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| 1 | Laparoscopic Colectomy for Cancer Is Not Inferior to Open Surgery Based on 5-Year Data From the COST Study Group Trial显示文摘 | James Fleshman Daniel J. Sargent Erin Green Mehran Anvari Steven J. Stryker Robert W. Beart Michael Hellinger Richard Flanagan Walter Peters Heidi Nelson | 2007 | Annals of Surgery2007，，4： | 7 |
| 2 | Recommendations to quantify villous atrophy in video capsule endoscopy images of celiac disease patients显示文摘AIM To quantify the presence of villous atrophy in endoscopic images for improved automation.METHODS There are two main categories of quantitative descriptors helpful to detect villous atrophy:(1) Statistical and(2) Syntactic. Statistical descriptors measure the small intestinal substrate in endoscope-acquired images based on mathematical methods. Texture is the most commonly used statistical descriptor to quantify villous atrophy. Syntactic descriptors comprise a syntax, or set of rules, for analyzing and parsing the substrate into a set of objects with boundaries. The syntax is designed to identify and distinguish three-dimensional structures based on their shape.RESULTS The variance texture statistical descriptor is useful to describe the average variability in image gray level representing villous atrophy, but does not determine the range in variability and the spatial relationships between regions. Improved textural descriptors will incorporate these factors, so that areas with variability gradients and regions that are orientation dependent can be distinguished. The protrusion syntactic descriptor is useful to detect three-dimensional architectural components, but is limited to identifying objects of a certain shape. Improvement in this descriptor will require incorporating flexibility to the prototypical template, so that protrusions of any shape can be detected, measured, and distinguished.CONCLUSION Improved quantitative descriptors of villous atrophy are being developed, which will be useful in detecting subtle, varying patterns of villous atrophy in the small intestinal mucosa of suspected and known celiac disease patients. | Edward J Ciaccio Govind Bhagat Suzanne K Lewis Peter H Green | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，18： | 3 |
| 3 | Implementation of a polling protocol for predicting celiac disease in videocapsule analysis显示文摘AIM: To investigate the presence of small intestinal villous atrophy in celiac disease patients from quantitative analysis of videocapsule image sequences.METHODS: Nine celiac patient data with biopsy-proven villous atrophy and seven control patient data lacking villous atrophy were used for analysis. Celiacs had biopsy-proven disease with scores of Marsh Ⅱ-Ⅲ C except in the case of one hemophiliac patient. At four small intestinal levels (duodenal bulb, distal duodenum, jejunum, and ileum), video clips of length 200 frames (100 s) were analyzed. Twenty-four measurements were used for image characterization. These measurements were determined by quantitatively processing the videocapsule images via techniques for texture analysis, motility estimation, volumetric reconstruction using shape-from-shading principles, and image transformation. Each automated measurement method, or automaton, was polled as to whether or not villous atrophy was present in the small intestine, indicating celiac disease. Each automaton's vote was determined based upon an optimized parameter threshold level, with the threshold levels being determined from prior data. A prediction of villous atrophy was made if it received the majority of votes (≥ 13), while no prediction was made for tie votes (12-12). Thus each set of images was classified as being from either a celiac disease patient or from a control patient. RESULTS: Separated by intestinal level, the overall sensitivity of automata polling for predicting villous atrophy and hence celiac disease was 83.9%, while the specificity was 92.9%, and the overall accuracy of automata-based polling was 88.1%. The method of image transformation yielded the highest sensitivity at 93.8%, while the method of texture analysis using subbands had the highest specificity at 76.0%. Similar results of prediction were observed at all four small intestinal locations, but there were more tie votes at location 4 (ileum). Incorrect prediction which reduced sensitivity occurred for two celiac patients with Marsh type Ⅱ pattern, which is characterized by crypt hyperplasia, but normal villous architecture. Pooled from all levels, there was a mean of 14.31 ± 3.28 automaton votes for celiac vs 9.67 ± 3.31 automaton votes for control when celiac patient data was analyzed (P<0.001). Pooled from all levels, there was a mean of 9.71 ± 2.8128 automaton votes for celiac vs 14.32 ± 2.7931 automaton votes for control when control patient data was analyzed (P<0.001). CONCLUSION: Automata-based polling may be useful to indicate presence of mucosal atrophy, indicative of celiac disease, across the entire small bowel, though this must be confirmed in a larger patient set. Since the method is quantitative and automated, it can potentially eliminate observer bias and enable the detectionof subtle abnormality in patients lacking a clear diagnosis. Our paradigm was found to be more efficacious at proximal small intestinal locations, which may suggest a greater presence and severity of villous atrophy at proximal as compared with distal locations. | Edward J Ciaccio Christina A Tennyson Govind Bhagat Suzanne K Lewis Peter H Green | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 3 |
| 4 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 5 | Impact of a simulation-based induction programme in gastroscopy on trainee outcomes and learning curves显示文摘BACKGROUND Pre-clinical simulation-based training(SBT)in endoscopy has been shown to augment trainee performance in the short-term,but longer-term data are lacking.AIM To assess the impact of a two-day gastroscopy induction course combining theory and SBT(Structured PRogramme of INduction and Training–SPRINT)on trainee outcomes over a 16-mo period.METHODS This prospective case-control study compared outcomes between novice SPRINT attendees and controls matched from a United Kingdom training database.Study outcomes comprised:(1)Unassisted D2 intubation rates;(2)Procedural discomfort scores;(3)Sedation practice;(4)Time to 200 procedures;and(5)Time to certification.RESULTS Total 15 cases and 24 controls were included,with mean procedure counts of 10 and 3(P=0.739)pre-SPRINT.Post-SPRINT,no significant differences between the groups were detected in long-term D2 intubation rates(P=0.332)or discomfort scores(P=0.090).However,the cases had a significantly higher rate of unsedated procedures than controls post-SPRINT(58%vs 44%,P=0.018),which was maintained over the subsequent 200 procedures.Cases tended to perform procedures at a greater frequency than controls in the post-SPRINT period(median:16.2 vs 13.8 per mo,P=0.051),resulting in a significantly greater proportion of cases achieving gastroscopy certification by the end of follow up(75% vs 36%,P=0.017).CONCLUSION In this pilot study,attendees of the SPRINT cohort tended to perform more procedures and achieved gastroscopy certification earlier than controls.These data support the role for wider evaluation of pre-clinical induction involving SBT. | Keith Siau James Hodson Peter Neville Jeff Turner Amanda Beale Susi Green Aravinth Murugananthan Paul Dunckley Neil D Hawkes | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，3： | 2 |
| 6 | Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders显示文摘 | E Joanna Baxter Linda M Scott Peter J Campbell Clare East Nasios Fourouclas Soheila Swanton George S Vassiliou Anthony J Bench Elaine M Boyd Natasha Curtin Mike A Scott Wendy N Erber Anthony R Green | 2005 | The Lancet . 2005 (9464)2005，，： | 2 |
| 7 | Celiac disease in Middle Eastern and North African countries:A new burden?显示文摘Celiac disease(CD) is now recognized as a common disorder among Middle Eastern(ME) and North African(NA) populations.The aim of this review is to assess the available data regarding CD in the ME and NA and to compare this information with that of Western countries.A literature review was performed using the electronic databases PubMed and Medline(1950-2008) as search engines,and 'celiac disease' was used as a Mesh term.The search was limited to ME and NA countries.The prevalence of CD in ME and NA countries among low risk populations is similar to that of Western countries,but is higher in high risk populations such as those with type 1 diabetes.It is underestimated because of lack of clinical suspicion and lack of patient awareness.Clinical presentations in term of gastrointestinal,hematologic,skeletal,and liver manifestations are similar between both populations except for a high prevalence of short stature in some ME and NA countries.Few studies have addressed atypical or silent CD.As in the West,diagnosis is initially made by serological tests and is confirmed by small intestinal biopsies.Gluten-free diet is the main mode of treatment with a higher apparent adherence rate than in the West.Most disease complications result from malabsorption.The disease is strongly associated with HLA DQ2 and to a lesser extent with HLA DQ8 alleles.In conclusion,CD prevalence is underestimated,with little data available about its malignant complications.Disease parameters in the ME and NA are otherwise similar to those in Western countries. | Kassem Barada Abbas Bitar Mohamad Abdul-Razak Mokadem Jana Ghazi Hashash Peter Green | 2010 | World Journal of Gastroenterology2010，16，12： | 2 |
| 8 | Celiac Disease Is Diagnosed Less Frequently in Young Adult Males显示文摘 | Rohit Dixit Benjamin Lebwohl Jonas F. Ludvigsson Suzanne K. Lewis Norelle Rizkalla-Reilly Peter H. R. Green | 2014 | Digestive Diseases and Sciences2014，，7： | 2 |
| 9 | Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet显示文摘 | Sean W.P. Koppe Atul Sahai Padmini Malladi Peter F. Whitington Richard M. Green | 2004 | Journal of Hepatology2004，，4： | 1 |
| 10 | Accurate Current Control to Drive High Power LED 显示文摘 | Odile Ronat Peter Green Scott Ragona | 2006 | IEEE Publication2006，，6： | 1 |
| 11 | Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts显示文摘 | Peters NS Green CR Poole-Wilson PA | 1993 | Circulation1993，88，3： | 1 |
| 12 | Quantitative Estimates of Motility from Videocapsule Endoscopy Are Useful to Discern Celiac Patients from Controls显示文摘 | Edward J. Ciaccio Christina A. Tennyson Govind Bhagat Suzanne K. Lewis Peter H. Green | 2012 | Digestive Diseases and Sciences2012，，11： | 1 |
| 13 | Use of shape-from-shading to estimate three-dimensional architecture in the small intestinal lumen of celiac and control patients显示文摘 | Edward J. Ciaccio Christina A. Tennyson Govind Bhagat Suzanne K. Lewis Peter H.R. Green | 2013 | Computer Methods and Programs in Biomedicine2013，，3： | 1 |
| 14 | Diagnostic criteria for selenium toxicosis in aquatic birds: histologic lesions显示文摘 | GREEN D E PETER H A | 1997 | Journal of Wildlife1997，33，3： | 1 |
| 15 | Voltage Sag Detection Technique for a Dynamic Voltage Restorer显示文摘 | Mike Barnes Peter Green | 2004 | IEEE Transactions on Industry Applications Jan/Feb2004，40，1： | 1 |
| 16 | Seronegative Celiac Disease: Increased Prevalence with Lesser Degrees of Villous Atrophy显示文摘 | Julian A. Abrams Beverly Diamond Heidrun Rotterdam Peter H. R. Green | 2004 | Digestive Diseases and Sciences2004，，4： | 1 |
| 17 | Reduced content of connexin 43 gap junctions in ventricular myoeardium from hypertrophied and ischemic human hearts显示文摘 | Peters NS Green CR Poole-Wilson PA | 1993 | Circulation1993，88，： | 1 |
| 18 | Cardiac arrhythmogene- sis and the gap junction 显示文摘 | Peters Ns Green Cr Pool Ewilson PA | 1995 | J Mol Cell Cordial1995，27，： | 1 |
| 19 | The potential role of ER beta isoforms in the clinical management of breast cancer显示文摘 | Green CA Peter MB Speirs V | 2008 | Histopathology2008，53，： | 1 |
| 20 | Prevalence of Migraine in Patients With Celiac Disease and Inflammatory Bowel Disease显示文摘 | Alexandra K. Dimitrova Ryan C. Ungaro Benjamin Lebwohl Suzanne K. Lewis Christina A. Tennyson Mark W. Green Mark W. Babyatsky Peter H. Green | 2012 | Headache: The Journal of Head and Face Pain2012，，2： | 1 |
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