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| 1 | Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo显示文摘With the understanding of microRNA(miRNA or miR) functions in tumor initiation,progression,and metastasis,efforts are underway to develop new miRNA-based therapies.Very recently,we demonstrated effectiveness of a novel humanized bioengineered miR-124-3 p prodrug in controlling spontaneous lung metastasis in mouse models.This study was to investigate the molecular and cellular mechanisms by which miR-124-3 p controls tumor metastasis.Proteomics study identified a set of proteins selectively and significantly downregulated by bioengineered miR-124-3 p in A549 cells,which were assembled into multiple cellular components critical for metastatic potential.Among them,plectin(PLEC) was verified as a new direct target for miR-124-3 p that links cytoskeleton components and junctions.In miR-124-3 p-treated lung cancer and osteosarcoma cells,protein levels of vimentin,talin 1(TLN1),integrin beta-1(ITGB1),IQ motif containing GTPase activating protein 1(IQGAP1),cadherin2 or N-cadherin(CDH2),and junctional adhesion molecule A(F11 R or JAMA or JAM1) decreased,causing remodeling of cytoskeletons and disruption of cell-cell junctions.Furthermore,miR-124-3 p sharply suppressed the formation of focal adhesion plaques,leading to reduced cell adhesion capacity.Additionally,efficacy and safety of biologic miR-124-3 p therapy was established in an aggressive experimental metastasis mouse model in vivo.These results connect miR-124-3 p-PLEC signaling to other elements in the control of cytoskeleton,cell junctions,and adhesion essential for cancer cell invasion and extravasation towards metastasis,and support the promise of miR-124 therapy. | Linglong Deng Hannah Petrek Mei-Juan Tu Neelu Batra Ai-Xi Yu Ai-Ming Yu | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 2 |
| 2 | ACE gene I/D polymorphism and sarcoidosis pulmonary disease sererity显示文摘 | Mcgrath DS Foley PJ Petrek M | 2001 | Am J Respir Crit Care Med2001，164，： | 1 |
| 3 | Incidence of breast carcinoma-relatead Iympnedema 显示文摘 | Petrek JA Heelan MC | 1998 | Carncer1998，83，12： | 1 |
| 4 | Prognosis of pregnancy associated breast cancer显示文摘 | Petrek JA Dukoff R Rogatko A | 1991 | Cancer1991，67，4： | 1 |
| 5 | Post-treatment sarcoma in breast cancer patients显示文摘 | Brady MS Garfein CF Petrek JA | 1994 | Ann Surg Oncol1994，1，： | 1 |
| 6 | Pregnancy-associated breast cancer 显示文摘 | Petrek JA | 1991 | Semin Surg 0ncol1991，7，5： | 1 |
| 7 | Pregnancy safety after breast cancer 显示文摘 | Petrek JA | 1994 | Cancer1994，74，1： | 1 |
| 8 | Breast cancer and pregnancy显示文摘 | Cemignani ML Petrek JK Borgen PI | 1999 | Surg Clin North Arn1999，79，： | 1 |
| 9 | CC chemokine receptor gene polymorphisms in Czech patients with pulmonary sarcoidosis 显示文摘 | Petrek M Drabek J Kolek V | 2000 | Am I Respir Crit Care Med2000，162，31： | 1 |
| 10 | Pregnancy-associated breast cancer显示文摘 | Petrek JA Dukoff.Rogatko A | | 0，，： | 1 |
| 11 | Lymphedema in a cohort of breast cancinoma survivors 20 years after diagnosis显示文摘 | Senie RT Peters M | 1998 | Cancer1998，83，12： | 1 |
| 12 | Lymphedema: current issues in re- search and management 显示文摘 | Petrek JA Pressman PI Smith RA | 2000 | CA Cancer J Clin2000，50，5： | 1 |
| 13 | Lymph edema in a cohort of breast cancinoma survivors 20 years after diagnosis 显示文摘 | PETREK J A SEMIE R T PETERS M | 1998 | Cancer1998，83，12： | 1 |
| 14 | Breast cancer in pregnant and postpartum women显示文摘 | Seltzer V | 2003 | Jobstet Gyrmeeol Can2003，25，11： | 1 |
| 15 | Clara cell protein ( CC16 ) in serum and bronchoalveolar lavage fluid of subjects exposed to asbestos显示文摘 | PETREK M HERMANS C KOLEK V | 2002 | Biomarkers2002，7，1： | 1 |
| 16 | Incidence,time course,and determinants of menstrual bleeding after breast cancer treatment:a prospective study显示文摘 | Petrek JA Naughton MJ Case LD | 2006 | J Clin On- col2006，24，7： | 1 |
| 17 | Lymph edema in a cohort of breast cancinoma survivors 20 years after diagnosis 显示文摘 | Petrek JA Semie RT Peters M | 1998 | Cancer1998，83，12： | 1 |
| 18 | Prognosis of pregnancy-associated breast cancer显示文摘 | Petrek J A Dukoff R Rogatko A | 1991 | Cancer1991，67，4： | 1 |
| 19 | Pregnancy-associated breast cancer显示文摘 | Petrek JA Dukoff Rogatko A | 1991 | Cancer1991，67，14： | 1 |
| 20 | Pregnancy - associated breast cancer 显示文摘 | Petrek JA | 1991 | Semin Surg Oncol1991，7，5： | 1 |
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