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| 1 | Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications. | Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns | 2015 | World Journal of Gastroenterology2015，21，17： | 4 |
| 2 | Polyol pathway and osmoregulation in JS1 Schwann cells grown in hyperglycemic and hyperosmotic conditions 显示文摘 | Mizisin AP Li L Perello M | 1996 | Am J Physiol1996，270，39： | 1 |
| 3 | GMPLS control plane network design with resilience guarantees 显示文摘 | RUIZ M PERELLO J VELASCO L | 2011 | Journal of Lightwave Technology2011，29，1： | 1 |
| 4 | Interactions bet_ ween FK506 and rifampicin or erythromycin in paedia_ tric liver transplant recipients显示文摘 | Furlan V Perello L Jacquemin | 1995 | Transplantation1995，59，： | 1 |
| 5 | A survey of seasonal temperatures and vineyard altitude influ- ences on 2 - methoxy -3 - isobutylpyrazine, C13 - norisoprenoids, and the sensory profile of Brazilian Cabernet sauvignon wines 显示文摘 | Falcao L D de Revel G Perello M C | 2007 | Journal of Agricultural and Food Chemistry2007，55，09： | 1 |
| 6 | Diffusion Entropy technique applied to the study of the market activity显示文摘 | Palatella L Perello J Montero M | 2005 | Physica A2005，355，： | 1 |
| 7 | Hu- man exposure to perfluorinated compounds in Catalonia, Spain : contribution of drinking water and fish and shellfish 显示文摘 | Domingo J L Ericson -Jogeten I Perello G | 2012 | Agric Food Chem2012，60，17： | 1 |
| 8 | Study of the thermal decomposition of cinoxacin complexes with Co(Ⅱ) Ni(Ⅱ) Cu(Ⅱ)显示文摘 | Perello L Rosello M I Ortiz R | 1986 | Thermochim Acta1986，106，： | 1 |
| 9 | Antibacterial studies,DNA oxidative cleavage, and crystal structures of Cu(Ⅱ) and Co (Ⅱ) complexes with two quinolone family members,ciprofloxacin and enoxacin 显示文摘 | Jimenez-Garrido N Perello L | 2005 | Inorg Biochem2005，99，： | 1 |
| 10 | Antibacterial studies, DNA oxidative cleavage, and crystal structures of Cu( II ) and Co(II ) complexes with two quinolone family members, ciprofloxacin and enoxacin 显示文摘 | Jimenez-Garrido N Perello L Ortiz R | 2005 | J Inorg Biochem2005，99，3： | 1 |
| 11 | Dyspepsia and irrita ble bowel syndrome after a salmonella gastroenteritis outbreak One year follow - up cohort study显示文摘 | Mearin F Perez Oliveras M Perello A et a l | 2005 | Gastroenterology2005，129，： | 1 |
| 12 | Antibac- terial studies, DNA oxidative cleavage, and crystal struc- tures of Cu( Ⅱ ) and Co( Ⅱ ) complexes with two quin- olone family members, ciprofloxacin and enoxacin显示文摘 | N Jime'nez-Garrido L Perello R Ortiz a | 2005 | J Inorg Biochem2005，99，： | 1 |
| 13 | Antibac- terial studies,DNA oxidative cleavage,and crystal struc- tures of Cu( Ⅱ ) and Co( Ⅱ ) complexes with two quin- olone family members, ciprofloxacin and enoxacin显示文摘 | N Jime'nez-Garrido L Perello R Ortiz a | 2005 | J Inorganic Biochem2005，99，： | 1 |
| 14 | Oxidative DNA cleavage induced by an iron (Ⅲ) flavoooid complex: synthesis, crystal structure and characterization of chlorobis(flavonolato) (methanol) iron(Ⅲ) complex显示文摘 | A MRANI F B A E PERELLO L REAL J A | 2006 | Journal of Inorganic Biochemistry2006，100，： | 1 |
| 15 | Antibacte- rim studies, DNA oxidative cleavage, and crystal struc- tures of Cu(Ⅱ) and Co(II) complexes with two quinolone family members,ciprofloxacin and enoxacin 显示文摘 | N Jime'nez-Garrido L Perello R Ortiza | 2005 | J Inorg Biochem2005，99，： | 1 |
| 16 | Synthesis,structure and biological properties of several binary andternary complexes of copper (II) with ciprofloxacin and1,10 phenanthroline 显示文摘 | J Hernandez-Gil L Perello R Ortiz | 2009 | Polyhedron2009，，28： | 1 |
| 17 | A survey of seasonaltemperatures and vineyard altitude influences on 2-Me-thoxy-3-isobutylpyrazine,C13-Norisoprenoids,and the sen-sory profile of brazilian cabernet sauvignon wines显示文摘 | Falcao L D De Revel G Perello M C | 2007 | J Ag-ric Food Chem2007，55，9： | 1 |
| 18 | Antibacte- rim studies, DNA oxidative cleavage, and crystal struc- tures of Cu(Ⅱ) and Co(Ⅱ) complexes with two quinolone family members,ciprofloxacin and enoxaein 显示文摘 | N Jime'nez-Garrido L Perello R Ortiz a | 2005 | J Inorg Biochem2005，99，： | 1 |
| 19 | Anti- bacterial studies, DNA oxidative cleavage, and crystal structures of Cu( Ⅱ ) and Co( Ⅱ ) complexes with two quinolone family members, ciprofloxacin and enoxacin 显示文摘 | N Jime'nez-Garrido L Perello R Ortiz a | 2005 | Journal of Inorganic Biochemistry2005，99，： | 1 |
| 20 | Cobalt(Ⅱ),nickel(Ⅱ), and copper(Ⅱ) complexes of sulfanilamide derivatives: synthesis, spectroscopic studies, and antibacterial activity,crystal structure of 显示文摘 | BLASCO F PERELLO L LATORRE J | 1996 | J Inorg Biochem1996，61，2： | 1 |
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