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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 3 | Lipocalin-2 Is a Disease Activity Marker in Inflammatory Bowel Disease Regulated by IL-17A, IL-22, and TNF-α and Modulated by IL23R Genotype Status显示文摘 | Johannes Stallhofer Matthias Friedrich Astrid Konrad-Zerna Martin Wetzke Peter Lohse Jürgen Glas Cornelia Tillack-Schreiber Fabian Schnitzler Florian Beigel Stephan Brand | 2015 | Inflammatory Bowel Diseases2015，，10： | 2 |
| 4 | Inter-reader variability in chest radiography and HRCT for the early detection of asbestos- related lung and pleural abnormalities in a cohort of 636 asbestos-exposed subjects显示文摘 | Elke Ochsmann Tanja Carl Peter Brand | 2010 | Int Arch Occup Environ Health2010，83，1： | 1 |
| 5 | Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn’s disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis显示文摘 | Julia Seiderer Fabian Schnitzler Stephan Brand Tanja Staudinger Simone Pfennig Karin Herrmann Katrin Hofbauer Julia Dambacher Cornelia Tillack Michael Sackmann Burkhard G?ke Peter Lohse Thomas Ochsenkühn | 2006 | Scandinavian Journal of Gastroenterology2006，，12： | 1 |
| 6 | Urinary excretion of low- molecular-weight proteins as prognostic markers in IgA nephropathy 显示文摘 | Peters HP van den Brand JA Wetzels JF | 2009 | Neth J Med2009，67，2： | 1 |
| 7 | Urinary excre- tion of low-molecular-weight proteins as prognostic mark- ers in IgA nephropathy显示文摘 | Peters HP van den Brand JA Wetzels JF | 2009 | Neth J Med2009，67，2： | 1 |
| 8 | Design and num- berical implementation of a 3-D non-linear viscoelastic consti- tutive model for brain tissue during impact 显示文摘 | Brands DW Peters GW Bovendeerd PH | 2004 | J Biomech2004，37，1： | 1 |
| 9 | Characterization of a Novel Human Cell-Cycle-Regulated Homologue of Drosophila dlg1显示文摘 | Sahar Bassal Nobuo Nomura Deon Venter Karl Brand Michael J. McKay Peter J. van der Spek | 2001 | Genomics2001，，1： | 1 |
| 10 | Alcohol and Smoking as Risk Factors in an Epidemiology Study of Patients With Chronic Pancreatitis显示文摘 | Gregory A. Coté Dhiraj Yadav Adam Slivka Robert H. Hawes Michelle A. Anderson Frank R. Burton Randall E. Brand Peter A. Banks Michele D. Lewis James A. Disario Timothy B. Gardner Andres Gelrud Stephen T. Amann John Baillie Mary E. Money Michael O’Connell | 2011 | Clinical Gastroenterology and Hepatology2011，，3： | 1 |
| 11 | High urinary excretion of kidney injury rnoleeule-1 is an independent predictor of end-stage renal disease in patients with IgA nephropathy 显示文摘 | Peters HP Waanders F Meijer E van den Brand J Steenbergen EJ van Goor H | 2011 | Nephrol Dial Transplant2011，26，11： | 1 |
| 12 | Alcohol and Smoking as Risk Factors in an Epidemiology Study of Patients With Chronic Pancreatitis显示文摘 | Gregory A. Coté Dhiraj Yadav Adam Slivka Robert H. Hawes Michelle A. Anderson Frank R. Burton Randall E. Brand Peter A. Banks Michele D. Lewis James A. Disario Timothy B. Gardner Andres Gelrud Stephen T. Amann John Baillie Mary E. Money Michael O’Connell | 2011 | Clinical Gastroenterology and Hepatology2011，，3： | 1 |
| 13 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 1 |
| 14 | The making of merlot显示文摘 | Brand Jim Weinberg Peter Radbumd Kate | 2002 | Wine industry journal2002，17，2： | 1 |
| 15 | Alcohol and Smoking as Risk Factors in an Epidemiology Study of Patients With Chronic Pancreatitis显示文摘 | Gregory A. Coté Dhiraj Yadav Adam Slivka Robert H. Hawes Michelle A. Anderson Frank R. Burton Randall E. Brand Peter A. Banks Michele D. Lewis James A. Disario Timothy B. Gardner Andres Gelrud Stephen T. Amann John Baillie Mary E. Money Michael O’Connell | 2011 | Clinical Gastroenterology and Hepatology2011，，3： | 1 |
| 16 | Practice guideline in acute pancreatits显示文摘 | PETER A BRANDS | 1997 | The American Journal of Gastroenterology1997，92，3： | 1 |
| 17 | Urinary excretion of low-molecular-weight proteins as prognostic nlarkers in IgA Nephwpathy显示文摘 | Peters HP van den Brand JA Wetzels JF | 2009 | Neth J Med2009，67，2： | 1 |
| 18 | The making ofmerlot显示文摘 | BRAND JIM WEINBERG PETER RADBUMD KATE | 2002 | Wine Industry Journal2002，17，2： | 1 |
| 19 | Advanced characterization of glass frit bonded micro-chevron-test samples based on scanning acoustic microscopy显示文摘 | Falk Naumann Sebastian Brand Michael Bernasch Sebastian Tismer Peter Czurratis Dirk Wünsch Matthias Petzold | 2013 | Microsystem Technologies2013，，5： | 1 |
| 20 | Intra-individual variability of serum hepcidin-25 in haemodialysis pa-tients using mass spectrometry and ELISA显示文摘 | Peters HP Rumjon A Bansal SS Laarakkers CM den Brand JA Sarafidis P Musto R Malyszko J Swin kels DW Wetzels JF Macdougall IC | 2012 | Nephrol Dial Transplant2012，27，： | 1 |
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