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46篇 您的检索式:作者名="Peter BR"
    题名 作者 年代 出处 被引量
1Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1显示文摘AIM: To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS: The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed using a specialized ultrasound-based probe. Twelve type-1 diabetic patients with autonomic neuropathy and severe gastrointestinal symptoms and 12 healthy controls were studied. The geometry and biomechanical parameters (strain, tension/stress, and stiffness) were assessed. RESULTS: The diabetic patients had increased frequency of distension-induced contractions (6.0 ± 0.6 vs 3.3 ± 0.5, P < 0.001). This increased reactivity was correlated with the duration of the disease (P = 0.009). Impaired coordination of the contractile activity in diabetic patients was demonstrated as imbalance between the time required to evoke the first contraction at the distension site and proximal to it (1.5 ± 0.6 vs 0.5 ± 0.1, P = 0.03). The esophageal wall and especially the mucosa-submucosa layer had increased thickness in the patients (P < 0.001), and the longitudinal and radial compressive stretch was less in diabetics (P <0.001). The esophageal and duodenal wall stiffness and circumferential deformation induced by the distensions were not affected in the patients (all P > 0.14). CONCLUSION: The impaired contractile activity with an imbalance in the distension-induced contractions likely reflects neuronal abnormalities due to autonomic neuropathy. However, structural changes and remodeling of the gastrointestinal tract are also evident and may add to the neuronal changes. This may contribute to the pathophysiology of diabetic gut dysfunction and impact on future management of diabetic patients with gastrointestinal symptoms.Jens BrΦndum FrΦkjΦr SΦren Due Andersen Niels EjskjΦr Peter Funch-Jensen AsbjΦrn Mohr Drewes Hans Gregersen 2007World Journal of Gastroenterology2007,13,36:8
2Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection显示文摘Nezam Afdhal Stefan Zeuzem Paul Kwo Mario Chojkier Norman Gitlin Massimo Puoti Manuel Romero-Gomez Jean-Pierre Zarski Kosh Agarwal Peter Buggisch Graham R. Foster Norbert Br?u Maria Buti Ira M. Jacobson G. Mani Subramanian Xiao Ding Hongmei Mo Jenny C. Ya 2014The New England Journal of Medicine2014,,:6
3Antifungal effects of yeast derived rhu GM-CSF in patients receiving high dose chemotherapy given with or without autologous stem cell transplantation:A retrospective analysis显示文摘Peters BG Adkins DR Harrison BR 1996Bone Marrow Transplant1996,18,1:1
4Network Support and the Success of Newly Founded Business显示文摘Josef Brüderl Peter Preisend?rfer 0,,:1
5Innate Immunity Conferred by Toll-like Receptors 2 and 4 and Myeloid Differentiation Factor 88 Expression Is Pivotal to Monosodium Urate Monohydrate Crystal- Induced Inflammation显示文摘Liu BR Peter S Anya S 2005Arthritis Rheum2005,52,9:1
6Supra-ductile and high-strength manganese TRIP/TWIP steels for high energy absorption purposes显示文摘Georg Frommeyer Udo Brüx Peter Neumann 2003ISIJ International2003,43,3:1
7Left dorsolateral prefrontal transcranial magnetic stimulation (TMS) : sleep factor changes daring treatment in patients with pharmaeorosistant major depressive disorder 显示文摘Peter BR Krystal A Karen LH 2013Psychiatry Research2013,205,:1
8Structural genitourinary defects detected in utero 显示文摘Mandell J Blyth BR Peters CA 1991Radiology1991,178,1:1
9Ambient Air Pollution and Lipoprotein-Associated Phospholipase A^sub 2^ in Survivors of Myocardial Infarction显示文摘Brüske Irene Hampel Regina Baumg?rtner Zita Rückerl Regina Greven Sonja Koenig Wolfgang Peters Annette Schneider Alexandra 2011Environmental Health Perspectives2011,,7:1
10Supra-ductile and high-strength manganese-TRIP/TWIP steels for high energy absorption purposes显示文摘Georg Frommeyer Udo Brüx Peter Neumann 2003ISIJ International2003,43,3:1
11The pattern of the mononuclear infiltrate as a prognostic parameter in flat superficial spreading melanomas显示文摘Eva-Bettina Br?cker Gerhard Kolde Detlef Steinhausen Almut Peters Egon Macher 1984Journal of Cancer Research and Clinical Oncology1984,,1:1
12Building successful strategic alliances显示文摘Peter Lorange Johan Roos and Peggy Simcic Br?nn 1992Long Range Planning1992,25,6:1
13Simultaneous atelectasis in human bocavirus infected monozygotic twins:was it plastic bronchitis显示文摘Christoph M Rüegger Walter Br Peter Iseli 2013BMC Pediatr2013,13,:1
14Chapter 20: Atopic demmtitis显示文摘Sabin BR Peters N Peters AT 2012Allergy Asthma Proc2012,33,1:1
15Treatment-related frequency of venous thrombosis in lower esophageal, gastro-esophageal and gastric cancer – a clinical prospective study of outcome and prognostic factors显示文摘Anders Christian Larsen Jens Br?ndum Fr?kj?r Rune Vincents Fisker Victor Iyer Peter Br?ndum Mortensen Mette Karen Yilmaz Bjarne M?ller S?ren Risom Kristensen Ole Thorlacius-Ussing 2015Thrombosis Research2015,,:1
16Structural genitourinary defects detectcd in Wtero显示文摘Mandell J Blyth BR peters CA 1991Radiology1991,178,:1
17Chapter 20: Atopic der- matitis显示文摘SABIN BR PETERS N PETERS AT 2012Allergy Asthma Proc2012,33,1:1
18A Prospective Study of the Incidence of Falls in Patients With Advanced Cancer显示文摘Carol Stone Peter G. Lawlor Bríd Nolan Rose Anne Kenny 2011Journal of Pain and Symptom Management2011,,4:1
19Importance of age and postimplantation expenenee on speech perception measnres inchildren with sequential bilateral cochlear implants显示文摘Peters BR Litovsky R Parkinson A 2007Otol Neurotol2007,28,5:1
20Acute confusion and mutism as a presentation of thalamic strokes secondary to deep cerebral venous thrombosis显示文摘Sanjeev VK David HE Peter BR 1998J Child Neurol1998,13,6:1
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