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| 1 | Role of microglial cells in photoreceptor degeneration显示文摘Inherited photoreceptor degeneration in humans constitutes a major cause of irreversible blindness in the world.They comprise various diseases,but retinitis pigmentosa is the most frequently observed.Retinitis pigmentosa is commonly limited to the eye,where there is progressive photoreceptor degeneration,rods and secondarily cones.The mechanisms of cone and rod degeneration continue to be investigated,since most of the mutations causing retinitis pigmentosa affect rods and thus,the secondary death of cones is an intriguing question but,ultimately,the cause of blindness.Understanding the mechanisms of rod and cone degeneration could help us to develop therapies to stop or,at least,slow down the degeneration process.Secondary cone degeneration has been attributed to the trophic dependence between rods and cones,but microglial cell activation could also have a role.In this review,based on previous work carried out in our laboratory in early stages of photoreceptor degeneration in two animal models of retinitis pigmentosa,we show that microglial cell activation is observed prior to the the initiation of photoreceptor death.We also show that there is an increase of the retinal microglial cell densities and invasion of the outer retinal layers by microglial cells.The inhibition of the microglial cells improves photoreceptor survival and morphology,documenting a role for microglial cells in photoreceptor degeneration.Furthermore,these results indicate that the modulation of microglial cell reactivity can be used to prevent or diminish photoreceptor death in inherited photoreceptor degenerations. | Johnny Di Pierdomenico Diego García-Ayuso Marta Agudo-Barriuso Manuel Vidal-Sanz María Paz Villegas-Pérez | 2019 | Neural Regeneration Research2019，14，7： | 4 |
| 2 | Embryonal rhabdomyosarcoma in the maxillary sinus with orbital involvement in a pediatric patient:Case report显示文摘This report presents a case of embryonal rhabdomyosarcoma(e RMS) located in the left maxillary sinus and invading the orbital cavity in a ten-year-old male patient who was treated at a referral hospital.The images provided from the computed tomography showed a heterogeneous mass with soft-tissue density,occupying part of the left half of the face inside the maxillary sinus,and infiltrating and destroying the bone structure of the maxillary sinus,left orbit,ethmoidal cells,nasal cavity,and sphenoid sinus.An analysis of the histological sections revealed an undifferentiated malignant neoplasm infiltrating the skeletal muscle tissue.The immunohistochemical analysis was positive for the antigens:MyoD 1,myogenin,desmin,and Ki67(100% positivity in neoplastic cells),allowing the identification of the tumour as an eR MS.The treatment protocol included initial chemotherapy followed by radiotherapy and finally surgery.The total time of the treatment was nine months,and in 18-mo of follow-up period did not show no local recurrences and a lack of visual impairment. | Ana Carolina Rodrigues de Melo Tácio Candeia Lyra Isabella Lima Arrais Ribeiro Alexandre Rolim da Paz Paulo Rogério Ferreti Bonan Ricardo Dias de Castro Ana Maria Gondim Valen?a | 2017 | World Journal of Clinical Cases2017，5，12： | 3 |
| 3 | Photooxidatively self-cleaning transparent titanium dioxide films on soda lime glass: The deleterious effect of sodium contamination and its prevention显示文摘 | Paz Y Heller A | 1997 | Journal of Materials Research1997，12，10： | 1 |
| 4 | Improved cotyledonary node method using an alternative explant derived from mature seed for efficient Agrobacterium-mediated soybean transformation 显示文摘 | Paz M M Martinez J C Kalvig A B | 2006 | Plant Cell Reports2006，25，3： | 1 |
| 5 | Enhancement of fruit sensory quality by post-harvest applications of acetaldehyde and ethanol: blueberries, tomatoes, pears显示文摘 | PAZ O JANES H W PREVOST B A | 1982 | Food Science1982，47，1： | 1 |
| 6 | Interlaboratory transfer of a real-time polymerase chain reactionassay for quantitative detection of genetically modifiedmaize event TC-1507显示文摘 | La Paz J L Garcia-Muniz N Nadal A | 2006 | Journal of AOAC International2006，89，5： | 1 |
| 7 | Soil quality : A new index based on microbiological and biochemical parameters 显示文摘 | Paz Jimenez M D Horra A M Peuzzo L | 2002 | Biology and Fertility of Soils2002，35，： | 1 |
| 8 | A GIS-based multivariate statistical analy-sis for shallow landslide susceptibility mapping in La Po-bla de Lillet area ( Eastern Pyrenees, Spain) 显示文摘 | Santacana N Baeza B Corominas J De Paz A Marturia J | 2003 | Natural Hazards2003，30，： | 1 |
| 9 | Ferroelectric thin films in integrated microelectronic devices 显示文摘 | Scott J F Paz de Araujo C A McMillan L D | 1992 | Ferroelectrics1992，133，： | 1 |
| 10 | Asymptomatic visceral leishmaniasis in Isral显示文摘 | Ephros M Paz A Jaffe CL | 1994 | Trans R Soc Trop Med Hyg1994，88，6： | 1 |
| 11 | Microwave-assisted synthesis of metal-organieframeworks显示文摘 | Klinowski J Paz F A A Silva P | 2011 | Dalton Transactions2011，40，： | 1 |
| 12 | The usefulm ness of MR imaging in the diagnosis of dysembryoplastic neu- roepithelial tumor in childrcn:a study of 14 cases 显示文摘 | Fernandez C Girard N Paz Paredes A | 2003 | AJNR2003，24，5： | 1 |
| 13 | Diterpenoids from Lycopus europaeus and Nepeta septemcrenata:Revised structures and new isopimarane derivatives显示文摘 | Ahmed A Hussein Benjamín Rodríguez María de la Paz Martínez-Alcáizar | | 0，，： | 1 |
| 14 | Interlaboratory transfer of a real-time polymerase chain reaction assay for quantitative detection of genetically modifiedmaize event TC-1507显示文摘 | La Paz J L Garcia-Muniz N Nadal A | 2006 | Journal of AOAC International2006，89，5： | 1 |
| 15 | Fatigue-free Ferroelectric Capacitors with Platinum Electrodes显示文摘 | Cuchiaro J D Scott J F | 1995 | Nature1995，374，： | 1 |
| 16 | Improved cotyledonary node method using an alternative explant derived from mature seed for efficient Agrobacterium-mediated soybean transformation 显示文摘 | Paz M M Martinez J C Kalvig A B | 2006 | Plant Cell Report2006，25，3： | 1 |
| 17 | Comparison of radionuclide scrotal blood-pool index verses gonadal venography in the diagnosis of varicocele显示文摘 | Melloul M | 1998 | J Nucl Med1998，39，6： | 1 |
| 18 | Photo-oxidatively self cleaning transparent titanium dioxide films on sodalime glass the deleterious effect of sodium contamination and its prevention显示文摘 | PAZ Y HELLER A | 1997 | J Mater Res1997，12，： | 1 |
| 19 | Double-phase 99mTc-sestamibi scintimammography and trans-scan in diagnosing breast cancer显示文摘 | Melloul M Paz A Ohana G | 1999 | J Nucl Med1999，40，3： | 1 |
| 20 | Characterisation of okadaic acid related toxins by liquid chromatography coupled with mass spectrometry显示文摘 | PAZ B H DARANAS A CRUZ P | 2007 | Toxicon2007，50，： | 1 |
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