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| 1 | Immunological roulette: Luck or something more? Considering the connections between host and environment in TB显示文摘Accurate prediction of which patient will progress from a sub-clinical Mycobacterium tuberculosis infection to active tuberculosis represents an elusive,yet critical,clinical research objective.From the individual perspective,progression can be considered to be the product of a series of unfortunate events or even a run of bad luck.Here,we identify the subtle physiological relationships that can influence the odds of progression to active TB and how this progression may reflect directed dysbiosis in a number of interrelated systems.Most infected individuals who progress to disease have apparently good immune responses,but these responses are,at times,compromised by either local or systemic environmental factors.Obvious disease promoting processes,such as tissue-damaging granulomata,usually manifest in the lung,but illness is systemic.This apparent dichotomy between local and systemic reflects a clear need to define the factors that promote progression to active disease within the context of the body as a physiological whole.We discuss aspects of the host environment that can impact expression of immunity,including the microbiome,glucocorticoid-mediated regulation,catecholamines and interaction between the gut,liver and lung.We suggest the importance of integrating precision medicine into our analyses of experimental outcomes such that apparently conflicting results are not contentious,but rather reflect the impact of these subtle relationships with our environment and microbiota. | John E Pearl Mrinal Das Andrea M Cooper | 2018 | Cellular & Molecular Immunology2018，15，3： | 3 |
| 2 | Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury显示文摘 | Caudrillier Axelle Kessenbrock Kai Gilliss Brian M Nguyen John X Marques Marisa B Monestier Marc Toy Pearl Werb Zena Looney Mark R | 2012 | EN2012，，7： | 2 |
| 3 | Pancreatic islets under attack: cellular and molecular effectors 显示文摘 | Pearl Yafe M Kaminitz A Yolcu ES | 2007 | Curr Pharm Des2007，13，7： | 1 |
| 4 | Interferon - gamma and bacterial lipopolysaccharide act synergistically on human neutrophils enhancing interleukin - 8, interleukin - 1 beta, tumor necrosis factor - alpha,and interleukin- 12 p70 secretion and phagocytosis via upregulation of toll - like receptor 4 显示文摘 | Pearl - Yafe M Fabian I Halperin D | 2007 | Shock2007，27，3： | 1 |
| 5 | Immunopathogenesis of hepatitis C viral infection: Th1/Th2 responses and the role of cytokines显示文摘 | Pearl M Jacobson Brown Manuela G Neuman | 2001 | Clinical Biochemistry2001，，3： | 1 |
| 6 | Urologic diseases in America project: urolithiasis显示文摘 | Pearle M S Calhoun E A Curhan G C | 2005 | J Urol2005，173，： | 1 |
| 7 | ACC/AHA guidelines for the martagement of patients with ST-elevation myocardial infarction-executive summary:port of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of patients with Acute Myocardial Infarction) 显示文摘 | Antman EM Anbe DT Armstrong PW Bates ER Green LA Hand M Hochman JS Krumholz HM Kushner FG Lamas GA Mullany CJ Ornato JP pearle DL Sloan MA Smith SCJr Alpert JS Anderson JL Faxon DP Fuster V Gibbons RJ Gregoratos G Halperin JL Hiratzka LF Hunt SA Jacobs AK American College of Cardiology American Heart Association Task Force on Practice Guidelines | 2004 | Circulation2004，110，5： | 1 |
| 8 | PMO-247 Mucosal cytokine expression inulcerative colitis:elevated IL- 8 but not TNF-ct and raduced TGF-13 in inflamed compared to non-in-flamed mucosa 显示文摘 | PEARL D S SHAH K WHITTAKER M | 2012 | Gut2012，61，2： | 1 |
| 9 | Prospective randomized trial comparing shock wave lithotripsy and ureteroscopy for management of distal ureteral calculi显示文摘 | Pearle M S Nadler R Bercowsky E etal | 2001 | J Urol2001，166，： | 1 |
| 10 | Confounding ahd Collapsibility in Causal Inference显示文摘 | Greenland S Robins J M Pearl J | 1999 | Statistical Science1999，14，1： | 1 |
| 11 | 'Malignant' uterine perivascular epithelioid cell tumor,pelvic lymph node lymphangioleiomyo matosis,and gynecological PEComatosis in a patient with tubero us sclerosis:a case report and review of the literature显示文摘 | LIANG SX PEARL M LIU J | 2008 | Int J Gyn ecol Pathol2008，27，4： | 1 |
| 12 | Complications of ureteroscopy显示文摘 | Johnson D B Pearle M S | 2004 | Urol Clin North Am2004，31，1： | 1 |
| 13 | Approach to common abdo- minal diagnosis in infants and children显示文摘 | Pearl R H Irish M S Caty M G I | 1998 | Pedi Clin Nor Am1998，45，6： | 1 |
| 14 | Complications of ureter - oscopy 显示文摘 | JOHNSON D B PEARLE M S | 2004 | Urol Clin North Am2004，31，1： | 1 |
| 15 | Management options for lo - wet pole renal calculi 显示文摘 | RAMAN J D PEARLE M S | 2008 | Curr Opin Urol2008，18，： | 1 |
| 16 | Complications of ureteroscopy显示文摘 | Johnson D B Pearle M S | 2004 | Urol Clin North Am2004，31，1： | 1 |
| 17 | Appendectomy: a contemporary appraisa显示文摘 | Hale DA Molloy M Pearl RH | 1997 | Ann Surg1997，225，3： | 1 |
| 18 | Development of Xenopusresource centers:The national Xenopus re-source and the European Xenopus resource center显示文摘 | Pearl E J Grainger R M Guille M | 2012 | Genesis2012，50，3： | 1 |
| 19 | Exploring the relationship of second-trimester eorticotropin releasing hormone, ehronie stressand preterm delivery 显示文摘 | Guendelman S Kosa JL Pearl M | 2008 | Matern Fetal Neonatal Med2008，21，11： | 1 |
| 20 | Causal diagrams for epidemiologic research显示文摘 | GREENLAND S PEARL J ROBINS J M | 1999 | Epidemiology1999，10，1： | 1 |
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