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| 1 | Humanized mice are susceptible to Salmonella typhi infection显示文摘Salmonella enterica serovar Typhi is a pathogen that only infects humans.Currently,there is no animal model for studying this pathogen.Recently,alymphoid RAG2^(-/-)/γc^(-/-) mice engrafted with human leukocytes,known as humanized mice,have been successfully utilized to develop experimental models for several human-specific viral infections,including HIV,human-like dengue fever and hepatitis C virus.Little is known about the usefulness and feasibility of the humanized mouse model for the study of human-specific bacterial pathogens,such as S.typhi.The aim of this study was to determine if Salmonella enterica serovar Typhi could establish productive infection in humanized mice.Here we report that intravenous inoculation of S.typhi into humanized mice,but not controls,established S.typhi infections.High bacterial loads were found in the liver,spleen,blood and bone marrow of mice reconstituted with human leukocytes,but not in the unreconstituted control mice.Importantly,S.typhi-infected humanized mice lost significant body weight,and some of the infected mice displayed neurological symptoms.Our data suggest,for the first time,that humanized mice are susceptible to S.typhi challenge and that this model can be utilized to study the pathogenesis of S.typhito develop novel therapeutic strategies. | M Firoz Mian Elisabeth A Pek Meghan J Chenoweth Ali A Ashkar | 2011 | Cellular & Molecular Immunology2011，8，1： | 2 |
| 2 | Diabetes mellitus and inpairedglucose tolearan in patient with schizophrenia显示文摘 | Subramaniam M Chong SA Pek E | 2003 | Can J Psychiat2003，48，5： | 1 |
| 3 | Effects of sulfur dioxide,hydrogen peroxide and sulfuric acid on the de novo synthesis ofPCDD/F and PCB under model laboratory conditions 显示文摘 | Pekárek V Pun?ochá? M Bure? M | 2007 | Chemosphere2007，66，10： | 1 |
| 4 | Diabetes mellitus and impaired glucose tolerance in patient with schizophrenia 显示文摘 | Subramaniam M chong SA and PEK E | 2003 | Canadian Journal of Psychiatry2003，48，： | 1 |
| 5 | Diabetes mellitus and impaired glucose tolerance in patients with schizophrenia显示文摘 | Subramaniam M Chong SA Pek E | 2003 | Can J Psychiatry2003，48，5： | 1 |
| 6 | Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells显示文摘 | Vejrazka M Mícek R Stípek S | | 0，，： | 1 |
| 7 | Diabetes mellitus and impaired glucose tolerance in patient with schizophrenia 显示文摘 | Subramaniam M Chong SA Pek E | 2003 | Can J of Psychiatry2003，48，： | 1 |
| 8 | Magnetotelluric inversion for anisotropic conductivities in layered media显示文摘 | Pek J Santos F A M | 2006 | Physics of the Earth and Planetary Interiors2006，158，24： | 1 |
| 9 | The experiences of loneliness depression and social support of Turkish patients with continuous ambulatory peritoneal dialysis and their care显示文摘 | A sti T Kara M pek G | 2006 | J Clin Nurs2006，15，4： | 1 |
| 10 | Diabetes mellitus and im paired glucose tolerance in patient with schizophrenia 显示文摘 | Subramaniam M Chong SA Pek E | 2003 | Can J Psychiatry2003，48，5： | 1 |
| 11 | Diabetes melitus and impaired glucose tolerance in patients with schizophrenia 显示文摘 | Subramaniam M Chong SA Pek E | 2003 | Can J Psychiatry2003，48，5： | 1 |
| 12 | Role for adenosine in channel arrest in the anoxic t urtle brain显示文摘 | Lutz PL | 1996 | J Exp Biol1996，200，： | 1 |
| 13 | Prevention of insulitis and diabetes onset by treatment with complete Freund's adjuvant in NOD mice显示文摘 | Pek S B Thomas D W | 1991 | Diabetes1991，40，6： | 1 |
| 14 | Six GTP-binding proteins of the Era/Obg family are essential for cell growth in Bacillus subtilis显示文摘 | Takuya M Pek C Tomohiro H | 2002 | Microbiology2002，148，： | 1 |
| 15 | Bringing responsibility for small area variations in hospi- talization rates back to the hospital: the propen- sity to hospitalize index and a test of the Roeer' s Law显示文摘 | Shwartz M Pek? z EA | 2011 | Med Care2011，49，12： | 1 |
| 16 | Porous collagen-apatite nanocomposite foams as bone regeneration scarf olds显示文摘 | Pek Y S Gao S Arshad M S | 2008 | Biomaterials2008，29，43： | 1 |
| 17 | Open hearts build lives: positive emotions,induced through loving - kindness meditation,build consequential personal resources显示文摘 | Fredrickson Barbara L Michael a Cohn Kimberly a Coffey Jolynn Pek Sandra M Finkel | | 0，，05： | 1 |
| 18 | Diabetes mellitus and impaired glucose tolerance in patient with schizophrenia显示文摘 | Subramaniam M Chong SA Pek E | 2003 | Can J of Psychiatry2003，48，4： | 1 |
| 19 | The impact of genetic removal of GFAP and/or vimentin on glutamine levels and transport of glucose and ascorbate in astrocytes显示文摘 | PeK ny M Eliasson C Siushansian R | 1999 | Neurochem Res1999，24，： | 1 |
| 20 | Brain Na^+/K^+-ATPase activity in two anoxia tolerant vertebrates: erucian carp and freshwater turtle 显示文摘 | Hylland P Milton S Pek M | 1997 | Neuroscienee Letters1997，235，12： | 1 |
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