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| 1 | Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology显示文摘Inflammatory bowel diseases(IBDs),such as ulcerative colitis and Crohn's disease,are chronic pathologies associated with a deregulated immune response in the intestinal mucosa,and they are triggered by environmental factors in genetically susceptible individuals.Exogenous glucocorticoids(GCs)are widely used as anti-inflammatory therapy in IBDs.In the past,patients with moderate or severe states of inflammation received GCs as a first line therapy with an important effectiveness in terms of reduction of the disease activity and the induction of remission.However,this treatment often results in detrimental side effects.This downside drove the development of second generation GCs and more precise(non-systemic)drugdelivery methods.Recent clinical trials show that most of these new treatments have similar effectiveness to first generation GCs with fewer adverse effects.The remaining challenge in successful treatment of IBDs concerns the refractoriness and dependency that some patients encounter during GCs treatment.A deeper understanding of the molecular mechanisms underlying GC response is key to personalizing drug choice for IBDs patients to optimize their response to treatment.In this review,we examine the clinical characteristics of treatment with GCs,followed by an in depth analysis of the proposed molecular mechanisms involved in its resistance and dependence associated with IBDs.This thorough analysis of current clinical and biomedical literature may help guide physicians in determining a course of treatment for IBDs patients and identifies important areas needing further study. | Karen Dubois-Camacho Payton A Ottum Daniel Franco-Munoz Marjorie De la Fuente Alejandro Torres-Riquelme David Díaz-Jiménez Mauricio Olivares-Morales Gonzalo Astudillo Rodrigo Quera Marcela A Hermoso | 2017 | World Journal of Gastroenterology2017，23，36： | 6 |
| 2 | Enhanced photochemical light utilization and decreased chilling induced photo inhibition of photosystem Ⅱ in cotton over expressing genes encoding chloroplast-targeted anti oxidant enzymes显示文摘 | Komyeyev D Logan BA Payton P | | 0，，： | 1 |
| 3 | Induction of tumorigen-esis and metastasis by the murine orthologue of tumor protein D52 显示文摘 | Lewis J D Payton L A Whitford J G | 2007 | Mol Cancer Res2007，5，2： | 1 |
| 4 | Privacy of Medical Re-cords :IT implications of HIPAA 显示文摘 | Baumer D Earp J B Payton F C | 2000 | ACM SIGCAS Com-puters and Society2000，30，4： | 1 |
| 5 | Influence of place attachment and trust on civic action: a study at Sherburne National Wildlife Refuge显示文摘 | Payton M A Fulton D C Anderson D H | 2005 | Society & Natural Resources2005，18，6： | 1 |
| 6 | On the formation andgrowth of intermetallic phases during interdiffusion betweenlow-carbon steel and aluminum alloys 显示文摘 | SPRINGER H KOSTKA A PAYTON E J RAABE D KAYSSER-PYZALLA A EGGELER G | 2011 | Acta Materialia2011，59，4： | 1 |
| 7 | Material recovery and re-use technologies for the paper industry显示文摘 | Phipps J S Skuse D R Payton D C | 1999 | Paper Technology1999，40，1： | 1 |
| 8 | Induction of tumorigen- esis and metastasis by the murine orthologue of tumor protein D52 显示文摘 | Lewis J D Payton L A Whitford J G | 2007 | Mol Cancer Res2007，5，2： | 1 |
| 9 | Enhanced photo- chemical light utilization and decreased chilling-induced photoin- hibition of photosystem Ⅱ in cotton overexpressing genes enco- ding chloroplast-targeted antioxidant enzymes 显示文摘 | Kornyeyev D Logan B A Payton P | 2001 | Physiologia Plantarum2001，113，3： | 1 |
| 10 | The use of unmanned aerial systems for the mapping of leg- acy uranium mines显示文摘 | Martin P G Payton O D Fardoulis J S | 2015 | Journal of Environmental Ra- dioactivity2015，，143： | 1 |
| 11 | Enhanced photochemical light utilization and decreased chilling-induced photoinhibition of photosystem II in cotton overex-pressing genes encoding chloroplast-targeted antioxidant enzymes 显示文摘 | Komyeyev D Logan B A Payton P et ol | 2001 | Physiologia Plantarum2001，113，3： | 1 |
| 12 | ESTs, cDNA microarray, and gene expression profiling : tools for dissecting plant physiology and development显示文摘 | AIBA R FEI Z J PAYTON P LIU Y MOORE S L DEBBIE P COHN J D'ASCENZO M GORDON J S JOCELYN K C ROSE MARTIN G TANKSLEY S D BOUZAYEN M JAHN M M GIOVANNONI J | 2004 | Plant Journal2004，39，5： | 1 |
| 13 | Isolation and Antimicrobial Susceptibilities of Bacterial Pathogens from Bovine Pneumonia: 1994-2002 显示文摘 | Welsh R D Dye L B Payton M E | 2004 | J Vet Diagn Invest2004，16，： | 1 |
| 14 | Pheromone robotics显示文摘 | Payton D Daily M Estkowski R | 2001 | Autonomous Robots2001，11，3： | 1 |
| 15 | On the formation and growth of intermetallic phases during interdiffusion between low-carbon steel and aluminum alloys显示文摘 | SPRINGER H KOSTKA A PAYTON E J RAABE D KAYSSER-PYZALLA A EGGELER G | 2011 | Acta Materialia2011，59，4： | 1 |
| 16 | Lightweight aerial vehicles for monitoring, assessment and mapping of radiation anomalies 显示文摘 | Macfarlane 3 W Payton O D Keatley A C | 2014 | Journal of Environmental Radioactivity2014，，136： | 1 |
| 17 | Effect of plant fill ratio on water temperature in constructed wetlands显示文摘 | D T Hill J D Payton | 2000 | Bioresource Thechnology2000，，71： | 1 |
| 18 | Comparison of laparoscopic ovariohysterectomy and ovariohysterectomy in dogs显示文摘 | Davidson E B Moll H D Payton M E | 2004 | Vet Surg2004，33，4： | 1 |
| 19 | Pheromone robotics显示文摘 | Payton D Daily M | 2001 | Autonomous Robots2001，11，： | 1 |
| 20 | Effect of nicotinic acid on rumen fermentation in vitro and in vivo显示文摘 | Riddell D O Bartley E E Payton A D | 1980 | J Dairy Sci1980，63，： | 1 |
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