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| 1 | Stem cell signaling as a target for novel drug discovery: recent progress in the WNT and Hedgehog pathways显示文摘在在过去几年的生物医学的研究的最令人激动的领域之一是干细胞的干细胞生物学,和治疗学的申请代替 diseased 或损坏纸巾也是在开发的一个活跃区域。尽管干细胞治疗有很多技术挑战和规章的障碍克服,在药发现的工具由成熟技术支持了并且建立了规章的路径的干细胞的使用被期望产生更立即的回来。特别地,指向表明小径的干细胞为药发现正在开创一条新大街。在这些小径的错误导致各种各样的疾病,包括癌症,纤维变性和退化疾病。在表明小径的干细胞的很多个药目标被识别了。在他们之中, WNT 和刺猬是二条很重要的发信号小径,它是这评论的焦点。一个刺猬小径禁止者, vismodegib (Erivedge ) ,最近被 US 食物及药品管理局为皮癌症的治疗同意了,当 WNT 小径的几个药候选人正在进入临床的试用时。我们发现了表明小径的干细胞对繁体中文药作出回应。从草药的药孤立的物质可以对与高亲密关系表明小径的干细胞的部件明确地起作用。当许多能通过分子的相互作用这些事件被解释,这些现象建议从自然产品的指向房间的药可以证明高度成功的茎的那发现。 | Songzhu Michael AN Qiang Peter DING Ling-song LI | 2013 | Acta Pharmacologica Sinica2013，34，6： | 5 |
| 2 | Mars Ion and Neutral Particle Analyzer (MINPA) for Chinese Mars Exploration Mission (Tianwen-1): Design and ground calibration显示文摘The main objective of the Mars Ion and Neutral Particle Analyzer(MINPA)aboard the Chinese Mars Exploration Mission(Tianwen-1)is to study the solar wind-Mars interaction by measuring the ions and energetic neutral atoms(ENAs)near Mars.The MINPA integrates ion and ENA measurements into one sensor head,sharing the same electronics box.The MINPA utilizes a standard toroidal top-hat electrostatic analyzer(ESA)followed by a time of flight(TOF)unit to provide measurement of ions with energies from 2.8 eV to 25.9 keV and ENAs from 50 eV to 3 keV with a base time resolution of 4 seconds.Highly polished silicon single crystal substrates with an Al2O3 film coating are used to ionize the ENAs into positive ions.These ions can then be analyzed by the ESA and TOF,to determine the energy and masses of the ENAs.The MINPA provides a 360°×90°field of view(FOV)with 22.5°×5.4°angular resolution for ion measurement,and a 360°×9.7°FOV with 22.5°×9.7°angular resolution for ENA measurement.The TOF unit combines a-15 kV acceleration high voltage with ultra-thin carbon foils to resolve H+,He2+,He+,O+,O2+and CO2+for ion measurement and to resolve H and O(≥16 amu group)for ENA measurement.Here we present the design principle and describe our ground calibration of the MINPA. | LingGao Kong AiBing Zhang Zhen Tian XiangZhi Zheng WenJing Wang Bin Liu Peter Wurz Daniele Piazza Adrian Etter Bin Su YaYa An JianJing Ding WenYa Li Yong Liu Lei Li YiRen Li Xu Tan YueQiang Sun | 2020 | Earth and Planetary Physics2020，4，4： | 4 |
| 3 | Role of observation of live cases done by Japanese experts in the acquisition of ESD skills by a western endoscopist显示文摘AIM:To evaluate the role of observation of experts performing endoscopic submucosal dissection(ESD)in the acquisition of ESD skills.METHODS:This prospective study is documenting the learning curve of one Western endoscopist.The study consisted of three periods.In the first period(preobservation),the trainee performed ESDs in animal models in his home institution in the United States.The second period(observation)consisted of visit to Japan and observation of live ESD cases done by experts.The observation of cases occurred over a 5-wk period.During the third period(post-observation),the trainee performed ESD in animal models in a similar fashion as in the first period.Three animal models were used:live40-50 kg Yorkshire pig,explanted pig stomach model,and explanted pig rectum model.The outcomes from the ESDs done in the animal models before and after observation of live human cases(main study intervention)were compared.Statistical analysis of the data included:Fisher’s exact test to compare distributions of a categorical variable,Wilcoxon rank sum test to compare distributions of a continuous variable between the two groups(pre-observation and post-observation),and Kruskal-Wallis test to evaluate the impact of lesion location and type of model(ex-vivo vs live pig)on lesion removal time.RESULTS:The trainee performed 38 ESDs in animal model(29 pre-observation/9 post-observation).The removal times post-observation were significantly shorter than those pre-observation(32.7±15.0 min vs 63.5±9.8 min,P<0.001).To minimize the impact of improving physician skill,the 9 lesions post-observation were compared to the last 9 lesions pre-observation and the removal times remained significantly shorter(32.7±15.0 min vs 61.0±7.4 min,P=0.0011).Regression analysis showed that ESD observation significantly reduced removal time when controlling for the sequence of lesion removal(P=0.025).Furthermore,it was also noted a trend towards decrease in failure to remove lesions and decrease in complications after the period of observation.This study did not find a significant difference in the time needed to remove lesions in different animal models.This finding could have important implications in designing training programs due to the substantial difference in cost between live animal and explanted organ models.The main limitation of this study is that it reflects the experience of a single endoscopist.CONCLUSION:Observation of experts performing ESD over short period of time can significantly contribute to the acquisition of ESD skills. | Peter V Draganov Myron Chang Roxana M Coman Mihir S Wagh Qi An Takuji Gotoda | 2014 | World Journal of Gastroenterology2014，20，16： | 3 |
| 4 | A data-driven framework to predict the morphology of interfacial Cu6Sn5 IMC in SAC/Cu system during laser soldering显示文摘A data-driven approach combining together the experimental laser soldering,finite element analysis and machine learning,has been utilized to predict the morphology of interracial intermetallic compound(IMC) in Sn-xAg-yCu/Cu(SAC/Cu) system.Six types of SAC solders with varying weight proportion of Ag and Cu,have been processed with fiber laser at different magnitudes of power(30-50 W) and scan speed(10-240 mm/min),and the resultant IMC morphologies characterized through scanning electron microscope are categorized as prismatic and scalloped ones.For the different alloy composition and laser parameters,finite element method(FEM) is employed to compute the transient distribution of temperature at the interface of solder and substrates.The FEM-generated datasets are supplied to a neural network that predicts the IMC morphology through the quantified values of temperature dependent Jackson parameter(αJ).The numerical value of αJ predicted from neural network is validated with experimental IMC morphologies.The critical scan speed for the morphology transition between prismatic and scalloped IMC is estimated for each solder composition at a given power.Sn-0.7 Cu having the largest critical scan speed at 30 W and Sn-3.5 Ag alloy having the largest critical scan speed at input power values of 40 W and 50 W,thus possessing the greatest likelihood of forming prismatic interfacial IMC during laser soldering,can be inferred as most suitable SAC solders in applications exposed to shear loads. | Anil Kunwar Lili An Jiahui Liu Shengyan Shang Peter Raback Haitao Ma Xueguan Song | 2020 | Journal of Materials Science & Technology2020，47，15： | 3 |
| 5 | Better to be alone than in bad company:The antagonistic effect of cisplatin and crizotinib combination therapy in non-small cell lung cancer显示文摘AIM To investigate the potential benefit of combining the cMET inhibitor crizotinib and cisplatin we performed in vitro combination studies.METHODS We tested three different treatment schemes in four non-small cell lung cancer(NSCLC) cell lines with a different cMET/epidermal growth factor receptor genetic background by means of the sulforhodamine B assay and performed analysis with Calcusyn.RESULTS All treatment schemes showed an antagonistic effect in all cell lines,independent of the cMET status.Despite their different genetic backgrounds,all cell lines(EBC-1,HCC827,H1975 and LUDLU-1) showed antagonistic combination indexes ranging from 1.3-2.7.These results were independent of the treatment schedule.CONCLUSION These results discourage further efforts to combine cMET inhibition with cisplatin chemotherapy in NSCLC. | Nele Van Der Steen Christophe Deben Vanessa Deschoolmeester An Wouters Filip Lardon Christian Rolfo Paul Germonpré Elisa Giovannetti Godefridus J Peters Patrick Pauwels | 2016 | World Journal of Clinical Oncology2016，7，6： | 2 |
| 6 | 低氧血症对心肌声学造影评定冠脉储备的影响显示文摘目的 探讨低氧血症对心肌声学造影 (MCE)评定冠脉储备 (CFR)的影响。方法 对 9只非开胸猪进行心肌 MCE。取乳头肌水平短轴观 ,以 0 .5 ml/ min的速度连续滴注造影剂 Sonovue (BR1 )。每 1 5个心动周期进行一次破泡。破泡后的再充盈时间 -强度关系可用公式 Y=A (1 - e- bt) +c表示 ,依此可得到信号增加率 (b) ,以静息时的 b参数除滴注腺苷后的 b参数所得到的商为 CFR,进行氮气吸入前后的 CFR评定 ,并与荧光微球技术测得的心肌血流及 CFR进行对照。结果 氮气吸入前 2种方法所测得的 CFR相似 ,分别为 2 .5对 3.1 ,氮气吸入使平均氧分压明显降低 ,从 1 2 0 .6降到 5 1 .8mmHg (1 mm Hg=0 .1 33k Pa,下同 ;P<0 .0 0 1 ) ,心率由 1 1 4次 / min增加到 1 1 6次 / min,(P>0 .0 5 )。 CFR也明显降低 ,分别为 1 .5及 2 .5 ,这是由于氮气吸入后静息时的心肌血流轻微增加 ,而腺苷滴注后的心肌血流较氮气吸入前的心肌血流轻度降低所致。结论 氮气吸入导致的低氧血症降低 MCE所评定的 CFR值 ,当应用 MCE评定 CFR时 ,此生理变化的影响必须加以考虑。 | 杨源 李树清 Peters B De Maria AN | 2004 | 中国超声医学杂志2004，20，10： | 2 |
| 7 | Application of the health risk assessment of acetochlor in the development of water quality criteria显示文摘Acetochlor is a widely used herbicide in agricultural production. Studies have shown that acetochlor has obvious environmental hormone effects, and long-term exposure may pose a threat to human health. To quantify the hazards of acetochlor in drinking water, a health risk assessment of acetochlor was conducted in major cities of China based on the data of acetochlor residue concentrations in drinking water. The approach of the Species Sensitivity Distributions(SSD) method is used to extrapolate from animal testing data to reflect worst case human toxicity. Results show that hazard quotients related to acetochlor residues in drinking water for different age groups range from 1.94 × 10-4 to 6.13 × 10-4, so, there are no indication of human risk. Compared to the total estimated hazard quotient from oral intake of acetochlor, the chronic exposure imputed to acetochlor residues in drinking water in China accounts for 0.4%. This paper recommends 0.02 mg/L to be the maximum acetochlor residue concentration level in drinking water and source water criteria. | Wei An Chenhui Sang Kristian Marienlund Jensen Peter Borgen Sørensen Bin Zhang Min Yang | 2021 | Journal of Environmental Sciences2021，33，12： | 2 |
| 8 | Neovascularization in atherectomy specimens from patients with unstable angina: implications for pathogenesis of unstable angina 显示文摘 | Tenaglia AN Peters KG Sketch MH Jr | 1998 | Am Heart J1998，135，1： | 1 |
| 9 | Neovascularization in atherectomy speciments from patients with unstable angina complications from pathogenesis of unstable angina显示文摘 | Tenaglia AN Peters KG Sketch MN | 1998 | Am Heart J1998，135，： | 1 |
| 10 | Roles of endogenous enzymes in surimi gelation显示文摘 | An HJ Peters MY Seymour TA | | 0，，10： | 1 |
| 11 | The electrochemical hydrogenation of edible oils in a solid polymer electrolyte reator Ⅰ: reactor design and operation 显示文摘 | Weidong An Jin Ki Hong Peter N Pintauro | 1998 | Journal of the American Oil Chemists Society1998，75，8： | 1 |
| 12 | Involvement of SSAO-mediated Deamination in Adipose Glucose Transport and Weight Gain in Obesediabetie KKAy Mice 显示文摘 | Peter H Yu Michael Wang Hui I'an | 2004 | Am JPhysiol Endocrinol Metab2004，286，4： | 1 |
| 13 | Neovascularization in atherectomy specimens from patients with unstable angina:implications for pathogenesis of unstable angina显示文摘 | Tenaglia AN Peters KG Sketch MH Jr | 1998 | Am Heart J1998，135，3： | 1 |
| 14 | The electrochemical hydrogenation of edible oils in a solid polymer electrolyte reactor. I. Reactor design and operation显示文摘 | Weidong An Jin Ki Hong Peter N. Pintauro Kathleen Warner William Neff | 1998 | Journal of the American Oil Chemists’ Society1998，，8： | 1 |
| 15 | Inhibitory activity of honey against food borne pathogens as influenced by the presence of hydrogen peroxide and level of antioxidant power显示文摘 | Peter Jr Bradcn AN Larry RB | 2001 | International Journal of Food Microbiology2001，69，3： | 1 |
| 16 | The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study显示文摘 | Guangwei Li Ping Zhang Jinping Wang Edward W Gregg Wenying Yang Qiuhong Gong Hui Li Hongliang Li Yayun Jiang Yali An Ying Shuai Bo Zhang Jingling Zhang Theodore J Thompson Robert B Gerzoff Gojka Roglic Yinghua Hu Peter H Bennett | 2008 | 2008 (9626)2008，，9626： | 1 |
| 17 | Neovascularization in atherectomy specimens from patients with unstable angina:implications for pathogenesis of unstable angina显示文摘 | Tenaglia AN Peters KG Sketch MH Jr | 1998 | Am Heart J1998，135，1： | 1 |
| 18 | Abrasive wear of Al 2 O 3 –SiC and Al 2 O 3 –(SiC)–C composites with micrometer- and submicrometer-sized alumina matrix grains显示文摘 | Jaroslav Sedlá?ek Du?an Galusek Peter ?van?árek Ralf Riedel Alan Atkinson Xin Wang | 2008 | Journal of the European Ceramic Society2008，，15： | 1 |
| 19 | Roles of endogenous enzymes in surimi gelation显示文摘 | An H Peters M Y Seymour T A | 1996 | Trends in Food Science and Technology1996，7，： | 1 |
| 20 | The Ahmed glaucoma valve in neovascular glaucoma ( an aos thesis) 显示文摘 | Peter AN | 2009 | Trans Am Ophthalmol Soc2009，107，9： | 1 |
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