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| 1 | Optimal length of triple therapy for H pylori eradication in a population with high prevalence of infection in Chile显示文摘AIM:To compare the efficacy of 7-d versus 14-d triple therapy for the treatment of H pylori infection in Chile,with a prevalence of 73% in general population. METHODS:H pylori-infected patients diagnosed by rapid urease test,with non-ulcer dyspepsia or peptic ulcer disease were randomized to receive omeprazole 20 mg bid,amoxicillin 1 g bid,and clarithromycin 500 mg bid for 7 (OAC7) or 14 (OAC14) d. Primary outcome was eradication rate 6 wk after the treatment. Subgroup analysis was carried out considering the eradication rate among patients with or without peptic ulcer disease and eradication rate among smokers or non-smokers. RESULTS:One hundred and thirty-one patients were randomized to OAC7 (n = 69) or OAC14 (n = 62). The overall eradication rate (intention-to-treat) was 78.3% in OAC7 and 85.5% in OAC14 groups,without a significant difference (P =0.37). No significant difference in the eradication rate was found among the patients with peptic ulcer disease (n = 31) between the OAC7 group (85.7%) and OAC14 group (87.5%). However,smokers had an obviously lower eradication rate compared to non-smokers,particularly in the OAC7 group (57.1% in smokers vs 83.6% in non-smokers; P = 0.06). Adverse effects rate were similar between both groups. CONCLUSION:Short-term efficacy of triple therapy with OAC for 7 d is comparable to 14 d in this high-prevalence population. Longer follow-up,and studies focused to some subgroups of patients (smokers and non-ulcerpatients) are necessary to support widespread use of 7-d instead of 10-14-d triple therapy in a developing country like Chile. | Arnoldo Riquelme Alejandro Soza Cesar Pedreros Andrea Bustamante Felipe Valenzuela Francisco Otarola Eduardo Abbott Marco Arellano Brenda Medina Alejandro Pattillo Douglas Greig Marco Arrese Antonio Rollan | 2007 | World Journal of Gastroenterology2007，13，21： | 3 |
| 2 | Application of grain size trend analysis for the determination of sediment transport pathways in intertidal areas 显示文摘 | Pedreros R Howa H L Michel D | 1996 | Marine geology1996，135，： | 2 |
| 3 | Influence of polymorphisms and TNF and IL1β serum concentration on the infliximab response in Crohn’s disease and ulcerative colitis显示文摘 | Diana Lacruz-Guzmán Daniel Torres-Moreno Francisco Pedrero Patricia Romero-Cara Iván García-Tercero Javier Trujillo-Santos Pablo Conesa-Zamora | 2013 | European Journal of Clinical Pharmacology2013，，3： | 2 |
| 4 | Application of G1S - Based Multi - Criteria Analysis for Site Selection of Aquifer Recharge with Re- claimed water 显示文摘 | Pedrero F Albuquerque A Marecos do Monte H | 2011 | Resources Conservation and Recycling2011，56，1： | 1 |
| 5 | Application of grain size trend analysis for the determination of sediment transport pathways in intertidal areas显示文摘 | Pedreros R Howa H L Michel D | 1996 | Marine Geology1996，135，： | 1 |
| 6 | Application of a modified geometry of a face gear drive 显示文摘 | Claudio Z Pedrero J I | 2005 | Computer Methods in Applied Mechanics and Engineering2005，194，7： | 1 |
| 7 | Melatonin blocks the activation of estrogen receptor for DNA binding显示文摘 | Rato AG Pedrero JG Martinez M | 1999 | FASEB J1999，13，8： | 1 |
| 8 | Application of grain size trend analysis for the determination of sediment transport pathways in intertidal areas 显示文摘 | Pedreros R Howa H L Michel D | 1996 | Marine Geology1996，135，： | 1 |
| 9 | Attenuation of symbiotic effectiveness by Rhicobium meliloti SAF22 related to the presence of a cryptic plasmid显示文摘 | VELAZQUEZ E MATEOS P F PEDRERO P | 1995 | Appl Environ Microbiol1995，61，： | 1 |
| 10 | Application of modified geometry of face gear drives显示文摘 | Zanzi C Pedrero J I | 2005 | Computer Methods in Applied Mechanics and En- gineering2005，194，272829： | 1 |
| 11 | Applicationof grain size trend analysis for the deermination of sediment transport pathways in intertidal areas显示文摘 | Pedreros R Howa H L Michel D | 1996 | Marine Geology1996，135，： | 1 |
| 12 | Melatonin, an endogenous-specific inhibitor of estrogen receptor alpha via calmod- ulin显示文摘 | Del Rio B Garcia Pedrero JM Martinez Campa C | 2004 | J Biol Chem2004，279，38： | 1 |
| 13 | Melatonin,an endogenous-specific inhibitor of estrogen receptor alpha viacalmodulin显示文摘 | Del Rio B Garcia Pedrero J M Martinez-Campa C | 2004 | J Biol Chem2004，279，38： | 1 |
| 14 | Characterization of Alkanethiol-self-assembled Monolayers-moditied Gold Electrodes by Electrochemical ImpedanceSpectroscopy 显示文摘 | CAMPUZANO S PEDRERO M MONTEMAYOR C | 2006 | Journal of Electroanalytical Chemistry2006，586，1： | 1 |
| 15 | Novel approaches for selenium speciation in foodstuffs and biological specimens: a review 显示文摘 | Pedrero Z Madrid Y | 2009 | Analytica Chimica Acta2009，634，2： | 1 |
| 16 | Weed control during aspara-gus establishment year in a volcanic soil of Chile显示文摘 | PEDREROS A GONZáLEZ MI GUAD-AMUD C | 2002 | Acta Hortic2002，589，： | 1 |
| 17 | Immunosen sor for the determination of Staphylococcus aureus using a tyrosi- nase-mercaptopropionic acid modified electrode as an amperomet- tic transducer显示文摘 | Escamilla Gomez V Campuzano S Pedrero M | 2008 | Anal Bioanal Chem2008，391，3： | 1 |
| 18 | Mobile phone abuse or addiction:A review of the literature显示文摘 | Pedrero Pérez E J Rodríguez Monje M T Ruiz Sánchez De León J M | 2012 | Adicciones2012，24，2： | 1 |
| 19 | Electrochemical genosensors for the detection of cancer-related miRNAs显示文摘 | Campuzano S Pedrero M Pingarr6n JM | 2014 | Anal Bioanal Chem2014，406，1： | 1 |
| 20 | Voltammetric Determination of Antibacterial Nitro-Compounds at Activated Carbon Fiber Microelectrodes显示文摘 | Guzman A Pedrero L A Ynez-Sedeno P | 2004 | Electroanalysis2004，21，16： | 1 |
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