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| 1 | Pediatric primary urolithiasis: Symptoms, medical management and prevention strategies显示文摘In the past few decades pediatric urolithiasis has become more frequent. The reason for this increase is not completely clear but has been attributed to changes in climate, nutritional habits and possibly other environmental factors. Although less frequent than adult stone disease, urolithiasis in the pediatric age group is also related to significant morbidity, particularly since stones tend to recur, and, thus, should not be underestimated. Most children with idiopathic stone disease have an underlying metabolic abnormality substantiating the importance of metabolic evaluation already following initial diagnosis of urolithiasis. Identification of the metabolic abnormality allows for more specific prescription of non pharmacological and pharmacological interventions aimed at preventing recurrent stone formation. A better understanding of the causes of kidney stone disease will provide better strategies for stone prevention in children. | Maria Goretti Moreira Guimar?es Penido Marcelo de Sousa Tavares | 2015 | World Journal of Nephrology2015，4，4： | 4 |
| 2 | Parathyroid ultrasonography and bone metabolic profile of patients on dialysis with hyperparathyroidism显示文摘AIM To evaluate the parathyroid ultrasonography and define parameters that can predict poor response to treatment in patients with secondary hyperparathyroidism due to renal failure.METHODS This cohort study evaluated 85 patients with chronic kidney disease stage V with parathyroid hormone levels above 800 pg/mL. All patients underwent ultrasonography of the parathyroids and the following parameters were analyzed: Demographic characteristics(etiology of chronic kidney disease, gender, age, dialysis vintage, vascular access, use of vitamin D), laboratory(calcium, phosphorus, parathyroid hormone, alkaline phosphatase, bone alkaline phosphatase), and the occurrence of bone changes, cardiovascular events and death. The χ~2 test were used to compare proportions or the Fisher exact test for small sample frequencies. Student t-test was used to detect differences between the two groups regarding continuous variables.RESULTS Fifty-three patients(66.4%) had parathyroid nodules with higher levels of parathyroid hormone, calcium and phosphorus. Sixteen patients underwent parathyroidectomy and had higher levels of phosphorus and calcium × phosphorus product(P = 0.03 and P = 0.006, respectively). They also had lower mortality(32% vs 68%, P = 0.01) and lower incidence of cardiovascular or cerebrovascular events(27% vs 73%, P = 0.02). Calcium × phosphorus product above 55 mg^2/dL^2 [RR 1.48(1.06, 2.08), P = 0.03], presence of vascular calcification [1.33(1.01, 1.76), P = 0.015] and previous occurrence of vascular events [RR 2.25(1.27, 3.98), P < 0.001] were risk factors for mortality in this population. There was no association between the occurrence of nodules and mortality.CONCLUSION The identification of nodules at ultrasonography strengthens the indication for parathyroidectomy in patients with secondary hyperparathyroidism due to renal failure. | Cláudia Ribeiro Maria Goretti Moreira Guimaraes Penido Milena Maria Moreira Guimaraes Marcelo de Sousa Tavares Bruno das Neves Souza Anderson Ferreira Leite Leonardo Martins Caldeira de Deus Lucas Joséde Campos Machado | 2016 | World Journal of Nephrology2016，5，5： | 2 |
| 3 | Clinical, etiological and progression factors of hearing in sudden deafness显示文摘 | Penido Nde O Ramos HV Barros FA | 2005 | Braz J Otorhinolaryngol2005，71，5： | 1 |
| 4 | Clinical, etiological and progression factors of hearing in sudden deafness 显示文摘 | Penido Nde O Ramos HV Barros FA | 2005 | Braz J Otorhinolaryngol2005，71，5： | 1 |
| 5 | Phosphate homeostasis and its role in bone health显示文摘 | Penido MG Alon US | | 0，，： | 1 |
| 6 | Clinical,etiological and progression factors of hearingin sudden deafness显示文摘 | Penido Nde O Ramos HV Barros FA | 2005 | Rev Bras Otorrinolaringol2005，71，5： | 1 |
| 7 | Intracranial complications of otitis media:15 years of experiences in 33 patients显示文摘 | Penido Nde O Borin A Iha LC | 2005 | Otolaryngol Head Neck Surg2005，132，1： | 1 |
| 8 | Clini- cal, etiological and progression factors of hearing in sud- den deafness 显示文摘 | Penido NDO Ramos HVL Barros FA | 2005 | Revista Brasileira de Otorrinolaring ologia2005，71，5： | 1 |
| 9 | Does thiazide treatment improve bone mineral density in hypercalciuric children 显示文摘 | Moreira Guimares Penido MG de Sousa Tavares M | 2012 | Pediatr Nephrol2012，27，8： | 1 |
| 10 | Clinical, etiological and progression factors of hearing in sudden deafness 显示文摘 | Penido Nde O Ramos HV Barros FA | 2005 | Rev Bras Otorrinolaringol2005，71，5： | 1 |
| 11 | Remifentanil in neonatal intensive care and anaesthesia practice 显示文摘 | Penido MG Garra R Sammartino M | 2010 | Acta Paediatr2010，99，10： | 1 |
| 12 | Plasma and urinary levels of cytokines in patients with idiopathic hy- percalciuria 显示文摘 | Santos AC Jr Lima EM Penido MG | 2012 | Pediatr Nephrol2012，27，6： | 1 |
| 13 | Clinical, etiological and progression factors of hearing in sudden deafhess显示文摘 | Penido Nde O Ramos HV Barros FA | 2005 | Braz OtotTinolaryngol2005，71，5： | 1 |
| 14 | Hypophosphatemie rickets due to per turbations in renal tubular function显示文摘 | Penido MG Alon US | 2014 | Pediatr Nephrol2014，29，3： | 1 |
| 15 | Plasma and urinary levels of cytokines in patients with idio- pathle hyperealeiuria显示文摘 | Santos A C Jr Lima E M Penido M G | 2012 | Pecliatr Nephrol2012，27，6： | 1 |
| 16 | Bone disease in pediatric idiopathic hypercalciuria显示文摘Idiopathic hypercalciuria(IH) is the leading metabolic risk factor for urolithiasis and affects all age groups without gender or race predominance. IH has a high morbidity with or without lithiasis and reduced bone mineral density(BMD), as described previously in pediatric patients as well as in adults. The pathogenesis of IH is complex and not completely understood, given that urinary excretion of calcium is the end result of an interplay between three organs(gut, bone and kidney), which is further orchestrated by hormones, such as 1,25 dihydroxyvitamin D, parathyroid hormone, calcitonin and fosfatonins(i.e., fibroblast growth-factor-23). Usually, a primary defect in one organ induces compensatory mechanisms in the remaining two organs, such as increased absorption of calcium in the gut secondary to a primary renal loss. Thus, IH is a systemic abnormality of calcium homeostasis with changes in cellular transport of this ion in intestines, kidneys and bones. Reduced BMD has been demonstrated in pediatric patients diagnosed with IH. However, the precise mechanisms of bone loss or failure of adequate bone mass gain are still unknown. The largest accumulation of bone mass occurs during childhood and adolescence, peaking atthe end of the second decade of life. This accumulation should occur without interference to achieve the peak of optimal bone mass. Any interference may be a risk factor for the reduction of bone mass with increased risk of fractures in adulthood. This review will address the pathogenesis of IH and its consequence in bone mass. | Maria Goretti Moreira Guimares Penido Marcelo de Sousa Tavares | 2012 | World Journal of Nephrology2012，1，2： | 1 |
| 17 | Comparisons between the threephase current injection method and the forward/backWard sweep method显示文摘 | Araujo L R D Penido D R R Júnior S C | 2010 | International Journal of Electrical Power & Energy Systems2010，32，7： | 1 |
| 18 | Clinical,etiological and pro- gression factors of hearing in sudden deafness显示文摘 | Penido N de O Ramos HV Barros FA | 2005 | Rev Bras Otor-rinolaringol2005，71，5： | 1 |
| 19 | Cross-priming of long lived protective CD8 + T cells against Trypanosoma cruzi infection : importance of a TLR9 agonist and CD4 + T cells显示文摘 | de Alencar BC Aradjo AF Penido ML | 2007 | Vaccine2007，25，32： | 1 |
| 20 | Schistosomicidal activity of alkylaminooctanethiosulfuric acids显示文摘 | Penido ML Nelson DL Vieira LQ | 1994 | Mem Inst Oswaldo Cruz1994，89，4： | 1 |
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