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| 1 | Endocrine impact of Helicobacter pylori:Focus on ghrelin and ghrelin o-acyltransferase显示文摘Ghrelin is predominantly produced by the gastric enteroendocrine cell compartment and is octanoylated by the recently discovered ghrelin o-acyltransferase (GOAT) before secretion into the bloodstream. This octanoylation is essential for many of the biological properties of ghrelin including appetite stimulation and anti-inflammatory properties as only the acylated form of ghrelin binds to the ghrelin receptor, the growth hormone secretagogue receptor (GHS-R). Given the gastric location of ghrelin production, it is perhaps not surprising that insult to the gastric mucosa affects circulating ghrelin levels in humans. Helicobacter pylori (H. pylori) infects more than f ifty percent of the world's population and once established within the gastric mucosa, can persist for life. Infection is associated with chronic gastritis, gastric atrophy and ulceration, reduced appetite and a lower body mass index (BMI). The large majority of studies investigating levels of circulating ghrelin and ghrelin expression in the stomach in patients with H. pylori infection indicate that the bacterium has a negative impact on ghrelin production and/or secretion. Eradication of infection restores ghrelin, improves appetite and increases BMI in some studies, however, a causative relationship between H. pylori-associated serum ghrelin decline and food intake and obesity has not been established. Most studies measure total ghrelin in the circulation although the measurement of the ratio of acyl/total ghrelin gives a clearer indication that the ghrelin acylation process is altered during infection and atrophy. GOAT is essential for the production of biologically-active, acyl ghrelin and the impact of H. pylori on GOAT expression and activity will be highly informative in the future. | Penny L Jeffery Michael A McGuckin Sara K Linden | 2011 | World Journal of Gastroenterology2011，17，10： | 12 |
| 2 | Outcomes of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding显示文摘AIM:To evaluate weight loss and surgical outcomes of Roux-en-Y gastric bypass(RYGB)and laparoscopic adjustable gastric band(LAGB).METHODS:Data relating to changes in body mass index(BMI)and procedural complications after RYGB(1995-2009;n=609;116M:493F;42.4±0.4 years)or LAGB(2004-2009;n=686;131M:555F;37.2±0.4years)were extracted from prospective databases.RESULTS:Pre-operative BMI was higher in RYGB than LAGB patients(46.8±7.1 kg/m2vs 40.4±4.2 kg/m2,P<001);more patients with BMI<35 kg/m2underwent LAGB than RYGB(17.1%vs 4.1%,P<0.0001).BMI decrease was greater after RYGB.There were direct relationships between weight loss and pre-operative BMI(P<0.001).Although there was no difference in weight loss between genders during the first 3-year post-surgery,male LAGB patients had greater BMI reduction than females(-8.2±4.3 kg/m2vs-3.9±1.9kg/m2,P=0.02).Peri-operative complications occurred more frequently following RYGB than LAGB(8.0%vs0.5%,P<0.001);majority related to wound infection.LAGB had more long-term complications requiring corrective procedures than RYGB(8.9%vs 2.1%,P<0.001).Conversion to RYGB resulted in greater BMI reduction(-9.5±3.8 kg/m2)compared to removal and replacement of the band(-6.0±3.0 kg/m2).Twelve months post-surgery,fasting glucose,total cholesterol and low density lipoprotein levels were significantly lower with the magnitude of reduction greater in RYGB patients.CONCLUSION:RYGB produces substantially greater weight loss than LAGB.Whilst peri-operative complications are greater after RYGB,long-term complication rate is higher following LAGB. | Nam Q Nguyen Philip Game Justin Bessell Tamara L Debreceni Melissa Neo Carly M Burgstad Pennie Taylor Gary A Wittert | 2013 | World Journal of Gastroenterology2013，19，36： | 3 |
| 3 | Dynamic causal modeling 显示文摘 | Friston K J Harrison L Penny W | 2003 | NeuroImage (S1053-8119)2003，19，4： | 1 |
| 4 | Intravenous sildenafil lowers pulmonary vascular resistance in a modal of neonatal pulmonary hypertension显示文摘 | Shekerdemian L S Ravn I-I B Penny D J | 2002 | Am J Respir Crit Care Med2002，165，8： | 1 |
| 5 | Effect of epistasis on grain yield in maize显示文摘 | Sprague G E Russel W A Penny L H | 1962 | Crop Sci1962，2，： | 1 |
| 6 | Interaction between inhaled nitric oxide and intravenous sildenafil in a porcine model of meconium aspiration syndrome 显示文摘 | Shekerdemian L S Ravn H B Penny D J | 2004 | Pediatr Res2004，55，3： | 1 |
| 7 | Using vibration data and statistical measures to locate damage in structures显示文摘 | Penny J E T Wilsonm D A L | 1994 | Int J Analytical and Experimental Modal Analysis1994，9，4： | 1 |
| 8 | Job stress,incivility,and counter-productive work behavior(CWB):the moderating role of negative affectivity显示文摘 | Penny L M Spector P E | 2005 | Journal of Organizational Behavior2005，26，7： | 1 |
| 9 | Temporal and spatial complexity measures for EEG-based brain-computer interfacing显示文摘 | Roberts SJ Penny W Rezek L | 1998 | Medical and Biological Engineering and Computing1998，37，1： | 1 |
| 10 | The modern molecular clock显示文摘 | Bromham L Penny D | 2003 | Nature Rev Genetics2003，4，： | 1 |
| 11 | Intravenous sildenafil lowers pulmonary vascular resistance in a model of neonatal pulmonary hypertension 显示文摘 | SHEKERDEMIAN L S RAVN H B PENNY D J | 2002 | Am J Respir Crit Care Med2002，165，8： | 1 |
| 12 | Cost effectiveness of a manual based coping strategy programme in promoting the mental health of family carers of people with dementia (the START (STrAtegies for RelaTives) study): a pragmatic randomised controlled trial显示文摘 | Martin Knapp Derek King Renee Romeo Barbara Schehl Julie Barber Mark Griffin Penny Rapaport Debbie Livingston Cath Mummery Zuzana Walker Juanita Hoe Elizabeth L Sampson Claudia Cooper Gill Livingston | 2013 | BMJ (oct )2013，，252： | 1 |
| 13 | Virology,epidemi ology,pathogenesis,and control of enterovirus 71显示文摘 | Tom S Penny L David P | 2010 | Lancet Infect Dis2010，10，3： | 1 |
| 14 | Hyperbaric oxygen for patients with chronic bowel dysfunction after pelvic radiotherapy (HOT2): a randomised, double-blind, sham-controlled phase 3 trial显示文摘 | Mark Glover Gary R Smerdon H Jervoise Andreyev Barbara E Benton Pieter Bothma Oliver Firth Lone Gothard John Harrison Mihaela Ignatescu Gerard Laden Sue Martin Lauren Maynard Des McCann Christine E L Penny Spencer Phillips Grace Sharp John Yarnold | 2016 | The Lancet Oncology2016，，2： | 1 |
| 15 | Intravenous sil- denafil lowers pulmonary vascular resistance in a model of neonmM pulmonary hype-ension 显示文摘 | SHEKERDEMIAN L S RAVN H B PENNY D J | 2012 | Am J Respir Crit Care Med2012，165，8： | 1 |
| 16 | Patterns of injury and recovery in whiplash显示文摘 | PENNIE B AGAMBAR L | 1991 | Injury1991，22，1： | 1 |
| 17 | Investigating individual differences among tar gets of workplace incivility显示文摘 | Milam A C Spitzmueller C and Penny L M | 2009 | Journal of Oc cupational Health Psychology2009，，14： | 1 |
| 18 | Root strength in some Populus and Salix clones显示文摘 | Hathaway R L D Penny | 1975 | New Zealand Journal of Botany1975，13，： | 1 |
| 19 | Clinical features, diagnosis,and management of enterovirus 71 显示文摘 | Mong HO See CW Penny L | 2010 | lancet Neurolog2010，9，11： | 1 |
| 20 | 查看详情显示文摘 | Kurland C G Collins L J Penny D | | 0，，： | 1 |
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