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| 1 | Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review显示文摘AIM:To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten(PTEN)hamartoma tumor syndrome(PHTS)and to perform a systematic literature review regarding the same.METHODS:This study was approved by the appropriate institutional review board prior to initiation.A clinical genetics database was searched for patients with PHTS or a component syndrome that received gastrointestinal endoscopy or pathology interpretation at our center.These patient’s records were retrospectively reviewed for clinical characteristics(including family history and genetic testing),endoscopy results and pathology findings.We also performed a systematic review of the literature for case series of PHTS or component syndromes that reported gastrointestinal manifestations and investigations published after consensus diagnostic criteria were established in 1996.These results were compiled and reported.RESULTS:Eight patients from our institution met initial inclusion criteria.Of these,5 patients underwent4.2 colonoscopies at mean age 45.8±10.8 years.All were found to have colon polyps during their clinical course and polyp histology included adenoma,hyperplastic,ganglioneuroma and juvenile.No malignant lesions were identified.Two had multiple histologic types.One patient underwent colectomy due to innumerable polyps and concern for future malignant potential.Systematic literature review of PHTS patients undergoing endoscopy revealed 107 patients receiving colonoscopy at mean age 37.4 years.Colon polyps were noted in92.5%and multiple colon polyp histologies were reported in 53.6%.Common polyp histologies included hyperplastic(43.6%),adenoma(40.4%),hamartoma(38.3%),ganglioneuroma(33%)and inflammatory(24.5%)polyps.Twelve(11.2%)patients had colorectal cancer at mean age 46.7 years(range 35-62).Clinical outcomes secondary to colon polyposis and malignancy were not commonly reported.CONCLUSION:PHTS has a high prevalence of colon polyposis with multiple histologic types.It should be considered a mixed polyposis syndrome.Systematic review found an increased prevalence of colorectal cancer and we recommend initiating colonoscopy for colorectal cancer surveillance at age 35 years. | Peter P Stanich Robert Pilarski Jonathan Rock Wendy L Frankel Samer El-Dika Marty M Meyer | 2014 | World Journal of Gastroenterology2014，20，7： | 5 |
| 2 | Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia显示文摘Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems feasible.However,sensitive diagnostic tools will be required to determine whether elimination has been achieved.We compared several standard and novel diagnostic tools in S.mekongi-endemic areas.Methods:The prevalence and infection intensity of S.mekongi were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow tests.Two highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were utilized.Results:Stool microscopy revealed an overall prevalence of S.mekongi of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,Trichuris trichiura,Ascaris lumbricoides and Taenia spp.were 50.4%,28.1%,3.5%,0.3%and 1.9%,respectively.In the urine samples,the tests for CCA and CAA detected S.mekongi infections in 21.0%and 38.7%of the study participants,respectively.In the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.There was a difference between the two study locations with a higher prevalence reached in the samples from Lao PDR.Conclusions:The CCA,CAA and ELISA results showed substantially higher prevalence estimates for S.mekongi compared to Kato-Katz thick smears.Active schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated previously.Hence,sustained control efforts are still needed to break transmission of S.mekongi.The pivotal role of highly sensitive diagnostic assays in areas targeting elimination cannot be overemphasised. | Youthanavanh Vonghachack Somphou Sayasone Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje THoekstra Paul L.A.M.Corstjens Beatrice Nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 3 | Design of concrete slabs for transverse shear显示文摘 | PETER MARTI | 1990 | ACI Structural Journal1990，87，2： | 1 |
| 4 | Load Tests on Post- tensioned Masonry Walls显示文摘 | Nebojsa Mojsilovic Peter Marti | 2000 | TMS Journal2000，7，： | 1 |
| 5 | Design of concrete slabs for transverse shear显示文摘 | PETER MARTI | 1990 | ACI Structural Journal1990，87，2： | 1 |
| 6 | Assessing stool quantities generated by three specific Kato-Katz thick smear templates employed in different settings显示文摘Background:The Kato-Katz technique is recommended for the diagnosis of helminth infections in epidemiological surveys,drug efficacy studies and monitoring of control interventions.We assessed the comparability of the average amount of faeces generated by three Kato-Katz templates included in test kits from two different providers.Methods:Nine hundred Kato-Katz thick smear preparations were done;300 per kit.Empty slides,slides plus Kato-Katz template filled with stool and slides plus stool after careful removal of the template were weighed to the nearest 0.1 mg.The average amount of stool that was generated on the slide was calculated for each template,stratified by standard categories of stool consistency(i.e.mushy,soft,sausage-shaped,hard and clumpy).Results:The average amount of stool generated on slides was 40.7 mg(95%confidence interval(CI):40.0–41.4 mg),40.3 mg(95%CI:39.7–40.9 mg)and 42.8 mg(95%CI:42.2–43.3 mg)for the standard Vestergaard Frandsen template,and two different templates from the Chinese Center for Disease Control and Prevention(China CDC),respectively.Mushy stool resulted in considerably lower average weights when the Vestergaard Frandsen(37.0 mg;95%CI:34.9–39.0 mg)or new China CDC templates(37.4 mg;95%CI:35.9–38.9 mg)were used,compared to the old China CDC template(42.2 mg;95%CI:40.7–43.7 mg)and compared to other stool consistency categories.Conclusion:The average amount of stool generated by three specific Kato-Katz templates was similar(40.3–42.8 mg).Since the multiplication factor is somewhat arbitrary and small changes only have little effect on infection intensity categories,it is suggested that the standard multiplication factor of 24 should be kept for the calculation of eggs per gram of faeces for all investigated templates. | Andrea Leuenberger Tatu Nassoro Khadija Said Lukas Fenner George Sikalengo Emilio Letang Antonio Montresor Xiao-Nong Zhou Peter Steinmann Hanspeter Marti Jürg Utzinger Stefanie Knopp | 2016 | Infectious Diseases of Poverty2016，5，1： | 1 |
| 7 | National trends in approach and outcomes with appendicitis in children显示文摘 | Alessandra C. Gasior Shawn D. St. Peter E. Marty Knott Matt Hall Daniel J. Ostlie Charles L. Snyder | 2012 | Journal of Pediatric Surgery2012，，12： | 1 |
| 8 | Follicle -forming cat thyroid cell lines synthesizing extracellular matrix and basal membrane components:a new toot for the study of thyroidal morphogenesis显示文摘 | TOGNELLA C MARTI U PETER H J | 1999 | J Endocrinol1999，163，： | 1 |
| 9 | Energy proportional datacenter networks显示文摘 | Dennis Abts Michael R. Marty Philip M. Wells Peter Klausler Hong Liu | 2010 | ACM SIGARCH Computer Architecture News2010，，3： | 1 |
| 10 | Design of concrete slabs for transverse shear显示文摘 | MARTI PETER | 1990 | ACI Structural Journal1990，87，2： | 1 |
| 11 | Robert Maillart' s Curved Concrete Arch Bridges显示文摘 | Massimo Laffranchi Peter Marti | 1997 | Journal of Structural Engineering1997，123，10： | 1 |
| 12 | Decreased phosphorylation of a low molecular weight protein by cGMP-dependent protein kinase in variant HL-60 cells resistant to nitric oxide- and cGMP-induced differentiation显示文摘 | Jurgen S. Scheele Renate B. Pilz Gregory Clark Nigel Gupta Debbie Loo Peter Martis Gerry R. Boss | 1998 | Molecular and Cellular Biochemistry (-)1998，，1： | 1 |
| 13 | The prevalence and diversity of intestinal parasitic infections in humans and domestic animals in a rural Cambodian village显示文摘 | Fabian Sch?r Tawin Inpankaew Rebecca J. Traub Virak Khieu Anders Dalsgaard Wissanuwat Chimnoi Chamnan Chhoun Daream Sok Hanspeter Marti Sinuon Muth Peter Odermatt | 2014 | Parasitology International2014，，4： | 1 |
| 14 | Design of Concrete Slabs for Transverse Sbear显示文摘 | PETER MARTI | 1990 | ACI Structural Journal1990，87，2： | 1 |
| 15 | Load Tests on Post-Tensioned Masonry Walls显示文摘 | Nebojsa Mojsilovic Peter Marti | 2000 | TMS Journal2000，20，1： | 1 |
| 16 | Design of concrete slabs for transverse shear显示文摘 | PETER MARTI | 1990 | ACI Structural Journal1990，87，2： | 1 |
| 17 | 泰尔砖屋 美国芝加哥市埃文斯顿显示文摘位于芝加哥郊区西北大学校园内的几个街区内,这个大小适宜的庭院式房屋几乎完全被砖包裹。就像大家知道的那样,芝加哥“普通”砖之所以被选中是因为他们看起来与典型的红砖不同——这是当地密歇根湖粘土的地质成分和烧制方式的结果。它的多样性和不规则性让“普通”砖顿失吸引力,便宜的价格和丰富的来源——一种平凡的建筑材料被用在远离街道的地方,比如说侧墙和后侧的墙,烟囱烟道和立面后面的结构支撑。 | Marty Peters(摄影) | 2023 | 世界建筑导报2023，38，4： | 0 |
| 18 | Strongyloides stercoralis prevalence and diagnostics in Vientiane, Lao People’s Democratic Republic显示文摘Background:Despite the high prevalence of strongyloidiasis in the Laotian population,Laotian hospitals still lack diagnostic capacity to appropriately diagnose Strongyloides stercoralis infections.This cross-sectional hospital-based study was conducted to assess the prevalence of Strongyloides stercoralis infection among hospitalized patients treated at Mahosot Hospital,the primary reference hospital of Lao People’s Democratic Republic(Lao PDR),and to validate feasible methods for diagnosing S.stercoralis infection at hospital’s laboratory.Methods:Between September and December 2018,stool samples of 104 inpatients were investigated for S.stercoralis infection by wet smear,Baermann technique,Koga Agar plate culture(KAPC),and real-time detection polymerase chain reaction(RTD-PCR)at the Infectious Diseases Ward of the Mahosot Hospital in Vientiane.The sensitivity,the specificity,the negative predictive value(NPV)of each diagnostic test,as well as their combination(s)was calculated using a composite reference standard(CRS).The correlation of the different test methods was assessed by chi-square or Fisher’s exact test.Cohen’s kappa coefficient was used to assess the diagnostic agreement of the different test methods.Results:The overall prevalence of S.stercoralis infections among the study population was 33.4%.The cumulative infection prevalence statistically significantly increased from the lowest age group of 40 years and below(22.4%),to the medium(40.0%)and to the oldest age group of 61 year and above(72.7%)(P=0.003).The cumulative infection prevalence of CRS was considerably higher in male(40.4%)compared to female patients(28.1%),but not statistically different(P=0.184).The diagnostic sensitivity of Baermann technique,KAPC,RTD-PCR,and the combination of Baermann technique and KAPC were 60.0,60.0,74.3,and 77.1%,respectively.Only 13 patients(37.1%)of the total 35 S.stercoralis patients diagnosed with any technique had a simultaneously positive diagnostic test with Baermann,KAPC and RTD-PCR.Conclusions:We identified Baermann technique and KAPC to be currently the most feasible and implementable standard methods for diagnosing S.stercoralis at a hospital setting such as Mahosot Hospital and provincial and district hospitals in Lao PDR and other low-and middle income countries in Southeast Asia.Trial registration:This study was approved by the National Ethics Committee for Health Research in Lao PDR(reference no.083/NECHR)and by the Ethics Committee Northwest and Central Switzerland(reference no.2018–00594). | Somaphone Chankongsin Rahel Wampfler Marie-Therese Ruf Peter Odermatt Hanspeter Marti Beatrice Nickel Valy Keoluangkhot Andreas Neumayr | 2020 | Infectious Diseases of Poverty2020，9，5： | 0 |
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