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您的检索式：作者名="Peter Sima"
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| 1 | Bioactive substances with anti-neoplastic efficacy from marine invertebrates:Porifera and Coelenterata显示文摘An ever increasing demand for new lead compounds in the pharmaceutical industry has led scientists to search for natural bioactive products.Based on this extensive research,marine invertebrates now represent a rich source of novel substances with significant antineoplastic activities.As the current approach of synthesizing new and chemically modifying old drugs seems to have slowed down,and the identification of new anticancer drugs is not too promising,a new approach is clearly needed.The objective of this review is to present up-to-date data on these newer compounds.Based on the data summarized in this short review,it is clear that marine invertebrates represent an extremely important source of compounds with potential anti-cancer effects.Considering that we tested only a tiny number of Porifera and Coelenterata,the best is yet to come. | Peter Sima Vaclav Vetvicka | 2011 | World Journal of Clinical Oncology2011，2，11： | 1 |
| 2 | A salt wasting syndrome associated with cerebal disease显示文摘 | Peters JP Welt LG Sima EA et al | 1950 | Trans Assoc Am Physicians1950，63，： | 1 |
| 3 | Northwestward range expansion of the bumblebee Bombus haematurus into Central Europe is associated with warmer winters and niche conservatism显示文摘Species range expansions are crucial for understanding niche formation and the interaction with the environment.Here,we studied the bumblebee Bombus haematurus Kriechbaumer,1870,a species historically distributed from northern Serbia through northern Iran which has very recently started expanding northwestward into Central Europe without human-mediated dispersal(i.e.,it is a natural spread).After updating the global distribution of this species,we investigated if niche shifts took place during this range expansion between newly colonized and historical areas.In addition,we have explored which climatic factors may have favored the natural range expansion of the species.Our results indicated that Bombus haematurus has colonized large territories in 7 European countries outside the historical area in the period from the 1980s to 2018,a natural expansion over an area that equals 20%of the historical distribution.In addition,this bumblebee performs generalism in flower visitation and it occurs in different habitats,although a preference for forested areas clearly emerges.The land-use associated with the species in the colonized areas is similar to the historical distribution,indicating that no major niche shifts occurred during the spread.Furthermore,in recently colonized localities,the range expansion was associated with warming temperatures during the winter and also during both queen overwintering and emergence phases.These findings document a case of natural range expansion due to environmental change rather than due to niche shifts,and specifically they suggest that warmer winters could be linked to the process of natural colonization of new areas. | Paolo Biella Aleksandar Cetkovic Andrej Gogala Johann Neumayer Miklos Sarospataki Peter Sima Vladimir Smetana | 2021 | Insect Science2021，28，3： | 0 |
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