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| 1 | Heat shock protein 47 promotes tumor survival and therapy resistance by modulating AKT signaling via PHLPP1 in colorectal cancer显示文摘Objective:Heat shock protein 47(HSP47)is a collagen-specific molecular chaperone that facilitates collagen maturation.Its role in cancer remains largely unknown.In this study,we investigated the roles o f HSP47 in colorectal cancer(CRC)and therapy resistance.Methods:Expression o f HSP47 in CRC tissues was examined(1)in paired human CRC/adjacent normal tissues,using real time quantitative reverse transcription polymerase chain reaction(qRT-PCR),The Cancer Genome Atlas(TCGA)database,and 22 independent m icroarray databases(curated CRC).In vitro studies on several CRC cell lines(H C T 116,RKO and C C L228)with modulated HSP47 expression were conducted to assess cell viability and apoptosis(TU N EL assay and caspase-3/-7)during exposure to chemotherapy.AKT signaling and co-imm unoprecipitation studies were performed to examine HSP47 and PHLPP1 interaction.In vivo studies using tumor xenografts were conducted to assess the effects of HSP47 modulation on tum or growth and therapy response.Results:HSP47 was upregulated in CRC and was associated with poor prognosis in individuals with CRC.In vitro,HSP47 overexpression supported the survival of CRC cells,whereas its knockdown sensitized cells to 5-fluorouracil(5-FU).HSP47 promoted survival by inhibiting apoptosis,enhancing AKT phosphorylation,and decreasing expression of the AKT-specific phosphatase PHLPP1 when cells were exposed to chemotherapy.These effects were partly results of the interaction between HSP47 and PHLPP1,which decreased PHLPP1 stability and led to more persistent AKT activity.In vivoy HSP47 supported tumor growth despite 5-FU treatment.Conclusions:HSP47 supports the growth of CRC tumors and suppresses the efficacy of chemotherapy via modulation of AKT signaling. | Yijye Chern Peter Zhang Hyelim Ju Isabella T.Tai | 2020 | Cancer Biology & Medicine2020，17，2： | 3 |
| 2 | Enhancement of the performance of gas hydrate kinetic inhibitors with polyethylene oxide显示文摘 | Ju Dong Lee Peter Englezos | 2005 | Chemical Engineering Science2005，，19： | 1 |
| 3 | Synthesis of serotonin by a second tryptophan hydroxylase isoform 显示文摘 | Walther DJ Peter JU BashammakhS | 2003 | Science2003，299，： | 1 |
| 4 | Synthesis of sero- tonin by a second tryptophan hydroxylase isoformp显示文摘 | Walther DJ Peter JU Bashammakh S | 2003 | Science2003，299，5603： | 1 |
| 5 | Synthesis of serotonin by a second tryptophan hydroxylase isoform 显示文摘 | Wahher DJ Peter JU Bashammakh S | 2003 | Science2003，299，： | 1 |
| 6 | Enhancement of the performance of gas hydrate kinetic inhibitors with polyethylene oxide 显示文摘 | JU DONG LEE PETER ENGLEZOS | 2005 | Chemical Engineering Science2005，60，： | 1 |
| 7 | Cationic starches as gas hydrate kinetic inhibitors显示文摘 | JU DONG LEE HUI JIE WU PETER ENGLEZOS | 2007 | Chemical Engineering Science2007，62，： | 1 |
| 8 | Radiation-and Convection-Driven Transient Heat Transfer During Sublimation Growth of Silicon Carbide Single Crystals显示文摘 | Olaf Klein Peter Philip Jurgen Sprekels | 2001 | Journal of Crystal Growth2001，222，： | 1 |
| 9 | Nitrogen dynamics and budgets in a winter wheat–maize cropping system in the North China Plain显示文摘 | Xuejun Liu Xiaotang Ju Fusuo Zhang Jiarong Pan Peter Christie | 2003 | Field Crops Research2003，，2： | 1 |
| 10 | Synthesis of serotonin by a second tryptophan hydroxylase isoform显示文摘 | Walther DJ Peter JU Bashammakh S | 2003 | Science2003，299，： | 1 |
| 11 | Synthesis of seroto- nin by a second tryptophan hydroxylase isoform显示文摘 | Bashammakh S Walther DJ Peter JU | 2003 | Science2003，299，3： | 1 |
| 12 | Creatine feeding increases Glut 4 expression in rat skeletal muscle显示文摘 | Jeong - Sun Ju Jill L Smith Peter J Oppelt | 2005 | Am Physiol Endocrinol Metab2005，，288： | 1 |
| 13 | Randomized controlled trial of recombinant alpha-2a-interferon for chronic hepatitis C显示文摘 | David D. Douglas MD Dr. Jorge Rakela MD Hsiang Ju Lin DSc F. Blaine Hollinger MD Howard F. Taswell MD Albert J. Czaja MD John B. Gross MD Monte L. Anderson MD Kevin Parent MD C. Richard Fleming MD John R. Cangemi MD Peter C. O’Brien PhD Pauline E. Powis R | 1993 | Digestive Diseases and Sciences1993，，4： | 1 |
| 14 | Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha- granule release显示文摘 | Walther D J Peter JU Winter S | 2003 | Ce112003，115，7： | 1 |
| 15 | Synthesis of serotonin by a second tryptophan hydroxylase isoform显示文摘 | Walther DJ Peter JU Bashamrnakh S | 2003 | Science2003，299，5603： | 1 |
| 16 | Synthesis of serotonin by a second tryptophan hydroxylase isoform显示文摘 | Wahher DJ Peter JU Bashammakh S | 2003 | Science2003，299，5603： | 1 |
| 17 | The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain显示文摘 | Hyeon Ju Kim Peter Leeds De‐Maw Chuang | 2009 | Journal of Neurochemistry2009，，4： | 1 |
| 18 | Quantication of the major brown shrimp allergen Pen a 1 (tropomyosin)by a monoclonal antibody-based sandwich ELISA显示文摘 | Byeoung Ju Jeoung MD Gerald Reese phD Peter Hauck BS | 1997 | Journal of Allergy clinicaland immunology1997，100，2： | 1 |
| 19 | Reducing environmental risk by improving N management in intensive Chinese agricultural systems 显示文摘 | Ju X T Xing G X Chen X P Zhang S 1 Zhang L J Liu X J Cui Z L Yin B Peter C Zhu Z L Zhang F S | 2009 | Proceedings of the National Academy of Sciences of the USA (PNAS)2009，106，9： | 1 |
| 20 | Atomistic modeling of mechanical behavior显示文摘 | JU Li ALFONSO H W N PETER G | 2003 | Acta Materialia2003，51，： | 1 |
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