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| 1 | Different profile of cytokine synthesis according to the severity of acute pancreatitis显示文摘AIM: To evaluate the cellular synthetic ability of cytokines involved in pro- and anti-inflammatory reactions in patients with AP.METHODS: Sixty-seven patients with AP (16 severe,51 mild) and 10 controls were included in the study.Cultures of whole blood were performed in samples obtained within the first 72 h from the onset of pain.Serum levels of interleukins (IL) 6, 8, 10, and TNF-α were measured at baseline and in the supernatant of cultures with (functional reserve) or without stimulation with phytohemaglutinin.RESULTS: Basal levels of cytokines were significantly higher in patients with severe AP. A significant increase of all pro-inflammatory cytokines vs basal levels was observed in the supernatant after 24 h of whole blood cultures in patients, but not in controls. In contrast, IL-10 increased significantly in the supernatant of cultures only in patients with mild AP. Cells showed a statistically significant functional reserve for all IL in patients with mild, but only for pro-inflammatory cytokines in patients with severe AP.CONCLUSION: A marked activation of immune system may be observed in patients with AP, being balanced between pro- and anti-inflammatory cytokines in patients with mild but not severe AP. A reduced functional reserve for the synthesis of IL-10 may be observed in patients with severe AP, which might lead to a worst prognosis. | Raquel Laveda Juan Martínez Carlos Mu■oz Juan Carlos Penalva Jesus Sáez Germán Belda Salvador Navarro Faust Feu Anton Mas José Ma Palazón José Sánchez-Payá José Such Miguel Pérez-Mateo | 2005 | World Journal of Gastroenterology2005，11，34： | 24 |
| 2 | International NeuroAIDS: prospects of HIV-1 associated neurological com-plications显示文摘Neurological complications associated with HIV-1/AIDS are being recognized with a high frequency that parallels the increased number of AIDS cases. The early infiltration by HIV-1 into the nervous system can cause primary and/or secondary neurological complications. The most common neurocognitive disorder is AIDS Dementia Complex (ADC). In developing countries of Asia the three most opportunistic infections are tuberculosis (TB), cryptococcosis, and Pneumocystis carinii pneumonia. Therefore, it is expected that secondary neurological complications due to TB and cryptococcosis will be the most common cause of morbility and mortality in HIV-1/AIDS cases in China. Research of NeuroAIDS in China is necessary to understand the impact and the biology of HIV-1 in the nervous system. Future studies would include, the molecular epidemiology and the description of opportunistic infections associated to HIV-1; the neuropathological description of primary and secondary HIV-1 complications in different groups; the HIV-1 neurot- ropism and immune response studies for China’s unique HIV-1 strains and recombinant forms derived from the nervous system, including experimental models such as the use of transgenic rats; and the study of potential resistant virus, primarily when the anti-retroviral therapy (ART) has not full access in the brain. | J Roberto TRUJILLO Gilberto JARAMILLO-RANGEL Marta ORTEGA-MARTINEZ Augusto C PENALVA de OLIVEIRA Jose E VIDAL Joseph BRYANT Robert C GALLO | 2005 | Cell Research2005，15，11： | 4 |
| 3 | Accounting Conservatism and Corporate Governance 显示文摘 | Lara J Osma B Penalva F | 2009 | Review of Accounting Studies2009，14，1： | 1 |
| 4 | Tool wear detection in dry high-speed milling based upon the analysis of machine internal signals 显示文摘 | RIVERO A DE LACALLE L N L PENALVA M L | 2008 | Mechatronics2008，18，10： | 1 |
| 5 | Mi- eroRNA- 16 and MicroRNA- 424 regulate cell -autonomous anglo- genie functions in endothelial cells via tm'geting vascular endothelial growth factor receptor -2 and fibroblast factor receptor - 1 显示文摘 | CHAMORRO JORGANES A ARALDI E PENALVA L O | 2011 | Arte- rioscler Thromb Vase Biol2011，31，11： | 1 |
| 6 | Accounting Conservatism and Corporate Governance显示文摘 | Lara J M Osma B G Penalva F | 2009 | Review of Accounting Studies2009，14，： | 1 |
| 7 | Analytical Properties of Im-munosensors Working in Organic Media显示文摘 | Penalva J Puchades R Maquieira A | 1999 | Anal Chem1999，71，17： | 1 |
| 8 | Accounting conservatism and corporate governance显示文摘 | Juan Manuel García Lara Beatriz García Osma Fernando Penalva | 2009 | Review of Accounting Studies2009，，1： | 1 |
| 9 | Immunosensor for trace determination of Irgarol 1051 in seawater using organic media 显示文摘 | Penalva J Gonzalez-Martinez M A Puchades R | 1999 | Analytica Chimica Acta1999，387，3： | 1 |
| 10 | Musashi1 regulates breast tu-mor cellproliferation and is a prognostic indicator of poor survival显示文摘 | Wang XY Penalva LO Yuan H | | 0，，： | 1 |
| 11 | Global signatures of protein and mRNA expression levels 显示文摘 | de Sousa Abreu R Penalva LO Marcotte EM | 2009 | Mol Biosyst2009，5，12： | 1 |
| 12 | The Economic Determinants of Conditional Conservatism 显示文摘 | Juan Manuel Garcfa Lara Beatriz Garcfa Osma Femando Penalva | 2009 | Journal of Business Finance and Accounting2009，36，4： | 1 |
| 13 | Accounting conservatism and corporate governance 显示文摘 | Juan Manuel Garcia Lara Beatriz Garcia Osma Femando Penalva | 2009 | Rev Account Stud2009，，14： | 1 |
| 14 | Compact UWB bandpass filter based on sig- nal interference technique显示文摘 | Miguel d Sdnchez Soriano E B Germtin torregrosa- penalva | 2009 | IEEE Microwave and Wireless Components Letters2009，19，11： | 1 |
| 15 | Regulation of gene expression by ambient pH in filamentous fungi and yeasts 显示文摘 | Penalva M A Arst H M Jr | 2002 | Microbiol Mol Biol Rev2002，66，： | 1 |
| 16 | Recent advances in the characterization of ambient pH regulation of gene expression in filamentous fungi and yeasts 显示文摘 | Penalva M A Arst H N Jr | 2004 | Annual Review of Microbiology2004，58，： | 1 |
| 17 | The Economic determinants of conditional conservatism 显示文摘 | Lara M L G Osma B G Penalva F | 2009 | Journal of Business Finance and Accounting2009，36，34： | 1 |
| 18 | MieroRNA-16 and microRNA-424 regulate cell-autonomous angiogenie funetions in endothelial cells via targeting vascular endothelial growth factor reeeptor-2 and fibroblast growth factor reecptor-1 显示文摘 | Chamorro-Jorganes A Araldi E Penalva LO | 2011 | Arterioseler Thromb Vase Bio12011，31，11： | 1 |
| 19 | Accounting conservatism and corporate governance显示文摘 | Garc i a Lara J M Garcia Osma B Penalva F | 2011 | Review of Accounting Studies2011，14，1： | 1 |
| 20 | MieroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-I 显示文摘 | Chamorro-Jorganes A Araldi E Penalva LO | 2011 | Arlerioscler Thromb Vasc Biol2011，31，11： | 1 |
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