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| 1 | Exposure to polycyclic aromatic hydrocarbons with special focus on cancer显示文摘Polycyclie aromatic hydrocarbons(PAHs) are a group of compounds consisting of two or more fused aromatic rings.Most of them are formed during incomplete combustion of organic materials such as wood and fossil fuels,petroleum products,and coal.The composition of PAH mixtures varies with the source and is also affected by selective weathering effects in the environment.PAHs are ubiquitous pollutants frequently found in a variety of environments such as fresh water and marine sediments,the atmosphere,and ice.Due to their widespread distribution,the environmental pollution due to PAHs has aroused global concern.Many PAHs and their epoxides are highly toxic,mutagenic and/or carcinogenic to microorganisms as well as to higher forms of life including humans.The main aim of this review is to provide contemporary information on PAH sources,route of exposure,worldwide emission rate,and adverse effects on humans,especially with reference to cancer. | Thamaraiselvan Rengarajan Peramaiyan Rajendran Natarajan Nandakumar Boopathy Lokeshkumar Palaniswami Rajendran Ikuo Nishigaki | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，3： | 6 |
| 2 | Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells显示文摘 | Angeline Wei Ling Chua Hui Sin Hay Peramaiyan Rajendran Muthu K. Shanmugam Feng Li Pradeep Bist Evelyn S.C. Koay Lina H.K. Lim Alan Prem Kumar Gautam Sethi | 2010 | Biochemical Pharmacology2010，，10： | 1 |
| 3 | Reduction of mitochondrial oxidative damage and improved mitochondrial efficiency by administration of crocetin against bebzopryene induced experimental animals显示文摘 | Venkatraman M Konga D Peramaiyan R | 2008 | Biol Pham Bull2008，31，9： | 1 |
| 4 | Reduction of mitochondrial oxidative damage and improved mitochondrial efficiency by administration of crocetin against benzo[a] pyrene induced experimental animals显示文摘 | Venkatraman M Konga D Peramaiyan R | | 0，，09： | 1 |
| 5 | Naringenin reduces tumor size and weight lost in N - meth- yl - N'- nitro - N - nitrosoguanidine - induced gastric carcinogenesis in rats 显示文摘 | Ganapathy Ekambaram Peramaiyan Rajendran MAGESH Venkatara- man | 2008 | Nutrition Research2008，28，2： | 1 |
| 6 | Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells显示文摘 | Angeline Wei Ling Chua Hui Sin Hay Peramaiyan Rajendran Muthu K. Shanmugam Feng Li Pradeep Bist Evelyn S.C. Koay Lina H.K. Lim Alan Prem Kumar Gautam Sethi | 2010 | Biochemical Pharmacology2010，，10： | 1 |
| 7 | Free adicalcavenging and antioxidant activity of D-pinitol against 7,12 dimethylbenz(a)anthraceneinduced breast cancer in spraguedawley rats显示文摘 | Thamaraiselvan Rengarajan Peramaiyan Rajendran Natarajan Nandakumar | 2014 | Asian Pac J Trop Dis2014，4，5： | 1 |
| 8 | Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice显示文摘 | Muthu K Peramaiyan Feng L | | 0，，05： | 1 |
| 9 | Diosgenin, a steroidal saponin,inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells 显示文摘 | Feng Li Prasana Priscilla Fernandez Peramaiyan Rajendran et al | 2010 | Cancer Letters2010，292，2： | 1 |
| 10 | Fucoxanthin suppresses OxLDL-induced inflammation via activation of Nrf2 and inhibition of NF-κB signaling显示文摘Objective:To explore the impact of fucoxanthin on oxidized low-density lipoprotein(OxLDL)-induced stress and inflammation in human endothelial cells and its underlying mechanisms.Methods:HUVECs were treated with OxLDL and/or fucoxanthin for a range of time points and concentrations.We evaluated the effects of fucoxanthin on OxLDL-induced HUVECs using the MTT assay,reactive oxygen species accumulation assay,ELISA,RT-PCR,immunofluorescence,and Western blotting.Results:Fucoxanthin enhanced the cell viability in a dose dependent manner after OxLDL exposure.Furthermore,fucoxanthin pretreatment significantly decreased OxLDL-induced reactive oxygen species production and prevented the activation of the nuclear factor kappa-B pathway,which led to substantial suppression of pro-inflammatory gene expressions.OxLDL-induced upregulation of interleukin-6,intercellular adhesion molecule-1,vascular cell adhesion molecule-1,interleukin-1β,monocyte chemotactic protein-1,cyclooxygenase-1,and tumor necrosis factor-αwas significantly reduced by fucoxanthin.Conclusions:Fucoxanthin can inhibit OxLDL-induced vascular inflammation and oxidative stress in HUVECs by targeting Nrf2 signaling pathways. | Peramaiyan Rajendran Abdullah M AlZahrani | 2022 | Asian Pacific Journal of Tropical Biomedicine2022，12，5： | 1 |
| 11 | Reduction of mitochondrial oxidative damage and improved mitochondrial ef- ficiency by administration of crocetin againstbenzo pyrene induced experimental animals 显示文摘 | Venkatraman M Konga D Peramaiyan R | 2008 | Bial Pharm Bull2008，31，9： | 1 |
| 12 | Crystal growth, structural, thermal, optical and laser damage threshold studies of 8 - hydroxyquinolinium hydrogen maleate single crystals 显示文摘 | Peramaiyan G Pandi P Vijayan N | 2013 | J Cryst Growth2013，375，： | 1 |
| 13 | Naringe- nin reduces tumor size and weight lost in N-methyl-N'-nitro-N-ni- trosoguanidine-induced gastric carcinogenesis in rats 显示文摘 | Ganapathy E Peramaiyan R Venkataraman E | 2008 | Nutr Res2008，28，2： | 1 |
| 14 | Garcinol suppresses the growth of human hepatocellular carcinoma by inducing abrogation of STAT3 phosphorylation,acetylation and dimerization显示文摘OBJECTIVE Hepatocellular carcinoma(HCC)is the fifth most common malignancy worldwide and the third cause of global cancer mortality.Activation of signal transducer and activator of transcription 3(STAT3)is commonly observed in tumor cells and is a critical mediator of on cogenic signaling in HCC and controls the expression of several genes involved in proliferation,survival,metastasis and angiogenesis.Current drug-targeted therapies,besides being expensive,are associated with serious side effects and morbidity.Thus,novel agents that can suppress STAT3 activation have potential for both prevention and treatment of HCC.In the present report,we investigated whether the potent HAT/KAT inhibitor,garcinol,(apolyisoprenylatedbenzophenone),could suppress STAT3 activation in HCC cells and in nude mice model.METHODS The effect of garcinol on HCC cell lines wasdetermined by MTT assay,immunoblotting,DNA binding assays,immuno-fluorescenceand immune-histochemical analysis.The effect of garcinolon the inhibition of tumor growth in vivo was also investigated using HCCxenograft tumor modelin athymic nu/nu mice.RESULTS We found that garcinol could inhibit constitutive STAT3 activation in a dose-and time-dependent manner both by inhibiting STAT3 phosphorylation and acetylation in HCC cells.When investigated for molecular mechanism(s),we found that garcinol interferes with the dimer formation of STAT3 thereby inhibits its nuclear localization.Computational modeling showed that garcinol could bind to the SH2 domain of STAT3 and suppresses its dimerization in vitro.To understand the cellular mechanism(s)of inhibition of STAT3 function by garcinol,we observed that upon inhibition of STAT3 dimerization bygarcinol,STAT3 DNA binding ability gets repressed.The inhibition of STAT3 activation by garcinol led to the suppression of various gene products involved in proliferation,survival,and angiogenesis.Finally,when administered i.p.,garcinol inhibited the growth of human HCC xenograft tumors in athymic nu/nu mice.CONCLUSION Results frominvitroand in vivo studies suggest that garcinol exerts its anti-proliferative and pro-apoptotic effects through suppression of STAT3 signaling cascade in HCC by inhibiting its phosphorylation,acetylation and ultimately dimerization. | Muthu K SHANMUGAM Snehajyoti CHATTERJEE Peramaiyan RAJENDRAN Feng LI Parijat SENAPATI Kwong Fai WONG Alan Prem KUMAR John MLUK Kam Man HUI Gautam SETHI Tapas K KUNDU | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 0 |
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