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174篇 您的检索式：作者名="Pearson I"

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	题名	作者	年代	出处	被引量
1	NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease显示文摘AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients.METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.Monocytes were challenged with MAP and bacterial persistence assessed at subsequent time-points.Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines.RESULTS:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those without.There was no effect of NOD2 genotype on subsequent cytokine expression.The T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD.	Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley	2011	World Journal of Gastroenterology2011，17，23：	2
2	Active control of helicopter vibration 显示文摘	Pearson J T Goodall R M Lyndon I	1994	Computing & Control Engineering Journal1994，5，6：	1
3	Tissue culture of the enteric nervous system from equine Ileum 显示文摘	Hudson N P H Pearson G T Mayhew I G	2000	Veterinary Research Communications2000，24，：	1
4	A Social History of the Mobile Telephone with a View of its Future显示文摘	H Lacohée N Wakeford I Pearson	2003	BT Technology Journal2003，，3：	1
5	The lipid treatment assessment project (L-TAP): a multi-center survey to evaluate the percentages of dyslipidemic patients receiving lipid-lowering therapy and achieving low-density lipoprotein cholesterol goals 显示文摘	Pearson TA Laurora I Chu H	2000	Arch Intern Med2000，160，4：	1
6	Smart grid cyber security for Europe显示文摘	Pearson I L G	2011	Energy Policy2011，39，9：	1
7	Diet, fecal water, and colon cancer - development of a biomarker 显示文摘	PEARSON J R GILL C I R ROWLAND I R	2009	Nutr Rev2009，67，9：	1
8	Bacterial antimutagenesis by hydroxycinnamic acids from plant cell walls 显示文摘	Ferguson L R Lim I F Pearson A E	2003	Mutat Res2003，542，：	1
9	The lipid treatment assessment project(L-TAP):a multicenter survey to evaluate the percentages of dyslipidemic patients receiving lipid-lowering therapy and achieving low-density lipoprotein cholesterol goals显示文摘	Pearson TA Laurora I Chu H	2000	Arch Intern Med2000，160，：	1
10	Scaling properties inlandscape patterns:New Zealand experience显示文摘	NIKORA V I PEARSON C P SHANKAR U	1999	Landscape Ecology1999，14，1：	1
11	Evidence of nerve sheath differentiation and high grade morphology in sclerosing epithelioid fibrosarcoma显示文摘	Hanson I M Pearson J M Eyden B P	2001	J Clin Pathol2001，54，：	1
12	Rancidity and wamed- over flavour显示文摘	Gray J I Pearson 'A M	1987	Adv Maat Rese1987，3，：	1
13	Stress tolerance in intertidal seaweeds显示文摘	Davison I R Pearson G A	1996	J Phycol1996，32，：	1
14	Effects of synthetic antioxidants (BHA,BHT and PG) on the mutagenicity of IQ-like compounds显示文摘	Chen C Pearson A M Gray J I		0，，：	1
15	Variability in radiocarbon ages of individual organic compounds from marine sediments显示文摘	Eglinton T I Benitez-Nelson B C Pearson A	1997	Science1997，277，5327：	1
16	The origin of n-alkanes in Santa Monica Basin suri'ace sediment: a model based on compound-specific A14C & δ13C data 显示文摘	Pearson A Eglinton T I	2000	Organic Geochemistry2000，31，：	1
17	Particulate matter accumulation on horizontal surfaces in interiors:influence of foliage plants显示文摘	Lohr V I Pearson Mims C H	1996	Atmospheric Environment1996，30，14：	1
18	Development of a large-scale chemogenomics database to improve drug candidate selection and to tmderstand mechanisms of chemical toxicity and action显示文摘	GANTER B TUGENDREICH S PEARSON C I	2005	J Biotechnol2005，119，3：	1
19	Rancidity and warmed-over flavour显示文摘	Gray J I Pearson A M	1987	Adv Meat Rese1987，，3：	1
20	Self-pierce riveting for sheetmaterials:State of the art 显示文摘	He X C Pearson I Young K	2008	J Mater Processing Technol2008，199，13：	1

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