.Mechanical properties decreased with progressive degradation,while the PLA/G5 scaffolds presented higher compressive modulus than PLA scaffolds.The tissue reaction to PLA included low numbers of BMGCs and minimal vascularization of its implant beds,while the addition of G5 lead to higher numbers of BMGCs and a higher implant bed vascularization.Analysis revealed that the use of a bi-layered scaffold shows the ability to observe distinct in vivo response despite the physical proximity of PLA and PLA/G5 layers.Altogether,the results showed that the addition of G5 enables to reduce scaffold weight loss and to increase mechanical strength.Furthermore,the addition of G5 lead to a higher vascularization of the implant bed required as basis for bone tissue regeneration mediated by higher numbers of BMGCs,while within the PLA parts a significantly lower vascularization was found optimally for chondral regeneration.Thus,this data show that the analyzed bi-layered scaffold may serve as an ideal basis for the regeneration of osteochondral tissue defects.Additionally,the results show that it might be able to reduce the number of experimental animals required as it may be possible to analyze the tissue response to more than one implant in one experimental animal. | Mike Barbeck Tiziano Serra Patrick Booms Sanja Stojanovic Stevo Najman Elisabeth Engel Robert Sader Charles James Kirkpatrick Melba Navarro Shahram Ghanaati | 2017 | Bioactive Materials2017，2，4： | 3 |
| 11 | Coagulation and Endothelial Dysfunction Associated with NAFLD:Current Status and Therapeutic Implications显示文摘Non-alcoholic fatty liver disease(NAFLD)is closely related to insulin resistance,type 2 diabetes mellitus,and obesity.It is nowadays considered a multisystem disease with a strong association with cardiovascular disease and arterial hypertension,which interfere with changes in the coagulation system.Coagulation disorders are common in patients with hepatic impairment and are dependent on the degree of liver damage.Patients with NAFLD may have preserved overall hemostatic profile,but many studies suggest a trend toward a procoagulant state.Hypercoagulable state in NAFLD patients may even induce progression of hepatic injury.Endothelial dysfunction is present in the systemic and portal vein circulation in NAFLD patients,and platelets are being recognized as modulators of liver diseases through various mechanisms.Through a literature review,we discuss possible disorders in the coagulation cascade and fibrinolysis,endothelial dysfunction,and platelet abnormalities in patients with NAFLD.Considering the processes and mechanisms involved in the hemostatic abnormalities associated with NAFLD,directly related to liver disease or indirectly related through inflam-matory processes and metabolic disorders,several potential therapeutic targets have been identified and reviewed here. | Doris Ogresta Anna Mrzljak Maja Cigrovski Berkovic Ines Bilic-Curcic Sanja Stojsavljevic-Shapeski Lucija Virovic-Jukic | 2022 | Journal of Clinical and Translational Hepatology2022，10，2： | 3 |
| 12 | Dynamics of steam accumulation显示文摘 | Vladimir D. Stevanovic Blazenka Maslovaric Sanja Prica | 2012 | Applied Thermal Engineering2012，，： | 2 |
| 13 | Trace element study in Tisa River and Danube alluvial sediment in Serbia显示文摘污染沉积担任有毒的元素的长期的来源,自从在这些元素的环境的那活动性和运输强烈被影响到联系稳固的阶段。在这研究,修改 Tessier 顺序的抽取过程被申请 Cd 的分别,同样在沉积的 Hg , Cu , Zn , Cr , Pb , Ni 和 V ( Tisa 河和运河沉积-多瑙河冲积形成),通过它的空间分发在这些区域获得踪迹元素污染的一个全面分类。这个区域的调查由于在整个 Tisa 和多瑙河排水盆和有在研究地区的有毒的元素的污染的可能性的金属采矿活动的普遍出现是重要的。顺序的抽取过程的五步把元素划分了成 CH3COONH4 可引出(F1 ) ,可引出、容易可约的 NH2OHHC 碳酸盐(F2 ) , H2C2O4/(NH4 ) 2C2O4 中等可约(F3 ) , H2O2HNO3 器官可引出(F4 ) ,并且 HCl 酸可溶的残余(F5 ) 。摘录的分析被火焰执行原子吸收 spectrometry。为了显示有毒的元素,风险评价代码和污染因素的风险的度,被使用了。划分学习的结果显示那更容易动员了形式(在到非结晶的 Fe 和 Fe 和 Mn 氧化物的 adsorbed/exchangeable/carbonate 形式或界限的金属) 为铜,锌,镉和铅是占优势的,它能从人为的来源为输入被用作指示物。相反,大量铬和镍与惰性的部分被联系,它减少了他们的溶解度并且在自然起源的自然条件和陈述语气下面使他们变为不动。仍然是金属的部分的大多数被绑在铁锰合金氧化物部分。顺序的抽取结果证明有用区分在之间,这被结束人为并且在沉积的元素的 geochemical 来源。 | Sanja M.SAKAN Nenad M.SAKAN Dragana S.DORDEVIC | 2013 | International Journal of Sediment Research2013，28，2： | 2 |
| 14 | root uv-b sensitive Mutants Are Suppressed by Specific Mutations in ASPARTATE AMINOTRANSFERASE2 and by Exogenous Vitamin B6显示文摘维生素 B6 (vitB6 ) 为超过 140 酶用作一个必要余因子。Pyridoxal 5'-phosphate (PLP ) , vitB6 的活跃余因子形式,能被 ultraviolet-B (UV-B ) 的踪迹数量 photolytically 破坏。暴露太阳的有机体怎么应付 PLP 光敏度并且调制 vitB6 动态平衡,当前是未知的。我们以前在二 Arabidopsis 异种, rus1 和 rus2 上报导了,那是过分敏感的跟踪 UV-B 光的数量。我们为 rus 异种显型的秒地点 suppressors 执行了 mutagenesis 屏幕并且在 ASPARTATE AMINOTRANSFERASE2 (ASP2 ) 基因识别了变化。ASP2 为 cytosolic aspartate aminotransferase (AAT ) 编码,在碳和氮起一个关键作用的 PLP 依赖的酶新陈代谢。基因分析证明了在 ASP2 的特定的氨基酸替换制服 rus1 和 rus2 单身者异种以及 rus1 rus2 的显型两倍异种。这些替换,都出现在 PLP 有约束力的衣袋里住在特定的位置,导致了没有 PLP 绑定。废除 AAT 的另外的 asp2 异种酶的活动,但是它在 PLP 有约束力的衣袋外面改变氨基酸,没能压制 rus 显型。而且,外长地在生长媒介增加 vitB6 能救 rus1 和 rus2。我们的数据建议 AAT 在 Arabidopsis 在 vitB6 动态平衡起一个作用。 | Colin D. Leasure Hong-Yun Tong Xue-Wen Hou Amy Shelton Mike Minton Raymond Esquerra Sanja Roje Hanjo Hellmann Zheng-Hui He | 2011 | Molecular Plant2011，4，4： | 2 |
| 15 | Sorption Behavior of Some Chlorophenols in Natural Sediments显示文摘 | Zlatko F Sanja F Vlasta D | 1994 | The Science of the Total Environment1994，155，： | 1 |
| 16 | Optimization of passive solar design strategies: A review 显示文摘 | Sanja S | 2013 | Renewable and Sus- tainable Energy Reviews2013，25，： | 1 |
| 17 | Recent developments in solid-phase microextraction显示文摘 | Sanja Risticevic Vadoud H. Niri Dajana Vuckovic Janusz Pawliszyn | 2009 | Analytical and Bioanalytical Chemistry2009，，3： | 1 |
| 18 | Age- and Region-Dependent Changes in Human Lumbar Vertebral Bone: A Histomorphometric Study显示文摘 | Olga Cvijanovic Dragica Bobinac Sanja Zoricic Zdenko Ostojic Ivana Maric Zeljka Crncevic-Orlic Ines Kristofic Ljerka Ostojic | 2004 | Spine2004，，21： | 1 |
| 19 | Dynamic mechanical and thermal properties of MAPE treated jute/HDPE compos- ites显示文摘 | SMITA M SUSHIL K V SANJA K N | 2006 | Compos Sci Technol2006，66，： | 1 |
| 20 | Complex expression changes of the placental en- dothelin system in early and late onset preeclampsia, fetal growth restriction and gestational diabetes 显示文摘 | Martina Dieber - Rotheneder Sanja Beganovic Gernot Desoye | 2012 | Life Sci2012，，91： | 1 |
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