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| 1 | Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet显示文摘AIM To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS Sprague-Dawley rats were fed with 8% Na Cl highsalt(HS) or 0.4% Na Cl(normal-salt,NS) diet for 3 wk,with or without tempol(T)(1 mmol/L,administered in drinking water). Mean arterial pressure(MAP),glomerularfiltration rate(GFR),and urinary sodium excretion(UVNa) were measured. We evaluated angiotensin Ⅱ(Ang Ⅱ),angiotensin 1-7(Ang 1-7),angiotensin converting enzyme 2(ACE2),mas receptor(Mas R),angiotensin type 1 receptor(AT1R) and angiotensin type 2 receptor(AT2R) in renal tissues by immunohistochemistry.RESULTS The intake of high sodium produced a slight but significant increase in MAP and differentially regulated components of the renal renin-angiotensin system(RAS). This included an increase in Ang Ⅱ and AT1 R,and decrease in ACE-2 staining intensity using immunohistochemistry. Antioxidant supplementation with tempol increased natriuresis and GFR,prevented changes in blood pressure and reversed the imbalance of renal RAS components. This includes a decrease in Ang Ⅱ and AT1 R,as increase in AT2,ACE2,Ang(1-7) and Mas R staining intensity using immunohistochemistry. In addition,the natriuretic effects of tempol were observed in NS-T group,which showed an increased staining intensity of AT2,ACE2,Ang(1-7) and Mas R.CONCLUSION These findings suggest that a high salt diet leads to changes in the homeostasis and balance between opposing components of the renal RAS in hypertension to favour an increase in Ang Ⅱ. Chronic antioxidant supplementation can modulate the balance between the natriuretic and antinatriuretic components of the renal RAS. | Gabriel Cao Silvana Lorena Della Penna Nicolas Martín Kouyoumdzian Marcelo Roberto Choi Susana Gorzalczany Belisario Enrique Fernández Jorge Eduardo Toblli María Inés Roson | 2017 | World Journal of Nephrology2017，6，1： | 4 |
| 2 | Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B:new perspectives for immune therapy显示文摘 | Boni C Penna A Ogg GS | 2001 | Hepatology2001，33，4： | 1 |
| 3 | Radiofrequency thermal ablation of hepatocellular carcinoma liver nodules can activate and enhance tumor-specific T-cell responses显示文摘 | Zerbini A PiUi M Penna A | 2006 | Cancer Res2006，66，： | 1 |
| 4 | Optimization of Nisin Production by Lactococcus lactis 显示文摘 | Penna T C Moraes D A | 2002 | Appl Biochem Biotechnol2002，98，100： | 1 |
| 5 | Determining camera parameters from theperspective projection of a quadrilateral 显示文摘 | PENNA M A | 1991 | PatternRecognition1991，24，6： | 1 |
| 6 | Effect of endothe- lins on the cardiovascular system 显示文摘 | Penna C Rastaldo A Mancardi D | 2012 | J Cardiovasc Med2012，7，9： | 1 |
| 7 | Chronic inflammation in thepathogenesis of benign prostatic hyperplasia显示文摘 | Fibbi B Penna G Morelli A | 2009 | Int J Androl2009，32，8： | 1 |
| 8 | Validation of Ocean Tide Models Around Antarctica Using On- shore GNSS and Gravity Data显示文摘 | King M A Penna N T Clarke P J | 2005 | J Geophys Res- Sol Earth2005，110，08401： | 1 |
| 9 | Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B显示文摘 | Boni C Bertoletti A Penna A | | 0，，： | 1 |
| 10 | Bisphospbonates induce apoptosis of circulating endothelial cells in multiple myeloma patients and in subjects with bisphosphonate-induced osteonecrosis of the jaws显示文摘 | Allegra A Alonci A Penna G | 2010 | Acta Haematol2010，124，2： | 1 |
| 11 | Molecular evolution of plant P5CS gene involved in proline biosynthesis 显示文摘 | RAI A N PENNA S | 2013 | Molecular Biology Reports2013，40，： | 1 |
| 12 | Cooperative spectrum sensing based on the limiting eigenvalue ratio distribution in Wishart matrices显示文摘 | PENNA F GARELLO R SPIRITO M A | | 0，，07： | 1 |
| 13 | Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4 + Foxp3 + regulatory T cells by 1, 25- dihydroxyvitamin D3 显示文摘 | Penna G Roncari A Amuchastegui S | 2005 | Blood2005，106，10： | 1 |
| 14 | Molecular and cellular mechanisms of skeletal muscle atrophy:an update显示文摘 | Fanzani A Conraads VM Penna F | 2012 | J Cachexia Sarcopenia Muscle2012，3，3： | 1 |
| 15 | Chronic inflammation in the pathogenesis of benign prostatic hyperplasia显示文摘 | Fibbi B Penna G Morel i A | | 0，，： | 1 |
| 16 | Evaluation of recombinant green fluorescent protein,under various culture conditions and purification with Hi Trap hydrophobic interaction chromatography resins显示文摘 | PENNA T C V ISHII M JUNIOR A P | | 0，，1： | 1 |
| 17 | Complete response of coloreetal liver metastases after chemotherapy: Does it mean cure? 显示文摘 | Benoist S Brouquet A Penna C | 2006 | J Clin Oncol2006，24，24： | 1 |
| 18 | Predominant T-helper 1cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B显示文摘 | Penna A Del Prete G Cavalli A | 1997 | Hepatology1997，25，4： | 1 |
| 19 | Cytotoxic T lymphocytes recognize an HLA-A2 restricted epitope within the hepatitis B virus nucleocapsid antigen显示文摘 | Penna A Chisari FV Bertoletti A | 1991 | J Exp Med1991，174，6： | 1 |
| 20 | MicroRNA -214 contributes to melanoma tumour progression through suppression of TFAP2C显示文摘 | Penna E Orso F Cimino D Tenag|ia E Lembo A Quaglino E Poliseno L Haimovic A Osella-Abate S De Pitta C Pinatel E Stadler M B Provero P Bemengo M G Osman I Taverna D | 2011 | EMBO Journal2011，30，10： | 1 |
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