|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | New gene cassettes for trimethoprim resistance, dfrl3, and streptomycin-spectinomycin resistance, aadA4, inserted on a class 1 integron显示文摘 | Peter VA Christopher JT Keith PK | 2000 | Antimicrob A- gents Chemother2000，44，2： | 1 |
| 3 | Laparoscopic transgastric endoscopic retrograde cholangiopancreatography for benign common bile duct stricture after Roux-en-Y gastric bypass显示文摘 | Peters M Papasavas PK Caushaj PF | 2002 | Surg Endosc2002，16，7： | 1 |
| 4 | Drumstick(Moringa oleifera):A multipurpose Indian Vegetable显示文摘 | Ramachandran C Peter KV Gopalakrishnan PK | 1980 | Economic Botany1980，，34： | 1 |
| 5 | Bazedoxifene acetate:a selective estrogen receptor modulator with im- proved selectivity 显示文摘 | Baryy SK Yogendra PK Peter VNB | 2005 | Endocrinology2005，146，9： | 1 |
| 6 | Drumstick(Moringa oleifera):A multipurpose Indian vegetable显示文摘 | Ramachandran C Peter KV Gopalakrishnan PK | 1980 | EconomicBotany1980，34，3： | 1 |
| 7 | Progress in HDL-based therapies for atherosclerosis显示文摘 | Kuang-Yuh Chyu Peter A Shah PK | 2011 | Curr Atheroscler Rep2011，13，5： | 1 |
| 8 | Atropine resistant post infarction complete AV block: Possible role of adenosine and improvement with aminophylline 显示文摘 | Shah PK Nalos P Peter T | 1987 | Am Heart J1987，113，： | 1 |
| 9 | New gene cassettes for trimethoprim resistance,dfr13,and strepto mycin-spectin-omycin resistance,aad A4,inserted on aclass 1 integron显示文摘 | Peter VA Christopher JT Keith PK | 2000 | Antimicrob A gents Chemother2000，44，2： | 1 |
| 10 | Multiple metabolic defects during late pregnancy in women at high risk for type 2 diabetes 显示文摘 | Xiang AH Peters PK Trigo E | 1999 | Diabetes1999，48，4： | 1 |
| 11 | Phagocytosis and killing of Staphylococci by human polymorphonuclear and mononuclear leucocytes显示文摘 | Verbrugh HA Peters R Peterson PK and 1 other | | 0，，： | 1 |
| 12 | Micro-Scale method fortheophylline in body fluids by reversecphase, high-pressure liqid chromatography显示文摘 | Peter PK Sherwin AG | 1977 | Clinical Chemistry1977，23，3： | 1 |
| 13 | New gene cassettes for trimethoprim resistance, dfrlS, and streptomycin-spectinomycin resistance, aadA4, inserted on a class 1 integron显示文摘 | Peter VA Christopher JT Keith PK | 2000 | Antimicrob Agents Chemother2000，44，： | 1 |
| 14 | Prevention of pancreatic-β cell function and prevention of type 2 diabetes by pharmacological teeatment of insulin resistance in high-risk Hispanic women显示文摘 | Buchanan TA Xiang AH peters PK | 2002 | Diabetes2002，51，9： | 1 |
| 15 | Drumstick (Moringa oleifera): A multipurpose Indian vegetable显示文摘 | Ramachandran C Peter KV Gopalakrishnan PK | 1980 | Economic Botany1980，34，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员