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2246篇 您的检索式:作者名="Pei Zhang"
    题名 作者 年代 出处 被引量
1Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets显示文摘Liver fibrosis is a reversible wound-healing process aimed at maintaining organ integrity, and presents as the critical pre-stage of liver cirrhosis, which will eventually progress to hepatocellular carcinoma in the absence of liver transplantation. Fibrosis generally results from chronic hepatic injury caused by various factors, mainly viral infection, schistosomiasis, and alcoholism; however, the exact pathological mechanisms are still unknown. Although numerous drugs have been shown to have antifibrotic activity in vitro and in animal models, none of these drugs have been shown to be efficacious in the clinic. Importantly, hepatic stellate cells(HSCs) play a key role in the initiation, progression, and regression of liver fibrosis by secreting fibrogenic factors that encourage portal fibrocytes, fibroblasts, and bone marrow-derived myofibroblasts to produce collagen and thereby propagate fibrosis. These cells are subject to intricate cross-talk with adjacent cells, resulting in scarring and subsequent liver damage. Thus, an understanding of the molecular mechanisms of liver fibrosis and their relationships with HSCs is essential for the discovery of new therapeutic targets. This comprehensive review outlines the role of HSCs in liver fibrosis and details novel strategies to suppress HSC activity, thereby providing new insights into potential treatments for liver fibrosis.Chong-Yang Zhang Wei-Gang Yuan Pei He Jia-Hui Lei Chun-Xu Wang 2016World Journal of Gastroenterology2016,22,48:114
2Mianlüe tectonic zone and Mianlüe suture zone on southern margin of Qinling-Dabie orogenic belt显示文摘The Mianle tectonic zone (Mianle zone), an ancient suture zone in addition to the Shangdan suture in the Qinling-Dabie orogenic belt, marks an important tectonic division geo-logically separating north from south and connecting east with west in China continent. To de-termine present structural geometry and kinematics in the Mianle tectonic zone and to recon-struct the formation and evolution history involving plate subduction and collision in the Qinling-Dabie orogenic belt, through a multidisciplinary study, are significant for exploring the mountain-building orogenesis of the central orogenic system and the entire process of the major Chinese continental amalgamation during the Indosinian.ZHANG Guowei1, DONG Yunpeng1, LAI Shaocong1, GUO Anlin1, MENG Qingren2, LIU Shaofeng3, CHENG Shunyou1, YAO Anping1, ZHANG Zongqing4, PEI Xianzhi5 & LI Sanzhong6 1. Department of Geology, Northwest University, Xian 710069, China 2. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100101, China 3. Earth Science and Resource Faculty, China University of Geosciences, Beijing 100083, China 4. Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China 5. Changan University, Xian 710054, China 6. Qingdao University of Oceanography, Qingdao 266003, China 2004Science China Earth Sciences2004,47,4:57
3基于割集功率空间上的静态电压稳定域局部可视化方法显示文摘提出了一种新型快速的割集功率空间上电压稳定域边界局部近似算法,以用于实现静态电压稳定域的可视化。该算法首先在电力系统状态空间上推导出求解电压稳定域边界局部的线性方程组,利用该方程组可快速地求解出状态空间上的一组近似电压稳定域边界点;然后通过潮流方程将边界映射到割集功率空间上,解决了电压稳定域可视化的降维问题。在此基础上,可利用最小二乘法拟合出割集功率空间上的一个超平面,用以近似地表达电压稳定域边界。IEEE118节点系统算例结果表明,该方法能在割集功率空间上以较小的误差快速地近似表达出电压稳定域边界的局部;算法 对于实现电压稳定域的在线计算及可视化具有一定的实用价值。王成山 许晓菲 余贻鑫 魏炜 STEPHEN T.Lee ZHANG Pei 2004中国电机工程学报2004,24,9:41
4电压稳定裕度对参数灵敏度求解的新方法显示文摘针对与鞍结分岔相关的电压稳定裕度对参数的灵敏度计算问题,该文提出了一种解线性方程组求灵敏度的新方法。与以往方法不同的是:该方法无需求解鞍结分岔点处潮流雅可比矩阵零特征值对应的左特征向量,而只需求解一个左端系数阵为扩展潮流雅可比矩阵的线性方程组。由于避免了左特征向量的迭代求解,因此该方法简单实用,计算量小,适于在线静态电压稳定分析的使用。另外文中还对另一种普遍存在的分岔形式——限值诱导分岔的特点与灵敏度计算作了探讨。在EPRI1000母线系统算例下的计算表明,本文方法切实可行并具有较高的精度。江伟 王成山 余贻鑫 ZHANG Pei 2006中国电机工程学报2006,26,2:50
5Permian volcanisms in eastern and southeastern margins of the Jiamusi Massif, northeastern China: zircon U-Pb chronology, geochemistry and its tectonic implications显示文摘LA-ICP-MS zircon U-Pb dating and geochemical data for the Late Paleozoic volcanic rocks from eastern and southeastern margins of the Jiamusi Massif are presented to understand the regional tectonic evolution. Zircons from eight representative volcanic rocks are euhedral-subhedral in shape and dis- play striped absorption and fine-scale oscillatory growth zoning as well as high Th/U ratios (0.33―2.37), implying a magmatic origin. The dating results show that the Late Paleozoic volcanic rocks in the study area can be divided into two stages, i.e., the Early Permian (a weighted mean 206Pb/238U age of 288 Ma) and the Middle Permian volcanisms (a weighted mean 206Pb/238U age of 268 Ma). The former is com- posed mainly of basalt, basaltic-andesite, andesite and minor dacite. They are characterized by low SiO2 contents, high Mg# (0.40―0.59), enrichment in Na (Na2O/K2O = 1.26―4.25) and light rare earth elements (LREEs), relative depletion in heavy rare earth elements (HREEs) and high field strength ele- ments (HFSEs), indicating that an active continental margin setting could exist in the eastern margin of the Jiamusi Massif in the Early Permian. The latter consists mainly of rhyolite and minor dacite with high SiO2 (77.23%―77.52%), low MgO (0.11%―0.14%), enrichment in K2O (Na2O/K2O ratios < 0.80) and Rb, Th, U and depletion in Eu, Sr, P and Ti, implying a crust-derived origin. Therefore, it is proposed that the Middle Permian volcanic rocks could have formed under the collision of the Jiamusi and the Khanka Massifs.MENG En XU WenLiang YANG DeBin PEI FuPing Yu Yang Zhang XingZhou 2008Chinese Science Bulletin2008,53,8:42
6Disposable circumcision suture device: clinical effect and patient satisfaction显示文摘根据我们的经验,经历割礼的病人主要关于疼痛和阴茎外观被担心。我们进行了未来的使随机化的试用估计一台新可处理的割礼缝术设备(DCSD ) 的好处。942 个病人的一个总数同等地被划分成三个组(常规割礼,商戒指和可处理的缝术设备组) 。在 DCSD 组的病人是有化合物 5% lidocaine 乳脂的 anesthetized,其它与 2% lidocaine 阴茎块。操作时间, intra 起作用的血损失,切口愈合时间, intra 起作用、手术后的疼痛,阴茎外观和全面满足度被测量。操作时间和 intra 起作用的血损失与传统的组相比在商戒指和缝术设备组是显著地更低的(P <0.001 ) 。Intra 起作用的疼痛与另外的二个组相比是在缝术设备组的更少(P <0.001 ) ;而手术后的疼痛在与另外的二个组相比的传统的组是更高的(P <0.001 ) 。设备(80.57%) 和商戒指(73.57%) 组织的在缝术的病人是与常规割礼组相比对阴茎外观满意的更多(20.06% , P <0.05 ) 。在缝术设备组的病人也比传统的组快显著地愈合了(P <0.01 ) 。全面满足率在缝术设备组(78.66%) 更好与相比常规(47.13%) 并且商戒指(50.00%) 组(P <0.05 ) 。DCSD 和 lidocaine 乳脂的联合导致了更短的操作和切口愈合时间,减少了 intra 起作用、手术后的疼痛并且改进了对化妆外观的耐心的满足。Bo-Dong Lv Shi-Geng Zhang Xuan-Wen Zhu Jie Zhang Gang Chen Min-Fu Chen Hong-Liang Shen Zai-Jun Pei Zhao-Dian Chen 2014Asian Journal of Andrology2014,16,3:49
7Mesenchymal stem cells derived from human placenta suppress allogeneic umbilical cord blood lymphocyte proliferation显示文摘ABSTRACTHuman placenta-derived mononuclear cells (MNC) were isolated by a Percoll density gradient and cultured in mesen-chymal stem cell (MSC) maintenance medium. The homogenous layer of adherent cells exhibited a typical fibroblast-like morphology, a large expansive potential, and cell cycle characteristics including a subset of quiescent cells. In vitrodifferentiation assays showed the tripotential differentiation capacity of these cells toward adipogenic, osteogenic andchondrogenic lineages. Flow cytometry analyses and immunocytochemistry stain showed that placental MSC was ahomogeneous cell population devoid of hematopoietic cells, which uniformly expressed CD29, CD44, CD73, CD105,CD166, laminin, fibronectin and vimentin while being negative for expression of CD31, CD34, CD45 and α-smoothmuscle actin. Most importantly, immuno-phenotypic analyses demonstrated that these cells expressed class I majorhistocompatibility complex (MHC-I), but they did not express MHC-II molecules. Additionally these cells could sup-press umbilical cord blood (UCB) lymphocytes proliferation induced by cellular or nonspecific mitogenic stimuli. Thisstrongly implies that they may have potential application in allograft transplantation. Since placenta and UCB arehomogeneous, the MSC derived from human placenta can be transplanted combined with hematopoietic stem cells(HSC) from UCB to reduce the potential graft -versus-host disease (GVHD) in recipients.Chang Dong LI Wei Yuan ZHANG He Lian LI Xiao Xia JIANG Yi ZHANG Pei Hsien TANG Ning MAO 2005Cell Research2005,15,7:36
8The Serum Exosome Derived MicroRNA-135a,-193b, and-384 Were Potential Alzheimer's Disease Biomarkers显示文摘Objective MicroR NAs(mi Rs) are attractive molecules to be considered as one of the blood-based biomarkers for neurodegenerative disorders such as Alzheimer's disease(AD). The goal of this study was to explore their potential value as biomarkers for the diagnosis of AD. Methods The expression levels of exosomal miR-135 a,-193 b, and-384 in the serum from mild cognitive impairment(MCI), dementia of Alzheimer-type(DAT), Parkinson's disease with dementia(PDD), and vascular dementia(VaD) patients were measured with a real-time quantitative reverse transcriptase PCR(qR T-PCR) method. Results Both serum exosome mi R-135 a and miR-384 were up-regulated while miR-193 b was down-regulated in serum of AD patients compared with that of normal controls. Exosome miR-384 was the best among the three miR s to discriminate AD, VaD, and PDD. Using the cut-off value could better interpret these laboratory test results than reference intervals in the AD diagnosis. ROC curve showed that the combination of mi R-135 a,-193 b, and-384 was proved to be better than a particular one for early AD diagnosis. Conclusion Our results indicated that the exosomal miR s in the serum were not only potential biomarker of AD early diagnosis, but might also provide novel insights into the screen and prevention of the disease.YANG Ting Ting LIU Chen Geng GAO Shi Chao ZHANG Yi WANG Pei Chang 2018Biomedical and Environmental Sciences2018,31,2:35
9割集功率空间上静态电压稳定域的实用边界显示文摘提出了电力系统在割集功率空间上静态电压稳定域边界的实用表达方法。用临界割集将系统分为地理上互不连通的两部分,即相对集中的弱节点区域和非弱节点区域,利用连续潮流,搜索大量的电压稳定临界点,以临界割集上线路的有功和无功潮流为坐标,并通过最小二乘法,将获得的临界点以超平面的形式拟合出电压稳定域的边界,其误差可满足工程应用的要求。这种方法既达到了使复杂电力系统降维的目的,又方便了运行人员监视系统稳定性。同时,电压稳定域边界以超平面形式表示,为电力系统的在线安全分析、评估和优化提供了简明、方便的解析工具。该方法在IEEE 14节点、IEEE 39节点、IEEE 118节点等系统和EPRI 1000节点系统的算例中得到了很好的验证,均以较小误差满足工程需要。李慧玲 余贻鑫 韩琪 宿吉锋 赵金利 Stephen T LEE Pei ZHANG 2005电力系统自动化2005,29,4:32
10电力系统注入空间静态电压稳定域边界的实用表达式显示文摘电力系统注入空间上的静态电压稳定域(SVSR)是近有效的电压安全监控手段,对其边界的准确表达和快速求取是 SVSR 实用化的重要保证。该文推导了单机单负荷系统 SVSR 边界的解析表达式,在其启发下,通过将系统静态电压稳定临界条件做 Taylor 级数展开,给出了一种注入空间中 SVSR 边界的二次近似解析表达形式;基于模态分析,提出了选择系统关键节点的方法,以实现注入空间的有效降维。最后,通过 IEEE 14 节点、57 节点系统和EPRI 1000 节点测试系统的算例对文中方法的有效性进行了验证,结果表明:当发电与负荷大范围变动时,在不同运行条件下估计注入空间 SVSR 边界的误差均在 3%以下。韩琪 余贻鑫 李慧玲 贾宏杰 李鹏 Stephen T.Lee ZHANG Pei 2005中国电机工程学报2005,25,5:32
11基于本地相量测量的电压失稳指标工作条件分析显示文摘基于同步相量测量装置(PMU)的电压失稳预测(VIP)指标是基于本地相量测量数据进行电压稳定性分析的方法,它利用最小二乘拟合技术来实时跟踪系统的戴维南等值参数。拟合技术的应用条件和静态电压稳定性的物理意义会对这种指标的使用构成一定限制,若输入的采样数据不满足适当的条件,拟合得到的等值模型没有实际意义,可能造成误判。文中剖析了曲线拟合计算戴维南等值参数时出现参数漂移的原因,据此提出了VIP指标的正确工作条件和有效性判据,确保无效的VIP值不会对运行造成误判。根据实际系统运行数据所做的算例验证了该判据的可靠性。赵金利 余贻鑫 ZHANG Pei 2006电力系统自动化2006,30,24:33
12An atomic force microscopy study of coal nanopore structure显示文摘Coal nanopore structure is an important factor in understanding the storage and migration of absorbed gas in coal. A new method for studying coal nanopore structures is proposed. This idea is based on the nano-level resolution of atomic force microscopy, which can be employed to observe the structural features of coal nanopores clearly, conduct quantitative three-dimensional measurements and obtain structural parameters. Analysis results show that coal nanopores are mainly metamorphic pores and intermolecular pores. The metamorphic pores are commonly rounded and elliptical, increasing quantitatively with the coalification degree. The forms of intermolecular pores change markedly. The average pore size of low-rank coal is bigger than high-rank coal, and the number of intermolecular pores decreases as the coal rank increases. Section analysis effectively characterizes the coal pore microstructure, bearing analysis is a vital approach to measure microporosity, and grain analysis can be employed to study the pore size distribution. Atomic force microscopy is a tool for the in-depth research of coal pore microstructure and the coal-bed methane adsorption mechanism.YAO SuPing JIAO Kun ZHANG Ke HU WenXuan DING Hai LI MiaoChun PEI WenMing 2011Chinese Science Bulletin2011,56,25:30
13Geochemistry and regional distribution of ophiolites and associated volcanics in Mianlüe suture, Qinling-Dabie Mountains显示文摘Systematic studies of the ophiolites and associated volcanics stretching more than 1500 km from the Derni-Nanping-Pipasi-Kangxian area in the west to the Qingshuihe area of the south Dabie Mountains in the east indicate the existence of a suture zone (the Mianl黣 suture) and a vanished paleo-ocean basin (the Mianl黣 paleo-ocean basin) in the region. From west to east, ophiolitic mlange associations distribute discontinuously along the suture. Rock assem-blages include ophiolite, island arc and oceanic island rock series. The Mianl黣 paleo-ocean basin experienced its major formation and expending episode during the Carboniferous-Permian period. The finding of the suture zone and the paleo-ocean basin is tectonically significant in timing the collision between the North China-Qinling and Yangtze blocks and determining the formation and evolution of the Qinling orogenic belt.LAI Shaocong, ZHANG Guowei, DONG Yunpeng, PEI Xianzhi & CHEN Liang Key Laboratory of Continental Dynamics, Ministry of Education and Department of Geology, Northwest University, Xian 710069, China 2004Science China Earth Sciences2004,47,4:25
14Direct generation of ES-like cells from unmodified mouse embryonic fibroblasts by Oct4/Sox2/Myc/KIf4显示文摘Dajiang Qin Wen Li Jin Zhang Duanqing Pei 2007Cell Research2007,17,11:26
15Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4显示文摘最近的尖铁 glycoprotein (S) 鉴别中东呼吸症候群 coronavirus (MERS-CoV ) 指向细胞的受体, dipeptidyl peptidase 4 (DPP4 ) 。顺序比较和当模特儿的分析在病毒的尖铁上揭示了一个通常认为的受体绑定领域(RBD ) ,它调停这个相互作用。我们报导 3.0 Å MERS-CoV RBD 的决定水晶结构跳了到人的 DPP4 的细胞外的领域。我们的结果证明 MERS-CoV RBD 由一个核心和受体绑定子域组成。受体绑定子域与 DPP4 β 交往;推进器然而并非它的内在的 hydrolase 领域。MERS-CoV RBD 和相关 SARS-CoV RBD 分享他们的核心子域的结构的类似的高度,但是在受体绑定子域是尤其是分叉的。Mutagenesis 研究在为到 DPP4 和入口的病毒的绑定是批评的进目标房间的受体绑定子域识别了几关键残余。在在 MERS-CoV RBD 和 DPP4 之间的接口的原子细节提供病毒和受体相互作用的结构的理解,它能对 MERS-CoV 感染指导治疗学和疫苗的开发。Nianshuang Wang Xuanling Shi Liwei Jiang Senyan Zhang Dongli Wang Pei Tong Dongxing Guo Lili Fu Ye Cui Xi Liu Kelly C Arledge Ying-Hua Chen Linqi Zhang Xinquan Wang 2013Cell Research2013,23,8:26
16Relationship between vascular invasion and microvessel density and micrometastasis显示文摘瞄准:在血评估在脉管的侵略和织物和微转移的微容器密度(MVD ) 之间的关系。方法:脉管的侵略被苏木精并且曙红染色并且 immunohistochemiscal 染色检测。没有脉管的侵略,血样品与脉管的侵略和 29 个病人从 17 个病人被收集并且由反向的 transcriptase 聚合酶为 cytokeratin20 (CK20 ) 检验了表示链反应(RT-PCR ) 分析。织物样品的 Microvessel 密度被免疫组织化学也用抗体决定到 CD105。结果:没有脉管的侵略, CK20 与脉管的侵略并且在 29 个病人中的 9 个在 17 个病人中的 12 个被检测。积极 RT-PCR 显著地与脉管的侵略被相关(70.6% 对 30.0% , P < 0.05 ) 。平均 MVD 比在有否定脉管的侵略的病人在有积极脉管的侵略的病人是显著地更高的(29.2 +/- 3.3 对 25.4 +/- 4.7, P < 0.05 ) 。检测, hematoxylin 曙红染色的脉管的侵略是不到那与免疫组织化学的染色。在二染色法之间有有效差量(19.6% 对 36.9% , P < 0.05 ) 。结论:积极 CK20 RT-PCR,肿瘤侵略的深度,淋巴节点地位,转移和 MVD 显著地与脉管的侵略被相关。染色的 Immunohistochemical 比为检测脉管的侵略染色的 hematoxylin 曙红更敏感。Yan-Dong Wang Pei Wu Jia-Ding Mao He Huang Fan Zhang 2007World Journal of Gastroenterology2007,13,46:24
17Northernmost paleo-tethyan oceanic basin in Tibet:Geo-chronological evidence from ^(40)Ar/^(39)Ar age dating of Dur'ngoi ophiolite显示文摘Whole rock 40Ar/39Ar age dating has been conducted on a basalt sample from Dur’ngoi ophiolite, Qinghai Province, which was reported to be the northernmost pa-leo-tethyan oceanic basin in Tibet. A high temperature pla-teau age (345.3±7.9 Ma) with an isochorn age (336.6±7.1 Ma) has been obtained, representing the eruption time of oceanic crust Considering related geological settings, the new age provides constraints on the northernmost pa-leo-tethyan suture zone in Tibet and the tectonic evolution of Paleo-tethys in Northeast Tibet and adjacent areas.CHEN Liang, SUN Yong, PEI Xianzhi, GAO Ming, FENG Tao, ZHANG Zhongqing & CHEN Wen1. Laboratory of Continental Dynamics, Northwest University, Xi’an 710069, China 2. Department of Geology, Northwest University, Xi’an, 710069, China 3. Institute of Geology, Chinese Academy of Geological Sciences, Beijing, 100037, China 2001Chinese Science Bulletin2001,46,14:24
18静态电压稳定域边界的非线性近似解析表达显示文摘在电力系统控制决策与运行分析中,对系统稳定运行区域的边界面几何形状的认识具有重要的意义。文中对注入功率空间中静态电压稳定域边界面(即潮流可解域边界)的二次特性进行了深入的探讨。通过对潮流方程雅可比矩阵的行列式在临界点附近进行泰勒级数展开并保留二次项,得到了计及非线性项的边界近似解析表达式。在计算过程中应用了潮流方程特征值和特征向量灵敏度系数的计算。该方法的优点是算法本身不涉及任何非线性方程的迭代求解,且所提出的非线性解析表达式能在大范围内较好地逼近真实稳定域边界。通过IEEE系统的算例对所提出的方法的精确性进行了验证。韩琪 余贻鑫 贾宏杰 李鹏 Stephen T LEE Pei ZHANG 2005电力系统自动化2005,29,11:22
19Effect of three interventional bronchoscopic methods on tracheal stenosis and the formation of granulation tissues in dogs显示文摘为繁的使成粒状纸巾的形成引起的气管的狭窄的背景治疗学的途径通常包括 electrocautery,机械膨胀,激光治疗,氩血浆凝结(APC ) ,冷冻疗法和 stent 放置。然而,在 stent 插入以后的狭窄仍然是重要限制。我们检验了三条不同途径的功效,包括机械损害的正式就职, APC 与不同力量或持续时间和冷冻疗法表现了,识别限制了使成粒状织物的形成的方法。12 特殊饲养了研究杂种狗的方法被划分成三个组。在组 1 (四条狗) 温和(过程 1;二条狗) 或中等(过程 2;二条狗) 损坏机械地被导致。(六条狗) 组 2 在不同力量或持续时间收到了 APC (过程 3:30 W, 1 amis;过程 4:30 W, 2 cm/s;过程 5:25 W, 3 cm/s ) 。(二条狗) 组 3 收到了冷冻疗法(过程 6:30 秒的二个结冰融化周期) 。揭开的自我可扩充的金属性的 stents 在所有狗被插入维持连续刺激到气管 mucosa。狗被监视因为在使用的使成粒状织物增长和方法之间的 4 个星期和关系被分析。在组 1 的结果,使成粒状织物生长与更多的严重机械损坏增加了。在组 2 的使成粒状织物的生长比在组 1 更显著,并且因为严重狭窄,在过程 3 的两条狗死了。在这个组,使成粒状织物的形成与减少的力量和持续时间减少了。在组 3,没有明显的使成粒状织物在星期 4 点被发现。从外国身体(stent ) 的结论损害和刺激是导致使成粒状组织的增生的二个重要因素。热损害例如 APC,似乎导致更大的使成粒状织物生长和软骨损坏与相比机械并且冷冻疗法损害。在有机械膨胀的联合的冷冻疗法可以是为管理使成粒状织物的形成引起的气管的狭窄的一个安全、有效的处理方法。ZHANG Jie WANG Ting WANG Juan PEI Ying-hua XU Min WANG Yu-ling ZHANG Xia WANG Chen 2010Chinese Medical Journal2010,,5:23
20Phase I trial of icotinib, a novel epidermal growth factor receptor tyrosine kinase inhibitor, in Chinese patients with non-small cell lung cancer显示文摘WANG Hart-ping ZHANG Li WANG Yin-xiang TAN Fen-lai XIA Ying REN Guan-jun HU Pei JIANG Ji WANG Meng-zhao XIAO Yi 2011Chinese Medical Journal2011,,13:23
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