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| 1 | Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research显示文摘Purpose:To review the clinical and research value of optical coherence tomography angiography(OCTA)in the field of neurology.Methods:Current literature involving OCTA were reviewed through PubMed using the search terms“optical coherence tomography angiography”,with“multiple sclerosis”,“Alzheimer’s disease”,“optic neuropathy”,or other closely-related terms.Results:OCTA has been applied in research to advance our understanding of the pathobiology of neurological disorders.OCTA-derived blood flow and vessel density measures are altered in multiple sclerosis(MS),Alzheimer’s disease(AD),and various optic neuropathies(ON)in varying regions of the posterior segment vasculature of the eye.These emerging research findings support the occurrence of retinal vascular alterations across a host of neurological disorders and raise the possibility that vasculopathy can be clinically relevant since it contributes to the pathobiology of several neurological disorders.Conclusion:OCTA may be beneficial for neurological research.Additional investigations using OCTA in neurological disorders will help to further validate its clinical and research utilities in terms of characterizing the role of vasculopathy in neurological disorders. | Liang Wang Olwen Murphy Natalia Gonzalez Caldito Peter A.Calabresi Shiv Saidha | 2018 | Eye and Vision2018，5，1： | 6 |
| 2 | Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma:Results from the FINBAR study显示文摘AIM:To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.METHODS:This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients,227 oesophageal adenocarcinoma patients and 260 controls.All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.RESULTS:Gastro-oesophageal reflux was associated with Barrett's [OR 12.0(95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48(95% CI 2.25-5.41)].Oesophageal adenocarcinoma patients were more likely than controls to be ex-or current smokers [OR 1.72(95% CI 1.06-2.81)and OR 4.84(95% CI 2.72-8.61)respectively] and to have a high body mass index [OR 2.69(95% CI 1.62-4.46)].No significant associations were observed between these risk factors and Barrett's oesophagus.Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50(95% CI 0.30-0.86)].CONCLUSION:A high body mass index,a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma. | Lesley A Anderson RG Peter Watson Seamus J Murphy Brian T Johnston Harry Comber Jim Mc Guigan John V Reynolds Liam J Murray | 2007 | World Journal of Gastroenterology2007，13，10： | 5 |
| 3 | 膀胱癌多发或复发的克隆起源显示文摘目的 探讨人膀胱移行上皮癌多发性、复发性的细胞克隆来源。 方法 采用p53基因突变的PCR SSCP分析及DNA测序检测 6例患者 1 4个表浅、低分级原发加多发或复发的膀胱移行上皮癌标本及p2 1 WAF1 /CIP1 蛋白的表达。 结果 在 1 4个膀胱移行上皮癌标本中均有p53基因的点突变 ,同一例患者所有标本的点突变分别在同一位点上 ;1 4个膀胱移行上皮癌标本中仅有 5个有p2 1 WAF1 /CIP1 蛋白的表达。 结论 多发或复发膀胱移行上皮癌都可能来源于同一细胞 ,即单克隆起源。p2 1 WAF1 /CIP1 蛋白的表达既有 | 叶定伟 李慧 Peter Murphy 孙颖浩 钱松溪 郑家富 马永江 | 2000 | 中华泌尿外科杂志2000，21，5： | 4 |
| 4 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 5 | 一种基于联合源-滤波器模型优化的语音声门源模型估计方法显示文摘本文论述了一种基于联合源-滤波器分离的稳健声门源模型估计方法.此方法利用LF(Liljencrants-Fant)模型对声门波导数(glottal flow derivative)进行建模,而声道被描述为一个时变的ARX模型.由于联合估计问题是一个多变量非线性优化过程,本文采用了一个两阶段(two-pass)的实现策略来解决这一问题.第一阶段初始化声门源和声道模型,并为其后的联合优化过程提供稳健的初始参数.第二阶段的联合估计则最终决定模型估计的精度,由信任域下降优化算法实现.通过分别对合成和真实语音的实验,表明该方法是一种具有一定精度和较好的稳健性的声门源模型估计算法. | 付强 Peter Murphy 颜永红 | 2007 | 电子学报2007，35，5： | 3 |
| 6 | Tourism Destinations as Clusters: Analytical Experiences from the New World 显示文摘 | Julie Jackson Peter Murphy | 2002 | Tourism and Hospitality Research2002，4，1： | 1 |
| 7 | Tourism in British Columbia:Metropolitan and Camping Visitors显示文摘 | MURPHY PETER | 1979 | Annals of Toudsm Research1979，6，3： | 1 |
| 8 | Assessing tillage disturbance on assemblages of ground beetles (Coleoptera: Carabidae) by using a range of ecological indices显示文摘 | Svenja Belaoussoff Peter G. Kevan Stephen Murphy Clarence Swanton | 2003 | Biodiversity and Conservation2003，，5： | 1 |
| 9 | Open Versus Laparoscopic Pyloromyotomy for Pyloric Stenosis: A Prospective, Randomized Trial显示文摘 | Shawn D. St. Peter George W. Holcomb Casey M. Calkins J Patrick Murphy Walter S. Andrews Ronald J. Sharp Charles L. Snyder Daniel J. Ostlie | 2006 | Annals of Surgery2006，，3： | 1 |
| 10 | Attracting Japanese tourists into the rural hinterland:Implications for rural development and planning 显示文摘 | Ann Murphy Peter W Williams | 1999 | Tourism Management1999，，： | 1 |
| 11 | Sustained release of vascular endothelial growth factor from mineralized poly (lactide-co-glycolide) scaffolds for tissue engineerin显示文摘 | Murphy WL Peters MC Kohn DH | 2000 | Biomaterials2000，21，24： | 1 |
| 12 | Clusters in Regional Tourism an Australian Case 显示文摘 | Julie Jackson Peter Murphy | 2006 | Annals of Tourism Research2006，，4： | 1 |
| 13 | Regulatory Effects of iNOS on Acute Lung Inflammatory Responses in Mice显示文摘 | Cecilia L. Speyer Thomas A. Neff Roscoe L. Warner Ren-Feng Guo J. Vidya Sarma Niels C. Riedemann Megan E. Murphy Hedwig S. Murphy Peter A. Ward | 2003 | The American Journal of Pathology2003，，： | 1 |
| 14 | Asthma in Pregnancy显示文摘 | Vanessa E. Murphy Peter G. Gibson | 2011 | Clinics in Chest Medicine2011，，1： | 1 |
| 15 | Tourism and disaster planning显示文摘 | Peter E Murphy Robin Bayley | 1989 | Geographical Review1989，79，1： | 1 |
| 16 | Clusters in Regional Tourism an Australian Case显示文摘 | Julie Jackson Peter Murphy | 2006 | Annals of Tourism Research2006，，4： | 1 |
| 17 | Clusters in Regional Tot, rism: An Australian Case 显示文摘 | Julie Jackson Peter Murphy | 2006 | Annals of Tourism Research2006，33，4： | 1 |
| 18 | Percutaneous Vertebral Augmentation: The Status of Vertebroplasty and Current Controversies显示文摘 | Rikin Hargunani Thomas Le Corroller Khalid Khashoggi Kieran Murphy Peter Munk | 2011 | Semin Musculoskelet Radiol2011，，02： | 1 |
| 19 | Sustained release of vascular endothelial growth factor from mineralized poly (lactide-coglycolide) scaffolds for tissue engineering显示文摘 | MURPHY W L PETERS M C KOHN D H | 2000 | Biomaterial2000，21，24： | 1 |
| 20 | Association of Impaired Thrombolysis In Myocardial Infarction Myocardial Perfusion Grade With Ventricular Tachycardia and Ventricular Fibrillation Following Fibrinolytic Therapy for ST-Segment Elevation Myocardial Infarction显示文摘 | C. Michael Gibson Yuri B. Pride Jacqueline L. Buros Erin Lord Amy Shui Sabina A. Murphy Duane S. Pinto Peter J. Zimetbaum Marc S. Sabatine Christopher P. Cannon Mark E. Josephson | 2008 | Journal of the American College of Cardiology2008，，5： | 1 |
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