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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Laparoscopic resection of exocrine carcinoma in central and distal pancreas results in a high rate of radical resections and long postoperative survival显示文摘 | Irina Pavlik Marangos Trond Buanes B?rd I. R?sok Airazat M. Kazaryan Arne R. Rosseland Krzysztof Grzyb Olaug Villanger ?ystein Mathisen Ivar P. Gladhaug Bj?rn Edwin | 2012 | Surgery2012，，5： | 3 |
| 3 | Long-Term Outcome of Laparoscopic Surgery for Pancreatic Neuroendocrine Tumors显示文摘 | Sven-Petter Haugvik Irina Pavlik Marangos B?rd Ingvald R?sok Ewa Pomianowska Ivar Prydz Gladhaug ?ystein Mathisen Bj?rn Edwin | 2013 | World Journal of Surgery2013，，3： | 2 |
| 4 | Calculation and reduction of stray and eddy losses in core-form transformers using a highly accurate finite element modeling technique显示文摘 | PAVLIK D JOHNSON D C | 1993 | IEEE Transactions on Power Delivery1993，8，1： | 1 |
| 5 | Vest chest physiother- apy airway clearance is associated with nitric oxide metabo- lism 显示文摘 | Sisson JH Wyatt TA Pavlik JA | 2013 | Pulmonary medicine2013，，29： | 1 |
| 6 | RACK1, a PKC targeting protein, is exclusively localized to basal airway epithelial cells显示文摘 | Slager RE Devasure JM Pavlik JA | 2008 | J Histochem Cytochem2008，56，1： | 1 |
| 7 | Non-invasive imaging in the diagnosis of acute viral myocarditis 显示文摘 | Jeserich M Konstantinides S Pavlik G | 2009 | Clin Res Cardiol2009，98，12： | 1 |
| 8 | Transvaginal sonography as a screening method for the detection of early ovarian cancer Gynecol显示文摘 | De Priest PD Gallion HH Pavlik EJ | 1997 | Oncol1997，65，： | 1 |
| 9 | Fungitoxieity of natural heteroeyele glueoside vieine obtained from Vicia faba against selected microscopic filamentous fungi显示文摘 | Pavlik M Laudova V Harmatha J | 2002 | Rostlinna- Vyroba UZPI (Czech Republic)2002，48，12： | 1 |
| 10 | Mass spectral analysis of a protein complex using singlechain antibodies selected on apeptide target: applications to functional genomics 显示文摘 | Siegell RW Allen1 B Pavlik P | 2000 | Mol Biol2000，302，2： | 1 |
| 11 | Determination of moisture diffusivity as a function of both moisture and temperature显示文摘 | Pavlik Z erny R | 2012 | In- ternational Journal of Thermophysics2012，33，89： | 1 |
| 12 | High -performance liquid chromatographic analysis and separation of N - feruloylserotonin isomers 显示文摘 | PAVLIK M LAUDOVA V GRUNER K | 2002 | Journal of Chromatography B2002，770，： | 1 |
| 13 | Ovarian volume related to age 显示文摘 | Pavlik EJ Depriest PD Gallion H | 2000 | Gynecol Oncol2000，77，3： | 1 |
| 14 | Prenatal diagnosis of acrania associated with amniotic band syndrome显示文摘 | Cincore V Ninios A P Pavlik J | 2003 | Obstet Gyneco12003，102，52： | 1 |
| 15 | Bullous pemphigoid and internaldiseases-A case-control study 显示文摘 | Jedlickova H Hlubinka M Pavlik T | 2010 | Eur J Dennatol2010，20，1： | 1 |
| 16 | Clinical implications of a ris- ing serum CA-125 within the normal range in patients with epithelial ovarian cancer : a preliminary investigation 显示文摘 | Wilder JL Pavlik E Straughn JM | 2003 | Gynecol Oncol2003，89，2： | 1 |
| 17 | Identification of cerebral neurons and glial cell types inducing heat shock protein Hsp70 following heat stress in the rat显示文摘 | Pavlik A Aneja IS Lexa J | 2003 | Brain Res2003，973，2： | 1 |
| 18 | Highperformance liquid chromatographic analysis and separation of N-feruloylserotonia isomers 显示文摘 | PAVLIK M LAUDOVA V GRUNER K | 2002 | Chromatogram2002，770，： | 1 |
| 19 | Hypertension aware ness and control in an inner-city African-American sample显示文摘 | Pavlik V N Hyman D J Vallbona C | 1997 | J Hum Hypertens1997，11，5： | 1 |
| 20 | Differences in the association of peripheral insulin and cognitive function in non-diabetic Alzheimer's disease cases and normal controls显示文摘 | Pavlik V Massman P Barber R | 2013 | J Alzheimers Dis2013，34，2： | 1 |
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