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| 1 | The effect of extracts of Selaginella involvens and Selaginella inaequalifolia leaves on poultry pathogens显示文摘Objective:To investigate the antimicrobial activity of some commonly available herbs against poultry pathogens such as Escherichia coli(E.coli) and Pseudomonas species isolated from poultry litter.Methods:The extracts of Selaginella involvens and Selaginella inaequalifolia were tested against E.coli and Pseudomonas isolated from poultry litter by the agar diffusion method.Results:Results indicated that different plant extracts showed inhibitory effects against E.coli(8-13 mm ) and Pseudomonas(6.5-13 mm).The four different extracts of Selaginella involvens and Selaginella inaequalifolia showed similar levels of antimicrobial activity on E.coli. Conclusions:The antimicrobial activities of all the four plant extracts are comparable and their potential as alternatives in the treatment of infections by these microorganisms were present in the poultry litter.Susceptibility testing is conduced on isolates using drugs selected on the basis of their importance to human medicine and use in poultry production. | Haripriya Duraiswamy Selvan Nallaiyan Jeyakumar Nelson Periasamy Rathina samy Marimuthu Johnson Irudayaraj Varaprasadam | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，9： | 8 |
| 2 | Single nucleotide polymorphisms in candidate genes are significantly associated with resistance to Haemonchus contortus infection in goats显示文摘Background: Haemonchosis is a major economic problem in goat production in humid, tropical and subtropical regions. The disease is caused by an abomasal nematode, Haemonchus contortus, which is highly pathogenic in small ruminants. The aim of this study was to identifying single-nucleotide polymorphisms(SNP) that were associated with fecal egg counts(FEC) and could be used as markers to identify resistance to H. contortus in goats.Results: Ten novel variants in the CI TA, ATP2 A3, HSPA8, STAT5 B, ESYT1, and SERPING1 genes were associated with FEC in goats with a nominal significance level of P < 0.05. Two missense mutation in the exon region of the caprine CI TA gene resulted in replacement of arginine with cysteine at position 9473550(R9473550 C) and aspartic acid with glutamic acid at position 9473870(D9473870 E). Chinese goat breeds had significantly higher FEC than Bangladeshi goat breeds within their respective genotypes. Polymorphism information content(PIC), effective al ele number(Ne), and heterozygosity(He)were greatest for the STAT5 B197A > G SNP locus in al goat breeds. Pairwise coefficients of linkage disequilibrium(D′, r2)revealed complete LD(r2= 1) between significant SNP polymorphisms in CI TA and SERPING1 and strong LD(r2= 0.93 and0.98) between polymorphisms in HSPA8 and ATP2 A3, respectively. Correlation coefficient(r) between FEC and body weight(BW) was significantly positive(r = 0.56***, P < 0.001) but that between FEC and packed cel volume(PCV) was negatively significant(r =-0.47**, P < 0.01) in the total population of goats. On the other hand, correlation coefficient(r)between BW and PCV was not significant in total population of goats. Association analysis revealed that haplotypes within ATP2 A3, HSPA8, and SERPING1 were significantly associated with FEC. Quantitative real-time PCR revealed that the relative expression of m RNA was higher(P < 0.001) for resistant, compared to susceptible, groups of goats for al candidate genes except CI TA.Conclusions: This study identified SNP markers that can potential y be used in marker-assisted selection programs to develop goat breeds that are resistant to H. contortus. | Mahmuda Bilkis Bintee Alam Abdullah Ibne Omar Md.Omar Faruque David Russell Notter Kathiravan Periasamy Md.Motahar Hussain Mondal Md.Jalal Uddin Sarder Md.Shamsuddin Jianhua Cao Xiaoyong Du Zhenyang Wu Shuhong Zhao | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 2 |
| 3 | Antidiabetic Activity of Ethanolic Extract of Zaleya decandra in Alloxan-Induced Diabetic Rats显示文摘 | Periasamy Meenakshi Rajendran Bhuvaneshwari Muthaiyan Ahalliya Rathi Lakshmanan Thirumoorthi Dugganaboyana Chinna Guravaiah Muthedath Janardhanan Jiji Velliyur Kanniappan Gopalakrishnan | 2010 | Applied Biochemistry and Biotechnology2010，，4： | 2 |
| 4 | Protein localization in living cells and tissues using FRET and FLIM显示文摘 | Chen Y Mills JD Periasamy A | 2003 | Differentiation2003，，910： | 2 |
| 5 | Sarcolipin and phospholamban as regulators of cardiac sarcoplasmic reticulum Ca^2+ ATPase显示文摘 | Bhupathy P Babu GJ Periasamy M | 2007 | J Mol Cell Cardiol2007，42，5： | 1 |
| 6 | Growth and differentiation of smooth muscle cells during vascular development 显示文摘 | Katoh Y Periasamy M | 1996 | Trends Cardiovasc Med1996，6，： | 1 |
| 7 | Clinical exome sequencing facilitates the understanding of genetic heterogeneity in Leber congenital amaurosis patients with variable phenotype in southern India显示文摘Background:Leber congenital amaurosis(LCA),primarily characterized by retinal degeneration is the most severe form of inherited retinal dystrophy(IRD)responsible for congenital blindness.The presence of phenotypic heterogeneity makes the diagnosis of LCA challenging,especially in the absence of pronounced disease pathognomonic,yet it can be well comprehended by employing molecular diagnosis.Therefore,the present study aimed to reveal the causative mutations in ten LCA patients with variable phenotypes using clinical exome sequencing(CES).Methods:CES was performed in ten unrelated LCA patients.Ophthalmic information and family history of all patients were obtained to make a meaningful interpretation.The clinical exome data was analyzed and prioritized using a bioinformatics pipeline to identify mutations,which was further validated by Sanger sequencing.Segregation analysis was also performed on available family members.Results:CES led to the identification of causative mutations in nine LCA patients.Seven patients harbored a mutation in six LCA candidate genes,including RPE65,LCA5(n=2),CRX,PRPH2,CEP290,and ALMS1,while two patients possess a mutation in IFT80 and RP1,known to cause other diseases.Three novel mutations in LCA5(c.1823del),CRX(c.848del)and CEP290(c.2483G>T)were identified.The current study reports for the first time,a mutation in PRPH2,CEP290,and ALMS1 from the Indian population.Additionally,we observed a novel association of LCA phenotype with IFT80 known to cause Jeune syndrome.Based on the genetic finding,the patient AS09,who harbored a mutation in the RP1 gene,was re-diagnosed with early-onset retinitis pigmentosa.Conclusion:In conclusion,the results underline the importance of CES in clinically diagnosed LCA patients with variable phenotypes.The correlation between mutations in candidate genes and clinical phenotypes,helps to refine the clinical diagnosis.However,molecular evaluation with a larger cohort of LCA patients is needed for better understanding of the mutational spectrum in southern India. | Sriee Viswarubhiny Rupa Anjanamurthy Ayyasamy Vanniarajan Devarajan Bharanidharan Vijayalakshmi Perumalsamy Periasamy Sundaresan | 2021 | Eye and Vision2021，8，1： | 1 |
| 8 | Effect of aluminium doping on structural and optoelectronic properties of sol- gel derived nanocrystalline ZnO thin film 显示文摘 | Chakravarty R Periasamy C | 2011 | Science of Advanced Materials2011，3，2： | 1 |
| 9 | Methods of enhancement of reactivity and selectivity of sodium borohydride for applications in organic synthesis显示文摘 | Periasamy M Thirumalaikumar M | 2000 | Journal of Organometallic Chemistry2000，609，1： | 1 |
| 10 | Regulation of sarcoplasmic reticulum Ca2+ ATPase pump expression and its relevance to cardiac muscle physiology and pathology显示文摘 | Periasamy M Bhupathy P Babu GJ | 2008 | Cardiovasc Res2008，77，2： | 1 |
| 11 | Targeting calcium transport in isehaemic heart disease显示文摘 | Hassan Talukder M A Zweier J L Periasamy M | 2009 | Car Res2009，84，3： | 1 |
| 12 | NKG2D-dependent IL-17 production by human T cells in response to an intracellular pathogen显示文摘 | Paidipally P Periasamy S Barnes PF | 2009 | J Immunol2009，1183，3： | 1 |
| 13 | Regulation of sarcoplasmic reticulum Ca2+ ATPase pump expression and its relevance to cardiac muscle physiology and pathology显示文摘 | Periasamy M Bhupathy P Babul GJ | | 0，，02： | 1 |
| 14 | Oxidation of aryl methyl sulfoxides by oxo(salen)manganese(V) complexes and the reactivity-selectivity principle显示文摘 | Arunachalam C Periasamy K | 1999 | J Org Chem1999，64，： | 1 |
| 15 | A convenient method for the oxidation of polycyclic aromatic hydrocarbons to quinones 显示文摘 | PERIASAMY M BHATT M V | 1977 | Synthesis1977，，5： | 1 |
| 16 | Sarcoplasmie Reticulum Gene Expressionin Cardiac Hypertrophy and Heart Failure显示文摘 | Arai M Matsui H Periasamy M | 1994 | Circ Res1994，74，： | 1 |
| 17 | Differential regulation of antioxidant enzymes in response to oxidants 显示文摘 | Schull S Hemtz N Periasamy M | 1991 | Biol Chem1991，266，24： | 1 |
| 18 | The Photoluminescence Properties of Zinc Oxide Nanofibres Prepared by Electrospinning 显示文摘 | Periasamy Viswanathamurthi | 2004 | Nanotechnology2004，，15： | 1 |
| 19 | Targeting calcium transport in ischaemic heart disease显示文摘 | Talukder MA Zweier JL Periasamy M | 2009 | Cardiovasc Res2009，84，3： | 1 |
| 20 | Targeting calcium transport in ischaemic heart disease显示文摘 | Talukder MA Zweier JL Periasamy M | 2009 | Cardiovaac Res2009，84，3： | 1 |
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