3篇
您的检索式：作者名="Peidang Liu"
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| 1 | Inhibition of ROS elevation and damage to mitochondrial function prevents lead-induced neurotoxic effects on structures and functions of AFD neurons in Caenorhabditis elegans显示文摘Here we investigated the possible roles of oxidative stress in the formation of decreased thermotaxis to cultivation temperature in lead(Pb)-exposed nematodes Caenorhabditis elagans.Exposure to Pb at the examined concentrations decreased thermotaxis behaviors,and induced severe deficits in the structural properties of AFD sensory neurons.Meanwhile,Pb exposure caused the induction of severe oxidative damage,reactive oxygen species(ROS) production,and mitochondrial dysfunction in young adults.Moreover,pre-treatment with the antioxidants dimethyl sulfoxide(DMSO),ascorbate and N-acetyl-L-cysteine(NAC),used to inhibit both the ROS elevation and the mitochondrial dysfunction caused by Pb exposure,at the L2-larval stage prevented the induction of oxidative damage and the formation of severe deficits in thermotaxis and structural properties of AFD sensory neurons in Pb-exposed young adults.Therefore,the formation of oxidative stress caused by Pb exposure may be due to both the induction of ROS elevation and damage to mitochondrial function,and oxidative stress may play a key role in inducing the neurotoxic effects on the structures and function of AFD sensory neurons in Pb-exposed nematodes. | Qiuli Wu Peidang Liu Yinxia Li Min Du Xiaojuan Xing Dayong Wang | 2012 | Journal of Environmental Sciences2012，24，4： | 3 |
| 2 | Association of oxidative stress with the formation of reproductive toxicity from mercury exposure on hermaphrodite nematode Caenorhabditis elegans 显示文摘 | WU Qiuli HE Kewen LIU Peidang | 2011 | Environmental Toxicology and Pharmacology2011，32，2： | 1 |
| 3 | Exposure to mercury causes formation of male-specific structural deficits by inducing oxidative damage in nematodes 显示文摘 | LIU Peidang HE Kewen LI Yinxia | 2012 | Ecotoxicology and Environmental Safety2012，79，： | 1 |
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