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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | High Content of Fly Ash (class F) in Extruded Cementitious Composites显示文摘 | Peled A Cyr M F Shah S P | 2000 | ACI material Journal2000，，： | 1 |
| 3 | Mierostructural development of human newborn cerebral white matter assessed in vivo by diffusion tensor magnetic resonance imaging显示文摘 | Huppi P S Maier S E Peled S | 1998 | Pediatr Res1998，44，4： | 1 |
| 4 | A steady state,one dimensional,model for boiling two phase-flow in triangular micro-channel显示文摘 | Peles Y P Haber S | 2000 | International Journal of Multiphase Flow2000，26，7： | 1 |
| 5 | Mortality in sleep apnea patients:a multivariate analysis of risk factors显示文摘 | Lavie P Herer P Peled R | 1995 | Sleep1995，18，3： | 1 |
| 6 | Altered brain glucose metabolism in transgenic-PFKL mice with elevated L phospho{ructokinase: in vivo NMR studies 显示文摘 | Peled Kamar M Degani H Bendel P | 1998 | Brain Res1998，810，： | 1 |
| 7 | Mortality in sleep apnea patients: a multivariate analysis of risk factors显示文摘 | Lavie P Herer P Peled R | 1995 | Sleep1995，18，3： | 1 |
| 8 | A Steady State, One Dimensional, Model for Boiling Two Phase Flow in Triangular Micro- Channel 显示文摘 | Peles Y P Haber S | 2000 | Int J of Multiphase Flow2000，26，7： | 1 |
| 9 | The use of alloplas- tic materials in rhinoplasty surgery: a meta-analysis 显示文摘 | Peled ZM Warren AG Johnston P | 2008 | Plast Reconstr Surg2008，121，3： | 1 |
| 10 | Mortality in sleep apnea patients显示文摘 | Lavie P Herer P Peled R | 1995 | Sleep1995，18，3： | 1 |
| 11 | Mortality in sleep apnea patients: a multivariate analysis of risk factors 显示文摘 | Lavie P Herer P Peled R | 1995 | Sleep1995，18，3： | 1 |
| 12 | Conditional and specific NF-kB blockade protects pancreatic beta cells from diabetogenic agents显示文摘 | Eldor R Yeffet A Baum K Doviner V Amar D Ben-neriah Y Christofori G Peled A Carel J C Boitard C Klein T Serup P Eizirik D L Melloul D | 2006 | Proceedings of the National Academy of Sciences of the United States of America2006，103，： | 1 |
| 13 | Parameters Related to Fiber Length and Processing in Cementitious Composites 显示文摘 | Akkaya Y Peled A Shah S P | 2000 | Materials and Structures2000，33，： | 1 |
| 14 | Mortality in sleep apnea patients: a multivariate analysis of risk of factors 显示文摘 | Here P Peled R | 1995 | Sleep1995，18，： | 1 |
| 15 | A steady state,one dimension-al,model for boiling two phase flow in triangular mi-cro-channel显示文摘 | Peles Y P Haber S | 2000 | International Journal of MultiphaseFlow2000，26，7： | 1 |
| 16 | Parameter related to fiber length and processing in cementitious composites显示文摘 | Akkaya Y Peled A Shah S P | 2000 | Material and Structure2000，10，33： | 1 |
| 17 | High content of fly ash(Class F) in extruded cementitious composites显示文摘 | Cyr M Shah S P | 2000 | ACI Materials Journal2000，97，5： | 1 |
| 18 | Smartly designed phuln- reactive silica nanoparlicles and their reactivity显示文摘 | PELED A NADDAKA M LELLOUCHE J P | 2011 | Journal of Materi- als Chemistry2011，21，11： | 1 |
| 19 | Influence of hydrodynamics and diffusion upon the stability limits of laminar premixed flames显示文摘 | Pelee P Clavinp | 1982 | Journal of Fluid Mechanism1982，124，： | 1 |
| 20 | High content of fly ash (class F) in extruded cementitious composites显示文摘 | Peled A Cyr M F Shah S P | 2000 | ACI Materials Journal2000，97，5： | 1 |
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