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| 1 | Ehealth:Low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome显示文摘AIM:To investigate the effects of a low fermentable,oligosaccharides,disaccharides,monosaccharides and polyols diet(LFD)and the probiotic Lactobacillus rhamnosus GG(LGG)in irritable bowel syndrome(IBS).METHODS:Randomised,unblinded controlled trial on the effect of 6-wk treatment with LFD,LGG or a normal Danish/Western diet(ND)in patients with IBS fulfilling Rome III diagnostic criteria,recruited betweenNovember 2009 and April 2013.Patients were required to complete on a weekly basis the IBS severity score system(IBS-SSS)and IBS quality of life(IBS-QOL)questionnaires in a specially developed IBS web selfmonitoring application.We investigated whether LFD or LGG could reduce IBS-SSS and improve QOL in IBS patients.RESULTS:One hundred twenty-three(median age 37years,range:18-74 years),90(73%)females were randomised:42 to LFD,41 to LGG and 40 to ND.A significant reduction in mean±SD of IBS-SSS from baseline to week 6 between LFD vs LGG vs ND was revealed:133±122 vs 68±107,133±122 vs 34±95,P<0.01.Adjusted changes of IBS-SSS for baseline covariates showed statistically significant reduction of IBS-SSS in LFD group compared to ND(IBS-SSS score75;95%CI:24-126,P<0.01),but not in LGG compared to ND(IBS-SSS score 32;95%CI:18-80,P=0.20).IBS-QOL was not altered significantly in any of the three groups:mean±SD in LFD 8±18 vs LGG 7±17,LFD 8±18 vs ND 0.1±15,P=0.13.CONCLUSION:LFD is efficacious for patients with IBS. | Natalia Pedersen Nynne Nyboe Andersen Zsuzsanna Végh Lisbeth Jensen Dorit Vedel Ankersen Maria Felding Mette Hestetun Simonsen Johan Burisch Pia Munkholm | 2014 | World Journal of Gastroenterology2014，20，43： | 16 |
| 2 | Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease显示文摘AIM To investigate the effect of a low-FODMAP diet on irritable bowel syndrome(IBS)-like symptoms in patients with inflammatory bowel disease(IBD).METHODS This was a randomised controlled open-label trial of patients with IBD in remission or with mild-to-moderate disease and coexisting IBS-like symptoms(Rome III) randomly assigned to a Low-FODMAP diet(LFD) or a normal diet(ND) for 6 wk between June 2012 andDecember 2013. Patients completed the IBS symptom severity system(IBS-SSS) and short IBD quality of life questionnaire(SIBDQ) at weeks 0 and 6. The primary end-point was response rates(at least 50-point reduction) in IBS-SSS at week 6 between groups; secondary end-point was the impact on quality of life. RESULTS Eighty-nine patients, 67(75%) women, median age 40, range 20-70 years were randomised: 44 to LFD group and 45 to ND, from which 78 patients completed the study period and were included in the final analysis(37 LFD and 41 ND). There was a significantly larger proportion of responders in the LFD group(n = 30, 81%) than in the ND group(n = 19, 46%);(OR = 5.30; 95%CI: 1.81-15.55, P < 0.01). At week 6, the LFD group showed a significantly lower median IBSSSS(median 115; inter-quartile range [IQR] 33-169) than ND group(median 170, IQR 91-288), P = 0.02. Furthermore, the LFD group had a significantly greater increase in SIBDQ(median 60, IQR 51-65) than the ND group(median 50, IQR 39-60), P < 0.01.CONCLUSION In a prospective study, a low-FODMAP diet reduced IBS-like symptoms and increased quality of life in patients with IBD in remission. | Natalia Pedersen Dorit Vedel Ankersen Maria Felding Henrik Wachmann Zsuzsanna Végh Line Molzen Johan Burisch Jens Rikardt Andersen Pia Munkholm | 2017 | World Journal of Gastroenterology2017，23，18： | 15 |
| 3 | Follow-up of patients with functional bowel symptoms treated with a low FODMAP diet显示文摘AIM: To investigate patient-reported outcomes from, and adherence to, a low FODMAP diet among patients suffering from irritable bowel syndrome and inflammatory bowel disease.METHODS: Consecutive patients with irritable bowel syndrome(IBS) or inflammatory bowel disease(IBD) and co-existing IBS fulfilling the ROME Ⅲ criteria, who previously attended an outpatient clinic for low FODMAP diet(LFD) dietary management and assessment by a gastroenterologist, were invited to participate in a retrospective questionnaire analysis. The questionnaires were sent and returned by regular mail and gathered information on recall of dietarytreatment, efficacy, symptoms, adherence, satisfaction, change in disease course and stool type, and quality of life. Before study enrolment all patients had to sign an informed written consent.RESULTS: One hundred and eighty patients were included, 131(73%) IBS and 49(27%) IBD patients. Median age was 43 years(range: 18-85) and 147(82%) were females. Median follow-up time was 16 mo(range: 2-80). Eighty-six percent reported either partial(54%) or full(32%) efficacy with greatest improvement of bloating(82%) and abdominal pain(71%). The proportion of patients with full efficacy tended to be greater in the IBD group than in the IBS group(42% vs 29%, P = 0.08). There was a significant reduction in patients with a chronic continuous disease course in both the IBS group(25%, P < 0.001) and IBD group(23%, P = 0.002) along with a significant increase in patients with a mild indolent disease course of 37%(P < 0.001) and 23%(P = 0.002), respectively. The proportion of patients having normal stools increased with 41% in the IBS group(P < 0.001) and 66% in the IBD group(P < 0.001). One-third of patients adhered to the diet and high adherence was associated with longer duration of dietary course(P < 0.001). Satisfaction with dietary management was seen in 83(70%) IBS patients and 24(55%) IBD patients. Eightyfour percent of patients lived on a modified LFD, where some foods rich in FODMAPs were reintroduced, and 16% followed the LFD by the book without deviations. Wheat, dairy products, and onions were the foods most often not reintroduced by patients.CONCLUSION: These data suggest that a diet low in FODMAPs is an efficacious treatment solution in the management of functional bowel symptoms for IBS and IBD patients. | Louise Maagaard Dorit V Ankersen Zsuzsanna Végh Johan Burisch Lisbeth Jensen Natalia Pedersen Pia Munkholm | 2016 | World Journal of Gastroenterology2016，22，15： | 8 |
| 4 | Methods for the extraction and RNA profiling of exosomes显示文摘AIM:To develop protocols for isolation of exosomes and characterization of their RNA content.METHODS:Exosomes were extracted from He La cell culture media and human blood serum using the Total exosome isolation(from cell culture media)reagent,and Total exosome isolation(from serum)reagent respectively.Identity and purity of the exosomes was confirmed by Nanosight?analysis,electron microscopy,and Western blots for CD63 marker.Exosomal RNA cargo was recovered with the Total exosome RNA and protein isolation kit.Finally,RNA was profiled using Bioanalyzer and quantitative reverse transcriptionpolymerase chain reaction(q RT-PCR)methodology.RESULTS:Here we describe a novel approach for robust and scalable isolation of exosomes from cell culture media and serum,with subsequent isolation and analysis of RNA residing within these vesicles.The isolation procedure is completed in a fraction of the time,compared to the current standard protocols utilizing ultracentrifugation,and allows to recover fully intact exosomes in higher yields.Exosomes were found tocontain a very diverse RNA cargo,primarily short sequences 20-200 nt(such as mi RNA and fragments of m RNA),however longer RNA species were detected as well,including full-length 18S and 28S r RNA.CONCLUSION:We have successfully developed a set of reagents and a workflow allowing fast and efficient extraction of exosomes,followed by isolation of RNA and its analysis by q RT-PCR and other techniques. | Emily Zeringer Mu Li Tim Barta Jeoffrey Schageman Ketil Winther Pedersen Axl Neurauter Susan Magdaleno Robert Setterquist Alexander V Vlassov | 2013 | World Journal of Methodology2013，3，1： | 5 |
| 5 | Clinical outcome in children with acute renal failure treated with peritoneal dialysis after surgery for congenital heart disease 显示文摘 | Pedersen K R Hjortdal V E Christensen S | 2008 | Kidney International2008，73，108： | 1 |
| 6 | The optimal dosing regimen for citalopram-Ameta-analysis of nine placebo-controlled studies显示文摘 | MONTGOMERY S A PEDERSEN V TANGH J P | 1994 | Int Clin P Sychopharmacol1994，9，1： | 1 |
| 7 | Randomized clinical trial of the effect of pneumoperitoneum on cardac function and haemodynamics during laparoscopic cholecystectomy显示文摘 | Larsen JF Svendsen FM Pedersen V | | 0，，07： | 1 |
| 8 | Characterization of sediments from Copenhagen Harbour by use of biotests显示文摘 | Pedersen F Bernestad E Andersen H V | 1998 | Water Science and Technology1998，37，67： | 1 |
| 9 | Development and validation of a magnetic resonance imaging reference criterion for defining a positive sacroiliac joint magnetic resonance imaging in spondyloarthritis显示文摘 | Weber U Zubler V Pedersen S J | 2013 | Arthritis Care Res (Hoboken)2013，65，6： | 1 |
| 10 | Identification of a novel structural protein of arterivimses 显示文摘 | Snijder E J Tol H V Pedersen K W | 1999 | J Virol1999，73，8： | 1 |
| 11 | Expression of a naturallyoccurring constitutively active variant of the epidermal growth factorreceptor in mouse fibroblasts increases motility 显示文摘 | Pedersen MW Tkach V Pedersen N | 2004 | Int J Cancer2004，108，5： | 1 |
| 12 | Asset pricing with liquidity risk 显示文摘 | Acharya V V and Pedersen L H | 2005 | Journal of Financial Economics2005，77，2： | 1 |
| 13 | Asset pricing with liq- uidity risk显示文摘 | Acharya V V Pedersen L H | 2005 | Journal of Financial Economics2005，77，2： | 1 |
| 14 | Neural cell ad hesion molecule-stimulated neurite outgrowth depends on acti- vation o protein kinase C and the Ras-mitogen-aetivated pro- tein kinase pathway显示文摘 | Kolkova K Novitskaya V Pedersen N | 2000 | J Neurosci2000，20，6： | 1 |
| 15 | Characterization of sediments from Copenhagen harbor by use of biotests显示文摘 | PEDERSEN F SJOBROESTAD E ANDERSEN H V | 1998 | Water Sci Technol1998，37，6： | 1 |
| 16 | Single-dose pharmacokinetics of citalopram patients with moderate renal insufficiency or hepatic cirrhosis compared with healthy subjects 显示文摘 | JOFFE P LARSEN FS PEDERSEN V | 1998 | Eur J Clin Pharmacol1998，54，3： | 1 |
| 17 | Postterm delivery and risk for epilepsy in childhood显示文摘 | Ehrenstein V Pedersen L Holsteen V | 2007 | Pediatrics2007，119，3： | 1 |
| 18 | Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury 显示文摘 | Simonen M Pedersen V Schwab ME | 2003 | Neuron2003，38，2： | 1 |
| 19 | Development and validation of a magnetic resonance imaging reference criterion for defining apositive sacroiliac joint magnetic resonance imaging finding in spondyloarthritis 显示文摘 | Weber U Zubler V Pedersen SJ | 2013 | Arthritis Care Res (Hoboken)2013，65，6： | 1 |
| 20 | Randomized clinical trial of the effect of pneumoperitoneum on cardiac function and haemodynamics during laparoscopic cholecystectomy显示文摘 | Svendsen FM Pedersen V | 2004 | Br J Surg2004，91，7： | 1 |
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