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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Increased particulate air pollution and the triggering of myocardial infarction显示文摘 | Peters A Dockery DW Muller JE | 2001 | Circulation2001，103，： | 1 |
| 3 | Increased particulate air pollution and the triggering of myocardial infarction显示文摘 | Peters A Dockery DW Muller JE | 2001 | Circulation2001，103，： | 1 |
| 4 | Engineering and characterization of functional human microvessels in im- munodeficient mice显示文摘 | Nor JE Peters Me Christensen JB | 2001 | Lab Invest2001，81，： | 1 |
| 5 | Imprinted noncoding RNAs显示文摘 | Peters J Robson JE | 2008 | Mamm Genome2008，19，78： | 1 |
| 6 | Psychometric analysis of the University of Wisconsin Interstitial Cystitis Scale:implications for use in randomized clinical trials显示文摘 | Goin JE Olaleye D Peters KM | 1998 | J Urol1998，15，9： | 1 |
| 7 | Airway remodeling and persistent airway obstruction in asthma显示文摘 | Fish JE Peters SP | 1999 | J Allergy Clin Immunol1999，104，31： | 1 |
| 8 | Investigation and control of aspergillosis and other filamentous fungal infections in solid organ transplant recipients 显示文摘 | Peters J Calhoon JH | 2000 | Transpl Infect Dis2000，2，1： | 1 |
| 9 | Increased particulate air pollution and the triggering of myocardial infarction 显示文摘 | PETERS A DOCKERY DW MULLER JE | 2001 | Circulation2001，103，23： | 1 |
| 10 | Investigation and control of aspergillusis and other filamentous fungal infections solid organ transplant recipients显示文摘 | Pattereson JE Peters J Cahoon J H | 2000 | Transplant Infect Dis2000，2，22： | 1 |
| 11 | Engineering and characterization of functional human microvessels in immunodeficient mice显示文摘 | NOR JE Peters MC Chrlstensen JB | 2001 | Lab Invest2001，81，10： | 1 |
| 12 | Increased particulate air pollution and the triggering of myocardial infraction 显示文摘 | Peters A Dockery DW Muller JE | 2001 | Circulation2001，103，： | 1 |
| 13 | Airway remodeling and persistent airway obstruction in asthma显示文摘 | Fish JE Peters SP | 1999 | J Allergy clin Immunol1999，104，31： | 1 |
| 14 | Investigaton and control of aspergillosis and other filamentous fungal infections in solid organ transplant recipients显示文摘 | Patterson JE Peters J Calhoon JH | 2000 | Transplant Infect Dis2000，2，： | 1 |
| 15 | Airway remodelling and persistent airway obstruction in asthma显示文摘 | Fish JE Peters SP | 1999 | J Allergy Clic Immunol1999，9，： | 1 |
| 16 | Developmental patterns of laryngeal and respiratory function for speech production显示文摘 | Netsei1 R Lotz WK Peters JE | 1994 | J Voice1994，8，2： | 1 |
| 17 | Proteasome inhibition: a new anti - inflammatory strategy 显示文摘 | Peter JE Thomas MZ Wolf - Henning B | 2003 | J Mol Med2003，81，4： | 1 |
| 18 | Tuberculosis and anti-TNF treatment: experience of a central London hospital显示文摘 | Mankia S Peters JE Kang S | 2011 | Clin Rheumatol2011，30，3： | 1 |
| 19 | Increased particulate air pollution and the triggering of myocardial infarction显示文摘 | Peters A Dockery DW Muller JE | 2001 | Circulation2001，103，23： | 1 |
| 20 | Up-regulation of Bcl-2 in miccrovascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth 显示文摘 | Nor JE Christensen J Liu J Peters M Mooney DJ Stricter RM | 2001 | Cancer Res2001，61，5： | 1 |
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